Molecular and cellular biology

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RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons.. 41. 2021
Structure of Fission Yeast Transcription Factor Pho7 Bound to pho1 Promoter DNA and Effect of Pho7 Mutations on DNA Binding and Phosphate Homeostasis.. 39. 2019
The Histone Variant MacroH2A Blocks Cellular Reprogramming by Inhibiting Mesenchymal-to-Epithelial Transition.. 38. 2018
mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response.. 38. 2018
Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity.. 37. 2017
A GIPC1-Palmitate Switch Modulates Dopamine Drd3 Receptor Trafficking and Signaling.. 36. 2016
Reduced Histone Expression or a Defect in Chromatin Assembly Induces Respiration.. 36. 2016
The Overlooked Fact: Fundamental Need for Spike-In Control for Virtually All Genome-Wide Analyses.. 36. 2015
Genome-Wide Organization of GATA1 and TAL1 Determined at High Resolution.. 36. 2015
IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis.. 35. 2015
Modulation of Macrophage Gene Expression via Liver X Receptor α Serine 198 Phosphorylation.. 35. 2015
Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation.. 35. 2015
NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.. 35. 2014
Loss of BRMS1 promotes a mesenchymal phenotype through NF-κB-dependent regulation of Twist1.. 35. 2014
A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity.. 34. 2014
Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization.. 34. 2014
Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice.. 34. 2014
Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.. 34. 2014
A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster.. 34. 2013
S6K1 negatively regulates TAK1 activity in the toll-like receptor signaling pathway.. 34. 2013
Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation.. 33. 2013
ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes.. 33. 2013
The C terminus of the histone chaperone Asf1 cross-links to histone H3 in yeast and promotes interaction with histones H3 and H4.. 33. 2012
FoxO-dependent regulation of diacylglycerol kinase α gene expression.. 32. 2012
The linker histone plays a dual role during gametogenesis in Saccharomyces cerevisiae.. 32. 2012
Growth inhibition by miR-519 via multiple p21-inducing pathways.. 32. 2012
PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation.. 32. 2012
Glucocorticoid-dependent phosphorylation of the transcriptional coregulator GRIP1.. 32. 2011
Analyses of Candida Cdc13 orthologues revealed a novel OB fold dimer arrangement, dimerization-assisted DNA binding, and substantial structural differences between Cdc13 and RPA70.. 32. 2011
Genome-wide transcriptional dependence on conserved regions of Mot1.. 31. 2011
Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption.. 31. 2011
Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes.. 31. 2011
A steering model of endothelial sheet migration recapitulates monolayer integrity and directed collective migration.. 31. 2010
Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation.. 31. 2010
Sequential recruitment of SAGA and TFIID in a genomic response to DNA damage in Saccharomyces cerevisiae.. 31. 2010
Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3.. 30. 2010
Inhibition of human peptide deformylase disrupts mitochondrial function.. 30. 2010
The type I interferon signaling pathway is a target for glucocorticoid inhibition.. 30. 2010
Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation.. 30. 2010
Separable functions of the fission yeast Spt5 carboxyl-terminal domain (CTD) in capping enzyme binding and transcription elongation overlap with those of the RNA polymerase II CTD.. 30. 2010
Rap1 in Candida albicans: an unusual structural organization and a critical function in suppressing telomere recombination.. 30. 2009
Regulation of protein synthesis by ionizing radiation.. 29. 2009
The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells.. 29. 2009
ADAM9 is involved in pathological retinal neovascularization.. 29. 2009
Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer.. 29. 2008
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth.. 29. 2008
Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2.. 29. 2008
Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo.. 29. 2008
NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila.. 28. 2008
Phosphorylation of liver X receptor alpha selectively regulates target gene expression in macrophages.. 28. 2008
CtBP is an essential corepressor for BCL6 autoregulation.. 28. 2008
A mouse gene that coordinates epigenetic controls and transcriptional interference to achieve tissue-specific expression.. 28. 2007
G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells.. 27. 2007
Chromatin disassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators.. 27. 2007
Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex.. 27. 2007
NuA4-directed chromatin transactions throughout the Saccharomyces cerevisiae genome.. 27. 2007
Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6.. 27. 2007
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation.. 27. 2007
Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repair.. 27. 2007
An origin of DNA replication in the promoter region of the human fragile X mental retardation (FMR1) gene.. 27. 2006
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.. 26. 2006
Persistence of cooperatively stabilized signaling clusters drives T-cell activation.. 26. 2006
The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1.. 26. 2006
Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis.. 26. 2006
Identification of new human origins of DNA replication by an origin-trapping assay.. 26. 2006
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.. 26. 2006
The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation.. 26. 2006
Regulation of late G1/S phase transition and APC Cdh1 by reactive oxygen species.. 26. 2006
Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells.. 26. 2006
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.. 26. 2006
Genome-wide relationships between TAF1 and histone acetyltransferases in Saccharomyces cerevisiae.. 26. 2006
PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells.. 26. 2006
