Xin-Yun Huang   Professor of Physiology and Biophysics

Cellular Signaling and Molecular Medicine

The research in our laboratory is focused on several cellular signaling pathways, their physiological functions, and their applications in disease treatments.

1.  G-protein Signaling

Our long-term goal of this research program is to discover the signaling pathways regulated by G-proteins and the physiological functions of these modulations.  Currently we focus on the signaling mechanisms and functions by which G-protein G13 controls blood vessel formation. We are investigating the roles of G13 in endothelial cell proliferation, remodeling and migration.

2.  Structural Studies on the Activation of G-proteins by GPCRs

The signaling from G protein-coupled receptors (GPCRs) to G-proteins is one of the main signaling systems used in biology.  Although we have an outline of this signaling system, the molecular bases for many steps in this signaling cascade are poorly understood.  One of the pressing issues is how GPCRs activate G-proteins.  We use biochemical and biophysical approaches to investigate this question.

3.  Tumor Metastasis

Tumor metastasis is the major cause of death of cancer patients, responsible for more than 90% of all cancer deaths.  We focus on tumor metastasis, more specifically, on tumor cell migration and invasion.  Our long-term goal of this research program is to reveal the critical proteins for tumor cell migration and invasion, and to use these proteins as targets for drug development to block tumor metastasis.  Currently we focus on fascin which is critical for tumor cell migration, invasion and metastasis.

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Background

Primary Affiliation

  • Weill Cornell Medical College, Cornell University

Contact

full name

  • Dr. Xin-Yun Huang

primary email

  • xyhuang@med.cornell.edu