MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE Academic Article uri icon

Overview

MeSH Major

  • Central Nervous System
  • Central Nervous System Diseases
  • Histocytochemistry
  • Lipidoses
  • Mutation
  • Myelin Sheath
  • Neurochemistry
  • Peripheral Nerves
  • Research

abstract

  • Two mutant mice with deficient myelination are described. Quaking is a new autosomal recessive mutant mouse with marked tremor of the hindquarters. The mice eat, swim, breed, and nurse well even though the entire central nervous system is very deficient in myelin by histological and chemical criteria. Myelin formation is impaired; no destruction is seen. Peripheral nerves are myelinated. Jimpy, a known sex-linked mutation, has similar but more severe symptoms and similar pathology, with the additional feature of sudanophilic (nonpolar) lipid distributed in some white-matter tracts. Both mutants offer new opportunities for study of the formation and functions of myelin.

publication date

  • December 1964

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 14169723

Additional Document Info

start page

  • 309

end page

  • 11

volume

  • 144