Suppression of intestinal neoplasia by deletion of Dnmt3b.. 26. 2006
Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells.. 26. 2006
Kaiso-deficient mice show resistance to intestinal cancer.. 26. 2006
Rec2 interplay with both Brh2 and Rad51 balances recombinational repair in Ustilago maydis.. 26. 2006
Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation.. 25. 2005
Structure-function analysis of the human TFIIB-related factor II protein reveals an essential role for the C-terminal domain in RNA polymerase III transcription.. 25. 2005
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth.. 25. 2005
DNA-binding and transactivation activities are essential for TAp63 protein degradation.. 25. 2005
FLIP protects against hypoxia/reoxygenation-induced endothelial cell apoptosis by inhibiting Bax activation.. 25. 2005
Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells.. 25. 2005
Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair.. 25. 2005
Brh2-Dss1 interplay enables properly controlled recombination in Ustilago maydis.. 25. 2005
The phosphoinositide phosphatase Sjl2 is recruited to cortical actin patches in the control of vesicle formation and fission during endocytosis.. 25. 2005
Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.. 25. 2005
The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma.. 25. 2005
The histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase.. 25. 2005
Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1.. 24. 2004
Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis.. 24. 2004
Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression.. 24. 2004
PRAM-1 is required for optimal integrin-dependent neutrophil function.. 24. 2004
Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae.. 24. 2004
Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy.. 24. 2004
Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.. 24. 2004
The adapter molecule Sin regulates T-cell-receptor-mediated signal transduction by modulating signaling substrate availability.. 24. 2004
Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site.. 24. 2004
Casein kinase Iepsilon modulates the signaling specificities of dishevelled.. 24. 2004
A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.. 24. 2004
Essential role for ADAM19 in cardiovascular morphogenesis.. 24. 2004
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E.. 24. 2004
A conserved telomerase motif within the catalytic domain of telomerase reverse transcriptase is specifically required for repeat addition processivity.. 23. 2003
Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis.. 23. 2003
Requirement for a nuclear function of beta-catenin in Wnt signaling.. 23. 2003
Retinoic acid receptor-mediated induction of ABCA1 in macrophages.. 23. 2003
Potential role for ADAM15 in pathological neovascularization in mice.. 23. 2003
Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.. 23. 2003
The RNA binding domain of Jerky consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs.. 23. 2003
Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.. 23. 2003
Structural and functional analysis of mutations along the crystallographic dimer interface of the yeast TATA binding protein.. 23. 2003
In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.. 22. 2002
The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway.. 22. 2002
NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer.. 22. 2002
A maternal Smad protein regulates early embryonic apoptosis in Xenopus laevis.. 22. 2002
Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.. 22. 2002
Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life.. 22. 2002
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling.. 22. 2002
Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction.. 22. 2002
Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia.. 22. 2002
Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway.. 21. 2001
Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1.. 21. 2001
Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors.. 21. 2001
Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo.. 21. 2001
MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling.. 21. 2001
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.. 20. 2000
Characterization of the interaction between the nuclease and reverse transcriptase activity of the yeast telomerase complex.. 20. 2000
In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions.. 20. 2000
HES-1 repression of differentiation and proliferation in PC12 cells: role for the helix 3-helix 4 domain in transcription repression.. 20. 2000
TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor.. 20. 2000
Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase.. 20. 2000
The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein.. 20. 2000
The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.. 20. 2000
Tumor necrosis factor alpha inhibits type I collagen synthesis through repressive CCAAT/enhancer-binding proteins.. 20. 2000
LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.. 19. 1999
The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.. 19. 1999
Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids.. 19. 1999
Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer.. 19. 1999
Subtle mutagenesis by ends-in recombination in malaria parasites.. 19. 1999
p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex.. 19. 1999
Activation of IkappaB kinase beta by protein kinase C isoforms.. 19. 1999
A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation.. 19. 1999
rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases.. 19. 1999
Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair.. 18. 1998
14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity.. 18. 1998
Genetic, physical, and functional interactions between the triphosphatase and guanylyltransferase components of the yeast mRNA capping apparatus.. 18. 1998
Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter.. 18. 1998
Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells.. 18. 1998
The promyelocytic leukemia zinc finger protein affects myeloid cell growth, differentiation, and apoptosis.. 18. 1998
Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homolog, function together in yeast vacuolar protein trafficking.. 18. 1998
Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.. 18. 1998
Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein.. 18. 1998
Ash1, a daughter cell-specific protein, is required for pseudohyphal growth of Saccharomyces cerevisiae.. 18. 1998
Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation.. 18. 1998
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.. 18. 1998
Stat3 activation is required for cellular transformation by v-src.. 18. 1998
Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site.. 18. 1998
pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167.. 18. 1998
Cloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1.. 18. 1998
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation.. 17. 1997
Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade.. 17. 1997
Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor.. 17. 1997
Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms.. 17. 1997
Sequence-mediated regulation of adenovirus gene expression by repression of mRNA accumulation.. 17. 1997
Functional nucleotide excision repair is required for the preferential removal of N-ethylpurines from the transcribed strand of the dihydrofolate reductase gene of Chinese hamster ovary cells.. 17. 1997
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase.. 17. 1997
Differential regulation of neurogenesis by the two Xenopus GATA-1 genes.. 17. 1997
Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases.. 17. 1997
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.. 16. 1996
The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein.. 16. 1996
NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.. 16. 1996
Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae.. 16. 1996
Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).. 16. 1996
YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites.. 16. 1996
Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.. 16. 1996
Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation.. 16. 1996
Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase.. 16. 1996
Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cells.. 16. 1996
A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins.. 16. 1996
Replication initiates at multiple dispersed sites in the ribosomal DNA plasmid of the protozoan parasite Entamoeba histolytica.. 16. 1996
The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis.. 16. 1996
The Oct-1 POU-specific domain can stimulate small nuclear RNA gene transcription by stabilizing the basal transcription complex SNAPc.. 16. 1996
Evidence for two catalytically active kinase domains in pp90rsk.. 16. 1996
Mutational analysis of the Saccharomyces cerevisiae ABD1 gene: cap methyltransferase activity is essential for cell growth.. 16. 1996
Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo.. 16. 1996
CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation.. 15. 1995
A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development.. 15. 1995
Mutation avoidance and DNA repair proficiency in Ustilago maydis are differentially lost with progressive truncation of the REC1 gene product.. 15. 1995
A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells.. 15. 1995
Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene.. 15. 1995
Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway.. 15. 1995
Molecular characterization of a novel transcription factor that controls stromelysin expression.. 15. 1995
Homotypic interactions of chicken GATA-1 can mediate transcriptional activation.. 15. 1995
Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism.. 15. 1995
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.. 15. 1995
The BN51 protein is a polymerase (Pol)-specific subunit of RNA Pol III which reveals a link between Pol III transcription and pre-rRNA processing.. 15. 1995
The REC2 gene encodes the homologous pairing protein of Ustilago maydis.. 14. 1994
NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1.. 14. 1994
The GLC7 type 1 protein phosphatase is required for glucose repression in Saccharomyces cerevisiae.. 14. 1994
Structure of REC2, a recombinational repair gene of Ustilago maydis, and its function in homologous recombination between plasmid and chromosomal sequences.. 14. 1994
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.. 14. 1994
Sequence elements upstream of the 3' cleavage site confer substrate strength to the adenovirus L1 and L3 polyadenylation sites.. 14. 1994
Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways.. 14. 1994
A unique palindromic element mediates gamma interferon induction of mig gene expression.. 14. 1994
Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.. 14. 1994
NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype.. 14. 1994
p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation.. 14. 1994
Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides.. 13. 1993
Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.. 13. 1993
Inactivation of c-Yes tyrosine kinase by elevation of intracellular calcium levels.. 13. 1993
A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.. 13. 1993
A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.. 13. 1993
3' RNA processing efficiency plays a primary role in generating termination-competent RNA polymerase II elongation complexes.. 13. 1993
An octamer motif contributes to the expression of the retinoic acid-regulated zinc finger gene Rex-1 (Zfp-42) in F9 teratocarcinoma cells.. 13. 1993
Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells.. 13. 1993
hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.. 13. 1993
Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes.. 13. 1993
Characterization of the mouse beta maj globin transcription termination region: a spacing sequence is required between the poly(A) signal sequence and multiple downstream termination elements.. 13. 1993
Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction.. 12. 1992
Distinct roles for the two cGATA-1 finger domains.. 12. 1992
Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes.. 12. 1992
Expression of a yeast metallothionein gene family is activated by a single metalloregulatory transcription factor.. 12. 1992
