QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model.
Breast Cancer Research.
Times cited: 35
- Lipid/polymer nanoparticles as tools to improve the therapeutic activity of existing and emerging anticancer drug combinations. Proceedings - 2004 International Conference on MEMS, NANO and Smart Systems, ICMENS 2004. 2004 Conference Paper