Shen, Wen H.

Publications

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selected publications

STYK1/NOK affects cell cycle late mitosis and directly interacts with anaphase-promoting complex activator CDH1. Heliyon. 2022 Academic Article GET IT
Chemotherapy-induced cytokines and prognostic gene signatures vary across breast and colorectal cancer. American journal of cancer research. 2021 Academic Article GET IT
Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy. Journal for immunotherapy of cancer. 2021 Academic Article GET IT
Senescence and Cancer. Cancer translational medicine. 2018 Academic Article GET IT
PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregation. BioEssays : news and reviews in molecular, cellular and developmental biology. 2017 Information Resource GET IT
Times cited: 49
Cell Cycle Control by PTEN. Journal of molecular biology. 2017 Information Resource GET IT
Times cited: 78
NOK mediates glycolysis and nuclear PDC associated histone acetylation. Frontiers in bioscience (Landmark edition). 2017 Academic Article GET IT
Times cited: 8
PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis. Nature communications. 2016 Academic Article GET IT
Times cited: 38
PTEN regulates PLK1 and controls chromosomal stability during cell division. Cell cycle (Georgetown, Tex.). 2016 Academic Article GET IT
Times cited: 31
Genome maintenance in the context of 4D chromatin condensation. Cellular and molecular life sciences : CMLS. 2016 Information Resource GET IT
Times cited: 11
PTEN stabilizes TOP2A and regulates the DNA decatenation. Scientific reports. 2015 Academic Article GET IT
Times cited: 39
PTEN regulates DNA replication progression and stalled fork recovery. Nature communications. 2015 Academic Article GET IT
Times cited: 61
PTEN interacts with histone H1 and controls chromatin condensation. Cell reports. 2014 Academic Article GET IT
Times cited: 76
PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism. Cell metabolism. 2014 Academic Article GET IT
Times cited: 179
PTEN C-terminal deletion causes genomic instability and tumor development. Cell reports. 2014 Academic Article GET IT
Times cited: 66
CREB is a novel nuclear target of PTEN phosphatase. Cancer research. 2011 Academic Article GET IT
Times cited: 111
PTEN: a new guardian of the genome. Oncogene. 2008 Information Resource GET IT
Times cited: 268
A molecular link between E2F-1 and the MAPK cascade. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 29
Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell. 2007 Academic Article GET IT
Times cited: 728
C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts. Endocrinology. 2006 Academic Article GET IT
Times cited: 36
Mitogen-activated protein kinase phosphatase 2: a novel transcription target of p53 in apoptosis. Cancer research. 2006 Academic Article GET IT
Times cited: 43
Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide. Endocrinology. 2004 Academic Article GET IT
Times cited: 86
IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblasts. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 82
IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 21
Tumor necrosis factor alpha inhibits insulin-like growth factor I-induced hematopoietic cell survival and proliferation. Endocrinology. 2004 Academic Article GET IT
Times cited: 12
Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 33
Cytokine-hormone interactions: tumor necrosis factor alpha impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblasts. Endocrinology. 2003 Academic Article GET IT
Times cited: 90
Proinflammatory cytokines block growth of breast cancer cells by impairing signals from a growth factor receptor. Cancer research. 2002 Academic Article GET IT
Times cited: 74
Interleukin-10 in the brain. Critical reviews in immunology. 2001 Information Resource GET IT
Times cited: 309

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Research

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Funding awarded

Dynamics of Immune Response in Irradiated Rectal Cancer awarded by National Cancer Institute Co-Investigator 2022 - 2027
Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory awarded by United States Department of Defense Co-Investigator 2021 - 2025
Mechanisms of Endometrial Cancer Disparities in African Americans awarded by New York Genome Center Inc. Co-Investigator 2021 - 2024

Creating a 3D TNBC model of PTEN deficiency to discover immunoregulatory tumor epitopes awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2023 - 2024

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Background

education and training

Ph.D., University of Illinois 2003
M.S., Xi'an Jiaotong University (China) 1998
B.S., Nanjing University (China) 1989

Contact

full name

Wen H. Shen

primary email

wes2007@med.cornell.edu

VIVO Weill Cornell Medical College

Wen H. Shen Associate Professor of Cell Biology in Radiation Oncology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email