Meyer Cancer Center Academic Department

Research

administers grant

• A multi-omics, single-cell toolkit to study disrupted hematopoietic differentiation in clonal hematopoiesis
• Advancing the therapeutic landscape for Chronic Myelomonocytic Leukemia (CMML)
• BPTF-mediated gene regulation in prostate cancer
• BWF 2015 Career Award for Medical Scientists
• Biology of R-Spondin-Induced Sensitization to Asparaginase in Colorectal Cancer
• Bridging predictive models and precision immunotherapies
• Center for Integrated Cellular Analysis
• Characterization of mpMRI Features Associated with Persistence and Recurrence of Prostate Cancer After Partial Gland Ablation
• Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis
• Charting the differentiation topology of SF3B1 mutated clonal hematopoiesis (CH) and myelodysplastic syndromes (MDS) via a multi-omics single-cell toolkit
• Clinical identification and targeting of non-neuroendocrine lineage plasticity in castration-resistant prostate cancer
• Collaborative genomic alterations and transcriptional control in prostate cancer
• Combing omics and imaging approaches to dissect critical regulatory proteins and enhancer hierarchies during pluripotent state transitions
• Computational Methods for Identifying Non-Coding Cancer Drivers
• Computational and experimental methods for scalable identification of oncogenic non-coding regions
• Coordinate Regulation of Oncogenic Signaling Pathways in SPOP Mutant Prostate Cancer
• DNA Vaccines Against Cancer and Infectious Organisms
• Deciphering differentiation hierarchies, heritability and plasticity in gliomas via single-cell multi-omics.
• Deciphering heritability, plasticity and differentiation trajectories in gliomas via single-cell multi-omics
• Deciphering the fitness determinants of clonal mosaicism
• Deciphering the pathobiological mechanisms of dietary fat sensing in breast cancer
• Defining Epidrivers of CLL Evolution in Response to Targeted Therapy
• Defining Evolutionary Trajectories Driving Prostate Cancer Metastases
• Defining the impact of Kras mutational heterogeneity on the tumor microenvironment in pancreatic cancer
• Defining the role of DNA methylation modifier mutations in reshaping blood differentiation topology
• Determining Metastatic Drivers of Pten/p53-Loss-Driven Prostate Cancer Using Evolving DNA Barcodes
• Determining and Targeting Evolutionary Trajectories Driving Bladder Cancer
• Developing Novel Therapeutic Approaches for Classical and Variant Hairy Cell Leukemia (Core 2)
• Developing Novel Therapeutic Approaches for Classical and Variant Hairy Cell Leukemia (Project 1)
• Differential role of different NAD+ kinase Isoforms in melanoma metastasis
• Discovery of diabetes-relevant β cell enhancers through 4D enhancer mapping, integrative analysis, and large-scale CRISPRi perturbation screens
• Dissecting the role of folate deficiency in lung cancer development and genomic instability
• Enhancing Breast Cancer Therapy by Inhibiting the Adenosine Receptor and Oxygen Consumption
• Enterome Services Agreement
• Epigenetic mechanisms of transcriptional activation of a novel oncogenic ALK variant in cancer
• Evaluation of Transperineal Biopsy under Local Anesthesia, a Novel approach to Decrease Post-Biopsy Infections and Improve Cancer Detection
• Expanding the GoT toolkit to link single-cell clonal genotypes with protein, transcriptomic, epigenomic and spatial phenotypes
• Experimental And Preclinical Modeling Of NUP98-Rearranged Acute Leukemia
• Folate deficiency as a source of genotoxic formaldehyde in cancer
• Functional Dissection of Regulatory Myeloid Cells in Microbe-Immune Crosstalk in Skin
• Gene regulatory networks in early lung epithelial cell fate decisions
• Genome-wide mutational integration for ultra-sensitive plasma tumor burden monitoring in immunotherapy
• Group 2 Innate Lymphoid Cell Regulation of Pancreatic Cancer Immunity
