Toxicology and Applied Pharmacology
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Antimicrobial agent triclosan disrupts mitochondrial structure, revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation.
Sex-specific differences in hyperoxic lung injury in mice: Implications for acute and chronic lung disease in humans.
Prenatal administration of the cytochrome P4501A inducer, Β-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: Implications for bronchopulmonary dysplasia (BPD) in premature infants.
Estrogen-induced breast cancer: Alterations in breast morphology and oxidative stress as a function of estrogen exposure.
Ventricular preexcitation sensitive to flecainide in late stage chick embryo ECGs: 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs inotropic but not chronotropic or dromotropic responses to isoproterenol and confers resistance to flecainide.
TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4, an enzyme lacking arachidonic acid epoxygenase activity, in myocardium and vascular endothelium.
Transcriptional activation of avian CYP1A4 and CYP1A5 by 2,3,7,8- tetrachlorodibenzo-p-dioxin: Differences in gene expression and regulation compared to mammalian CYP1A1 and CYP1A2.
2,3,7,8-tetrachlorodibenzo-p-dioxin induction of cytochrome P450- dependent arachidonic acid metabolism in mouse liver microsomes: Evidence for species-specific differences in responses.
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces hepatic cytochrome P450-dependent arachidonic acid epoxygenation in diverse avian orders: Regioisomer selectivity and immunochemical comparison of the TCDD-induced P450s to CYP1A4 and 1A5.
Excitotoxins, aging, and environmental neurotoxins: Implications for understanding human neurodegenerative diseases.
Polychlorinated aromatic hydrocarbon lethality, mixed-function oxidase induction, and uroporphyrinogen decarboxylase inhibition in the chick embryo: Dissociation of dose-response relationships.
Coordinate induction of cytochrome P-448 mediated mixed function oxidases and histopathologic changes produced acutely in chick embryo liver by polychlorinated biphenyl congeners.
Toxicity of 5-hydroxytryptoline in rats.
Teratogenic effects of trimethadione and dimethadione in the chick embryo.
The antidiuretic effect of narcotic analgesics in the mouse.
The development of tolerance to the antidiuretic effect of morphine in the mouse.
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