Selected publications
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Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.
Cell Stem Cell.
2017
Academic Article
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Times cited: 11 -
Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.
Nature Medicine.
2015
Academic Article
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Times cited: 46 -
Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias.
Blood.
2015
Academic Article
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Times cited: 14 -
CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.
Cancer Cell.
2015
Academic Article
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Times cited: 62 -
Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms.
Blood.
2014
Academic Article
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Times cited: 61 -
Sensitivity and resistance of JAK2 inhibitors to myeloproliferative neoplasms.
International Journal of Hematology.
2013
Review
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Times cited: 21 -
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.
Nature.
2012
Academic Article
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Times cited: 200 -
STATe-of-the-art approach: Using oligonucleotide decoys to target the "undruggable".
Cancer Discovery.
2012
Article
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Times cited: 2 -
Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent.
Cancer Discovery.
2012
Academic Article
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Times cited: 73 -
JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation.
Cancer Cell.
2011
Academic Article
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Times cited: 143 -
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.
Journal of Clinical Investigation.
2010
Academic Article
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Times cited: 121 -
Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis.
Blood.
2010
Academic Article
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Times cited: 56 -
JAK2 and MPL mutations in myeloproliferative neoplasms.
Acta Haematologica.
2008
Review
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Times cited: 7