A dominant negative mutation in a spliceosomal ATPase affects ATP hydrolysis but not binding to the spliceosome.. 12. 1992
Down-regulation of cystic fibrosis transmembrane conductance regulator gene expression by agents that modulate intracellular divalent cations.. 12. 1992
Induction of HSP70 gene expression by the antiproliferative prostaglandin PGA2: a growth-dependent response mediated by activation of heat shock transcription factor.. 12. 1992
Nuclear localization and regulation of erk- and rsk-encoded protein kinases.. 12. 1992
Interaction of Wnt-1 proteins with the binding protein BiP.. 12. 1992
Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals.. 12. 1992
The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.. 12. 1992
Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice.. 12. 1992
Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.. 12. 1992
A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation.. 11. 1991
Sequences regulating temporal poly(A) site switching in the adenovirus major late transcription unit.. 11. 1991
Interleukin-2-triggered Raf-1 expression, phosphorylation, and associated kinase activity increase through G1 and S in CD3-stimulated primary human T cells.. 11. 1991
Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro.. 11. 1991
Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction.. 11. 1991
trans-Activation of a globin promoter in nonerythroid cells.. 11. 1991
Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.. 10. 1990
Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis.. 10. 1990
Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation.. 10. 1990
A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain.. 10. 1990
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.. 10. 1990
mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element.. 10. 1990
Association of catalytic and regulatory subunits of cyclic AMP-dependent protein kinase requires a negatively charged side group at a conserved threonine.. 10. 1990
The src protein contains multiple domains for specific attachment to membranes.. 10. 1990
Structure and variability of human chromosome ends.. 10. 1990
Cyclic AMP analogs and retinoic acid influence the expression of retinoic acid receptor alpha, beta, and gamma mRNAs in F9 teratocarcinoma cells.. 10. 1990
Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele.. 10. 1990
Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells.. 9. 1989
Cloning and disruption of Ustilago maydis genes.. 9. 1989
Selective expression of alternative lck mRNAs in human malignant cell lines.. 9. 1989
Sequence and structural requirements of a mitochondrial protein import signal defined by saturation cassette mutagenesis.. 9. 1989
Construction and properties of replication-competent murine retroviral vectors encoding methotrexate resistance.. 9. 1989
Nerve growth factor regulates gene expression by several distinct mechanisms.. 9. 1989
Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein.. 8. 1988
Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.. 8. 1988
Characterization of a component of the yeast secretion machinery: identification of the SEC18 gene product.. 8. 1988
Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox.. 8. 1988
Isolation and characterization of an autonomously replicating sequence from Ustilago maydis.. 8. 1988
Polyomavirus middle T antigen induces ribosomal protein S6 phosphorylation through pp60c-src-dependent and -independent pathways.. 8. 1988
The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant.. 8. 1988
Intracellular sorting and processing of a yeast vacuolar hydrolase: proteinase A propeptide contains vacuolar targeting information.. 8. 1988
Identification of protein products encoded by the proto-oncogene int-1.. 7. 1987
The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway.. 7. 1987
The yeast F1-ATPase beta subunit precursor contains functionally redundant mitochondrial protein import information.. 7. 1987
Interaction of GAL4 and GAL80 gene regulatory proteins in vitro.. 7. 1987
Antibodies to Xenopus egg S6 kinase II recognize S6 kinase from progesterone- and insulin-stimulated Xenopus oocytes and from proliferating chicken embryo fibroblasts.. 7. 1987
Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.. 7. 1987
Definition of regions in human c-myc that are involved in transformation and nuclear localization.. 7. 1987
Features of the chicken c-myc gene that influence the structure of c-myc RNA in normal cells and bursal lymphomas.. 6. 1986
Rearrangement at the 5' end of amplified c-myc in human COLO 320 cells is associated with abnormal transcription.. 6. 1986
Cell-type-specific synthesis of murine immunoglobulin mu RNA from an adenovirus vector.. 6. 1986
Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene.. 5. 1985
Constitutively expressed rat mRNA encoding a 70-kilodalton heat-shock-like protein.. 5. 1985
Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene.. 5. 1985
Clonal variants of PC12 pheochromocytoma cells with defects in cAMP-dependent protein kinases induce ornithine decarboxylase in response to nerve growth factor but not to adenosine agonists.. 5. 1985
Isolation of duplicated human c-src genes located on chromosomes 1 and 20.. 5. 1985
Invertase beta-galactosidase hybrid proteins fail to be transported from the endoplasmic reticulum in Saccharomyces cerevisiae.. 4. 1984
Isolation of cDNA clones for genes exhibiting reduced expression after differentiation of murine teratocarcinoma stem cells.. 4. 1984
Premature termination by human RNA polymerase II occurs temporally in the adenovirus major late transcriptional unit.. 4. 1984
Integration and expression of several molecular forms of Rous sarcoma virus DNA used for transfection of mouse cells.. 4. 1984
Size-variant pp60src proteins of recovered avian sarcoma viruses interact with adhesion plaques as peripheral membrane proteins: effects on cell transformation.. 4. 1984
A DNA-binding protein from Ustilago maydis prefers duplex DNA without chain interruptions.. 3. 1983
Lectin-resistant mutants of polarized epithelial cells.. 2. 1982
55,000-dalton, retrovirus-associated, cell membrane glycoprotein: purification and quantitative measurements of expression in viruses, cells, and tissues.. 1. 1981

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