Selected publications
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Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis.
Nature Communications.
2016
Academic Article
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Times cited: 232 -
Phase II trial of sorafenib in patients with chemotherapy refractory metastatic esophageal and gastroesophageal (GE) junction cancer.
PLoS ONE.
2015
Academic Article
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Times cited: 20 -
Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.
Cancer Cell.
2015
Academic Article
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Times cited: 106 -
NF2 loss promotes oncogenic RAS-induced thyroid cancers via YAP-dependent transactivation of RAS proteins and sensitizes them to MEK inhibition.
Cancer Discovery.
2015
Academic Article
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Times cited: 52 -
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
Nature Cell Biology.
2015
Academic Article
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Times cited: 57 -
The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation.
Blood.
2014
Academic Article
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Times cited: 296 -
Remodeling of the methylation landscape in breast cancer metastasis.
PLoS ONE.
2014
Academic Article
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Times cited: 13 -
Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy.
Clinical Cancer Research.
2014
Academic Article
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Times cited: 129 -
Frequent disruption of the RB pathway in indolent follicular lymphoma suggests a new combination therapy.
Journal of Experimental Medicine.
2014
Academic Article
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Times cited: 19 -
Genome-wide analysis of the role of copy-number variation in pancreatic cancer risk.
Frontiers in Genetics.
2014
Academic Article
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Times cited: 6 -
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.
Nature Genetics.
2014
Academic Article
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Times cited: 188 -
Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.
Nature Genetics.
2014
Academic Article
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Times cited: 84 -
Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers.
Journal of Clinical Investigation.
2013
Academic Article
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Times cited: 101 -
A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia.
Nature Genetics.
2013
Academic Article
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Times cited: 147 -
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.
Nature Medicine.
2013
Academic Article
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Times cited: 113 -
Susceptibility Loci Associated with Specific and Shared Subtypes of Lymphoid Malignancies.
PLoS Genetics.
2013
Academic Article
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Times cited: 33 -
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.
Nature Genetics.
2012
Academic Article
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Times cited: 393 -
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
New England Journal of Medicine.
2012
Academic Article
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Times cited: 1087 -
EGFR-mutant lung adenocarcinomas treated first-line with the novel EGFR inhibitor, XL647, can subsequently retain moderate sensitivity to erlotinib.
Journal of Thoracic Oncology.
2012
Academic Article
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Times cited: 15 -
Stat3 mediates expression of autotaxin in breast cancer.
PLoS ONE.
2011
Academic Article
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Times cited: 39 -
Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling.
Science Translational Medicine.
2011
Academic Article
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Times cited: 347 -
Breast cancer methylomes establish an epigenomic foundation for metastasis.
Science Translational Medicine.
2011
Academic Article
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Times cited: 183 -
Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid.
Journal of Biological Chemistry.
2011
Academic Article
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Times cited: 67 -
Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells.
Nature Biotechnology.
2011
Academic Article
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Times cited: 213 -
Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans.
Journal of Clinical Investigation.
2010
Academic Article
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Times cited: 400 -
The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner.
Proceedings of the National Academy of Sciences of the United States of America.
2010
Academic Article
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Times cited: 336 -
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.
Nature Genetics.
2010
Academic Article
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Times cited: 403 -
Identification of DOK genes as lung tumor suppressors.
Nature Genetics.
2010
Academic Article
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Times cited: 78 -
Comprehensive genomic analysis reveals clinically relevant molecular distinctions between thymic carcinomas and thymomas.
Clinical Cancer Research.
2009
Academic Article
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Times cited: 111 -
Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.
Nature.
2009
Academic Article
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Times cited: 640 -
V600EBRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway.
Proceedings of the National Academy of Sciences of the United States of America.
2009
Academic Article
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Times cited: 347 -
BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage.
STEM CELLS.
2009
Academic Article
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Times cited: 66