• High-parametric flow cytometry cell sorter for human immunology studies.
• Identifying acquired vulnerabilities driven by lineage plasticity and drug resistance in CRC
• Identifying and targeting 3D regulatory nodes that maintain glioblastoma programs.
• Image-guided Trp-IDO/TDO-Kyn-AHR pathway inhibition, combined with immunotherapy
• Imaging tumor and T cell responses to metabolic and immune modulation
• In Vivo Base Editing for Precision Oncology Models
• Interrogating unique DC adaptations to tissue to promote barrier immunity and tolerance
• Interrogation of the chromatin landscape to drive maturation of hPSC-derived skeletal muscle.
• Investigating novel KRAS inhibitors effects on the tumor-immune responses and integration of KRAS inhibition with immune based therapies.
• Investigating the role of propionate metabolism in cell senescence and aging
• Ludwig Collaborative Laboratory
• Lymphoma Scientific Research Mentoring Program (LSRMP)
• MSK Immuno-Oncology for the Translational Researcher Short Course
• Mark Foundation Emerging Leader Award
• Mechanism-Based Approach for Combination Therapies with Immune Modulation for Management of Patients with Urothelial Cancers of the Upper Urinary Tract
• Mitogenic and Oncogenic Regulation of ERK/RSK Signaling
• Mitogenic and Oncogenic Regulation of ERK/RSK Signaling
• Mitogenic and Oncogenic Regulation of ERK/RSK Signaling
• Mosaic: post-zygotic mutations in vascular and lymphatic developmental disorders.
• Mutations in epigenetic modifiers lead to alternative splicing in clonal hematopoiesis
• New mechanisms governing skin tissue residency memory T cells
• Nonclinical Research Agreement - BMS
• Novel Mouse Models for Quantitative Understanding of Baseline and Therapy-Driven Evolution of Prostate Cancer Metastasis
• Novel cell therapy approaches for molecularly defined subsets of therapy-resistant melanoma
• Optimizing Dual-Targeted and Dual-Armored CAR T Cells for Small Cell Lung Cancer
• Organizational principles and functional role of 3D enhancer hubs in cell fate decisions
• Pelvic fascia spARing radical prostatectomy TrIAL (PARTIAL)
• Precision, plasma-only, melanoma ctDNA residual disease monitoring
• Propionate metabolism and cancer
• Prostate Cancer Comparative Outcomes of New Conceptual Paradigms for Treatment (PC CONCEPT)
• Proteogenomic studies to understand mechanisms and drivers of resistance to immunotherapies
• Randomized Trial Comparing Transperineal vs. Transrectal MRI-targeted Prostate Biopsy
• Research Scholar Grants
• Revolution Medicines, Inc. Biopharma
• Signal Transduction to P70 S6 Kinase 1
• Single-cell multi-omics to link clonal mosaicism (CM) genotypes with chromatin, epigenomic, transcriptomic and protein phenotypes
• Sponsored Research Agreement - Merghoub Lab
• Structure, Function, and Dynamics of Macro-molecular Complexes that Execute and Regulate Genome Function
• Studies of the initiation and progression of small cell lung cancer using cells derived by differentiation from human pluripotent stem cells
• Studying the role of macrophages and gluconeogenesis in the regulation of Mycobacterium tuberculosis persistence in a mouse model of latency
• Targeting BRCA1-mutant breast cancer cells with folate and vitamin C
• Targeting BRCA1/2-deficient cancers with folate and vitamin C
• Targeting immune evasion in gastroesophageal cancer
• The role and regulation of the selenocysteine proteome in melanoma metastasis
• The role of NAGK cysteine deprotonation in nutrient stress and cancer progression
• Tumor selective inhibition of the WNT pathway
• Turning insulin addiction and KRAS/BRCA2 co-mutations into vulnerabilities for pancreatic cancer treatment
• Uncovering Novel Regulators of HSC Fate Control
• Understanding tumor-immune interactions in cancer initiation and progression (Long-Term Fellowship 2022)
• tRNA wobble modifications as drivers of the adaptive proteome in stress resistance and metastasis