Thompson, Craig B.

Selected publications

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations. Nature. 2018 Academic Article GET IT
Times cited: 39
Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity. Nature Cell Biology. 2018 Academic Article GET IT
Times cited: 8
JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition. Journal of Clinical Investigation. 2018 Academic Article GET IT
Times cited: 15
Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence. Nature Genetics. 2017 Academic Article GET IT
Times cited: 31
Combination targeted therapy to disrupt aberrant oncogenic signaling and reverse epigenetic dysfunction in IDH2- and TET2-mutant acute myeloid leukemia. Cancer Discovery. 2017 Academic Article GET IT
Times cited: 43
L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH. Nature Chemical Biology. 2017 Academic Article GET IT
Times cited: 54
Epigenetic identity in AML depends on disruption of nonpromoter regulatory elements and is affected by antagonistic effects of mutations in epigenetic modifiers. Cancer Discovery. 2017 Academic Article GET IT
Times cited: 28
In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors. Cell Metabolism. 2017 Academic Article GET IT
Times cited: 18
Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas. Science Translational Medicine. 2016 Academic Article GET IT
Times cited: 42
Cancer: Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016 Academic Article GET IT
Times cited: 100
Hypoxia Induces Production of L-2-Hydroxyglutarate. Cell Metabolism. 2015 Academic Article GET IT
Times cited: 146
Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients. Nature Communications. 2015 Academic Article GET IT
Times cited: 173
Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo. Science Translational Medicine. 2015 Academic Article GET IT
Times cited: 116
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Molecular Cell. 2014 Academic Article GET IT
Times cited: 131
At the Bench: Preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy. Journal of Leukocyte Biology. 2013 Review GET IT
Times cited: 160
The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization. Journal of Biological Chemistry. 2013 Academic Article GET IT
Times cited: 81
The proteasome activator PA200 regulates tumor cell responsiveness to glutamine and resistance to ionizing radiation. Molecular Cancer Research. 2012 Academic Article GET IT
Times cited: 12
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature. 2012 Academic Article GET IT
Times cited: 1000
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate. Cancer Cell. 2010 Academic Article GET IT
Times cited: 1107
The Proapoptotic Factors Bax and Bak Regulate T Cell Proliferation through Control of Endoplasmic Reticulum Ca²⁺ Homeostasis. Immunity. 2007 Academic Article GET IT
Times cited: 76
Akt stimulates aerobic glycolysis in cancer cells. Cancer Research. 2004 Academic Article GET IT
Times cited: 917
Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection. Virology. 2003 Academic Article GET IT
Times cited: 85
Bcl-xL complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. Journal of Biological Chemistry. 2002 Academic Article GET IT
Times cited: 51
Transcriptional activation of short interspersed elements by DNA-damaging agents. Genes Chromosomes and Cancer. 2001 Academic Article GET IT
Times cited: 86
Early release of mitochondrial cytochrome c and expression of mitochondrial epitope 7A6 with a porphyrin-derived photosensitizer: Bcl-2 and Bcl-X(L) overexpression do not prevent early mitochondrial events but still depress caspase activity. Laboratory Investigation. 1999 Academic Article GET IT
Times cited: 71
Bcl-x(L) and Bcl-2 expression in squamous cell carcinoma of the head and neck. Cancer. 1999 Academic Article GET IT
Times cited: 96
Signal transduction pathways that regulate cell survival and cell death. Oncogene. 1998 Review GET IT
Times cited: 168
A Bcl-x(L) transgene promotes malignant conversion of chemically initiated skin papillomas. Cancer Research. 1998 Academic Article GET IT
Times cited: 60
Apoptosis and disease: Regulation and clinical relevance of programmed cell death. Annual Review of Medicine. 1997 Review GET IT
Times cited: 302
Apoptotic signaling in lymphocytes. Current opinion in hematology. 1996 Review GET IT
Times cited: 9
Bax-independent inhibition of apoptosis by Bcl-XL. Nature. 1996 Academic Article GET IT
Times cited: 433
Expression of Bcl-xL Can Confer a Multidrug Resistance Phenotype. Blood. 1995 Academic Article GET IT
Times cited: 355

VIVO Weill Cornell Medical College

Thompson, Craig B. External Author

Publications

Selected publications