Selected publications
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Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.
Nature.
2018
Academic Article
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Times cited: 39 -
Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.
Nature Cell Biology.
2018
Academic Article
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Times cited: 8 -
JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.
Journal of Clinical Investigation.
2018
Academic Article
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Times cited: 15 -
Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence.
Nature Genetics.
2017
Academic Article
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Times cited: 31 -
Combination targeted therapy to disrupt aberrant oncogenic signaling and reverse epigenetic dysfunction in IDH2- and TET2-mutant acute myeloid leukemia.
Cancer Discovery.
2017
Academic Article
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Times cited: 43 -
L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH.
Nature Chemical Biology.
2017
Academic Article
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Times cited: 54 -
Epigenetic identity in AML depends on disruption of nonpromoter regulatory elements and is affected by antagonistic effects of mutations in epigenetic modifiers.
Cancer Discovery.
2017
Academic Article
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Times cited: 28 -
In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors.
Cell Metabolism.
2017
Academic Article
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Times cited: 18 -
Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas.
Science Translational Medicine.
2016
Academic Article
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Times cited: 42 -
Cancer: Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.
Science.
2016
Academic Article
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Times cited: 100 -
Hypoxia Induces Production of L-2-Hydroxyglutarate.
Cell Metabolism.
2015
Academic Article
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Times cited: 146 -
Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients.
Nature Communications.
2015
Academic Article
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Times cited: 173 -
Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo.
Science Translational Medicine.
2015
Academic Article
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Times cited: 116 -
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.
Molecular Cell.
2014
Academic Article
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Times cited: 131 -
At the Bench: Preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy.
Journal of Leukocyte Biology.
2013
Review
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Times cited: 160 -
The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.
Journal of Biological Chemistry.
2013
Academic Article
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Times cited: 81 -
The proteasome activator PA200 regulates tumor cell responsiveness to glutamine and resistance to ionizing radiation.
Molecular Cancer Research.
2012
Academic Article
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Times cited: 12 -
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.
Nature.
2012
Academic Article
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Times cited: 1000 -
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate.
Cancer Cell.
2010
Academic Article
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Times cited: 1107 -
The Proapoptotic Factors Bax and Bak Regulate T Cell Proliferation through Control of Endoplasmic Reticulum Ca2+ Homeostasis.
Immunity.
2007
Academic Article
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Times cited: 76 -
Akt stimulates aerobic glycolysis in cancer cells.
Cancer Research.
2004
Academic Article
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Times cited: 917 -
Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection.
Virology.
2003
Academic Article
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Times cited: 85 -
Bcl-xL complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism.
Journal of Biological Chemistry.
2002
Academic Article
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Times cited: 51 -
Transcriptional activation of short interspersed elements by DNA-damaging agents.
Genes Chromosomes and Cancer.
2001
Academic Article
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Times cited: 86 -
Early release of mitochondrial cytochrome c and expression of mitochondrial epitope 7A6 with a porphyrin-derived photosensitizer: Bcl-2 and Bcl-X(L) overexpression do not prevent early mitochondrial events but still depress caspase activity.
Laboratory Investigation.
1999
Academic Article
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Times cited: 71 -
Bcl-x(L) and Bcl-2 expression in squamous cell carcinoma of the head and neck.
Cancer.
1999
Academic Article
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Times cited: 96 -
Signal transduction pathways that regulate cell survival and cell death.
Oncogene.
1998
Review
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Times cited: 168 -
A Bcl-x(L) transgene promotes malignant conversion of chemically initiated skin papillomas.
Cancer Research.
1998
Academic Article
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Times cited: 60 -
Apoptosis and disease: Regulation and clinical relevance of programmed cell death.
Annual Review of Medicine.
1997
Review
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Times cited: 302 -
Apoptotic signaling in lymphocytes.
Current opinion in hematology.
1996
Review
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Times cited: 9 -
Bax-independent inhibition of apoptosis by Bcl-XL.
Nature.
1996
Academic Article
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Times cited: 433 -
Expression of Bcl-xL Can Confer a Multidrug Resistance Phenotype.
Blood.
1995
Academic Article
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Times cited: 355