Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts Academic Article uri icon

Overview

MeSH Major

  • Avian Sarcoma Viruses
  • Cell Transformation, Neoplastic
  • DNA, Viral

abstract

  • A relatively simple but stringent technique was developed to detect the integration of virus-specific DNA into the genomes of higher organisms. In both permissive (duck) and nonpermissive (mammalian) cells which normally contain no nucleotide sequences specific for Rous sarcoma virus, transformation by the virus results in the appearance of DNA specific for Rous sarcoma virus covalently integrated into strands of host-cell DNA containing reiterated sequences. Early after infection of mouse or duck cells by Rous sarcoma virus, unintegrated DNA specific for the virus can be demonstrated.

publication date

  • December 1973

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC427171

PubMed ID

  • 4361674

Additional Document Info

start page

  • 3067

end page

  • 71

volume

  • 70

number

  • 11