Identification and characterization of macrophage inflammatory protein 2 Academic Article uri icon

Overview

MeSH Major

  • Chemotactic Factors
  • Chemotaxis, Leukocyte
  • Macrophages

abstract

  • In response to endotoxin, macrophages secrete a protein with a molecular mass of approximately 6000 Da and with an affinity for heparin. This protein, which we term "macrophage inflammatory protein 2," is a potent chemotactic agent for human polymorphonuclear leukocytes. In addition, subcutaneous administration of the monokine causes a localized inflammatory reaction. Partial N-terminal sequence data reveal similarity to a family of proteins, the archetype of which is platelet factor 4. Although macrophage inflammatory protein 2 is a distinct member of the platelet factor 4 family, its sequence is most closely related to that of the gro/KC gene product, which is expressed in transformed or platelet-derived growth factor-treated cells.

publication date

  • January 1989

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC286522

PubMed ID

  • 2643119

Additional Document Info

start page

  • 612

end page

  • 6

volume

  • 86

number

  • 2