Zachary Grinspan   Associate Professor of Healthcare Policy and Research

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My research focuses on how analysis of large clinical and administrative datasets can answer core questions for children with epilepsy.  Below are areas of interest and sample projects.


* Rare Epilepsies in New York City (RENYC).  Rare epilepsies are a devastating group of diseases that begin in childhood, and are often associated with profound neurologic, medical, and psychiatric disabilities. We are working to collect electronic physician notes from five academic medical centers in New York City to identify cases in order to understand the essential epidemiology of this vulnerable and medically complex population (incidence, prevalence, mortality, comorbidity burden, and use of health services). Using new methods for surveillance, we will develop and characterize an easy-to-share tool to find rare epilepsies through an automated search of clinical notes.

* Sudden Unexpected Death in Epilepsy (SUDEP).  We are reviewing physician notes to understand how and when physicians counsel children with epilepsy about SUDEP.


* Comparative Effectiveness for infantile Spasms.   Infantile Spasms is a devastating epilepsy of infancy that can cause permanent neurodevelopment disability. There are three recommended treatments: ACTH, oral steroids, and vigabatrin. We are comparing these treatments for infantile spasms using several large datasets. 

* Early Life Epilepsies.  We are comparing the effectiveness of commonly used medications for children aged 0 - 3 with new onset epilepsy.


* NeuroPICU Dashboard. We are developing tailored visualizations of clinical data to improve physician decision making for children with neurological diseases in the ICU. We aim to integrate cardio-pulmonary physiology, neurophysiology, EEG, medications, and laboratory values into a unified dashboard to assist ongoing care.

* EEG Signal Processing.  We are exploring novel techniques to view and interpret EEG signals using spectral analysis.


* We are studying how children with epilepsy use health services (doctor visits, imaging, EEGs, etc.).  

Students and residents are always welcome to contact me to join ongoing projects, or to develop new ones.


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