Susan Mathew   Professor of Clinical Pathology and Laboratory Medicine

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Dr. Susan Mathew received her undergraduate education and Ph. D. in Human Genetics in her native country of India in 1981. She subsequently received post-doctoral training at the Institute of Human Genetics in Freiburg, West Germany and returned to India to direct a cytogenetics laboratory, which she did for the next six years. In 1990 she immigrated to the United States to work as a Research Associate in Cancer Genetics under the mentorship and tutelage of Dr. Raji Chaganti at Memorial Sloan Kettering Cancer Center. In 1995, she was appointed Assistant Member in the Department of Pathology at St. Jude Children’s Research Hospital. She was promoted to Associate Member, Department of Pathology at that institution in March, 2002. Dr. Mathew is one of only a small handful of individuals in the United States who is certified in Clinical Cytogenetics by the American Board of Medical Genetics.


Dr. Mathew is widely respected in the United States as an outstanding cancer and molecular cytogeneticist. She is particularly well known and respected for her expertise in the cytogenetic diagnosis of human leukemias and lymphomas and for her scholarly contributions to the literature concerning this topic.


Dr. Mathew currently spends 50 percent of her time in clinical service and 10 percent of her time in administration. The remainder of her time is spent in clinical research. However, despite her heavy clinical responsibility, Dr. Mathew has authored more than 60 original scientific papers, the vast majority of which are concerned with the cytogenetic and molecular cytogenetic analysis of human neoplasms. Many of these publications were generated while under the mentorship of Dr. Chaganti However, following her relocation to the St. Jude Children’s Research Hospital in 1995, Dr. Mathew continued to contribute significantly to the scientific literature, publishing multiple scientific articles in Leukemia, Genes Chromosomes and Cancer, and Cancer Genetics and Cytogenetics. Dr. Mathew was first author on many of these papers. The majority of the papers that she published between 1999 and 2002 involved molecular cytogenetic analysis of pediatric leukemias. This included the single largest study ever performed on the cytogenetic abnormalities associated with the t(12;21) translocation positive acute lymphoblastic leukemias (Leukemia 13:1325,1999) and the use of multicolor spectral karyotyping to identify novel translocations in acute lymphoblastic leukemia (Leukemia 15:468,2001). Dr. Mathew has also contributed several chapters to the medical literature.


In summary, Dr. Susan Mathew is currently regarded as one of a small number of outstanding diagnostic molecular cytogeneticists in the United States.


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