selected publications
- Di-indenopyridines as topoisomerase II-selective anticancer agents: Design, synthesis, and structure-activity relationships. Bioorganic & medicinal chemistry. 2023 Academic Article GET IT
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Synthesis and evaluation of 7-(3-aminopropyloxy)-substituted flavone analogue as a topoisomerase IIα catalytic inhibitor and its sensitizing effect to enzalutamide in castration-resistant prostate cancer cells.
European journal of medicinal chemistry.
2022
Academic Article
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Times cited: 1 -
Design, synthesis, and biological evaluation of novel HSP27 inhibitors to sensitize lung cancer cells to clinically available anticancer agents.
Bioorganic chemistry.
2022
Academic Article
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Times cited: 2 -
Interrupting specific hydrogen bonds between ELF3 and MED23 as an alternative drug resistance-free strategy for HER2-overexpressing cancers.
Journal of advanced research.
2022
Academic Article
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Times cited: 3 -
Hypoxia-induced ELF3 promotes tumor angiogenesis through IGF1/IGF1R.
EMBO reports.
2022
Academic Article
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Times cited: 11 -
Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships.
Bioorganic & medicinal chemistry letters.
2022
Academic Article
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Times cited: 2 -
AK-I-190, a New Catalytic Inhibitor of Topoisomerase II with Anti-Proliferative and Pro-Apoptotic Activity on Androgen-Negative Prostate Cancer Cells.
International journal of molecular sciences.
2021
Academic Article
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Times cited: 8 -
Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors.
European journal of medicinal chemistry.
2021
Academic Article
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Times cited: 5 -
Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison.
European journal of medicinal chemistry.
2021
Academic Article
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Times cited: 6 -
4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure-activity relationships.
Bioorganic chemistry.
2021
Academic Article
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Times cited: 3 -
Identification of Indicators for Preterm Birth Using Retinoid Metabolites.
Metabolites.
2021
Academic Article
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Times cited: 7 -
Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers.
Pharmaceutics.
2021
Academic Article
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Times cited: 2 -
Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent.
Chemical communications (Cambridge, England).
2020
Academic Article
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Times cited: 8 -
Specific Roles of HSP27 S15 Phosphorylation Augmenting the Nuclear Function of HER2 to Promote Trastuzumab Resistance.
Cancers.
2020
Academic Article
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Times cited: 14 -
Plumbagin Suppresses Pulmonary Fibrosis via Inhibition of p300 Histone Acetyltransferase Activity.
Journal of medicinal food.
2020
Academic Article
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Times cited: 11 -
A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform.
Chemical communications (Cambridge, England).
2019
Academic Article
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Times cited: 13 -
Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2-b]pyridinol Derivatives as Potent Topoisomerase IIα-Targeted Chemotherapeutic Agents for Breast Cancer.
Journal of medicinal chemistry.
2019
Academic Article
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Times cited: 18 -
Recent therapeutic trends and promising targets in triple negative breast cancer.
Pharmacology & therapeutics.
2019
Review
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Times cited: 139 -
Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shock protein 27.
European journal of medicinal chemistry.
2017
Academic Article
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Times cited: 11