Theodore H Schwartz   Professor of Neurological Surgery

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Optical imaging of epilepsy and functional neocortex

The focus of our lab is on studying the initiation and propagation of epilepsy in the necortex of rats and humans. We are also interested in uncovering neurovascular coupling mechanisms. We are exploring several acute and chronic rat models of neocortical epilepsy in the lab. Simultaneous optical imaging and electrophysiology are used to investigate the relationship between blood volume, hemeglobin oxygenation and the underlying neurophysiology of epileptiform events. The laboratory has expertise in intrinsic signal imaging, voltage sensitive dye imaging and calcium imaging. Our human studies are done in the operating room on patients who are undergoing brain surgery for epilepsy. We are able to image human cortex during spontaneous epileptic events as well as cortical stimulation and somatosensory stimulation.

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Primary Affiliation

  • Weill Cornell Medical College, Cornell University