Mitra, Sankar

Selected publications

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 6
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis. Nature Communications. 2018 Academic Article GET IT
Times cited: 13
Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress. DNA Repair. 2018 Academic Article GET IT
Times cited: 2
Pre-replicative repair of oxidized bases maintains fidelity in mammalian genomes: The cowcatcher role of NEIL1 DNA glycosylase. Genes. 2017 Academic Article GET IT
Times cited: 3
Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex. Nucleic Acids Research. 2017 Academic Article GET IT
Times cited: 18
8-Oxoguanine DNA glycosylase1–driven DNA repair—A paradoxical role in lung aging. Mechanisms of Ageing and Development. 2017 Academic Article GET IT
Times cited: 9
Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis. Oncotarget. 2017 Academic Article GET IT
Times cited: 4
Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease. Journal of Alzheimer's Disease. 2017 Academic Article GET IT
Times cited: 9
Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?. Mechanisms of Ageing and Development. 2017 Review GET IT
Times cited: 7
DNA damage responses in central nervous system and age-associated neurodegeneration. Mechanisms of Ageing and Development. 2017 Editorial Article GET IT
Times cited: 2
Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A. Nucleic Acids Research. 2017 Academic Article GET IT
Times cited: 3
Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing. DNA Repair. 2016 Academic Article GET IT
Times cited: 9
Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions. Oncotarget. 2016 Academic Article GET IT
Times cited: 4
Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice. Mutation Research - DNA Repair. 2015 Academic Article GET IT
Times cited: 2
The C-terminal domain (CTD) of human DNA glycosylase NEIL1 is required for forming BERosome repair complex with DNA replication proteins at the replicating genome: Dominant negative function of the CTD. Journal of Biological Chemistry. 2015 Academic Article GET IT
Times cited: 19
New paradigms in the repair of oxidative damage in human genome: Mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins. Cellular and Molecular Life Sciences. 2015 Review GET IT
Times cited: 19
A tribute in memory of Richard B. (Dick) Setlow (1921-2015). DNA Repair. 2015 In Process GET IT
Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: Implications for the regulation of mitochondrial function. Nucleic Acids Research. 2014 Academic Article GET IT
Times cited: 35
New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases. Biomolecules. 2014 Review GET IT
Times cited: 18
Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway. Journal of Immunology. 2014 Academic Article GET IT
Times cited: 50
Oxidative stress: An essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiological Reviews. 2014 Review GET IT
Times cited: 509
Systems approaches to modeling chronic mucosal inflammation. BioMed Research International. 2013 Academic Article GET IT
Times cited: 26
Deficiency in Repair of the Mitochondrial Genome Sensitizes Proliferating Myoblasts to Oxidative Damage. PLoS ONE. 2013 Academic Article GET IT
Times cited: 26
Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 51
Dual Regulatory Roles of Human AP-Endonuclease (APE1/Ref-1) in CDKN1A/p21 Expression. PLoS ONE. 2013 Academic Article GET IT
Times cited: 14
The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions. Journal of Molecular Biology. 2013 Academic Article GET IT
Times cited: 30
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes. Journal of Biological Chemistry. 2013 Academic Article GET IT
Times cited: 45
The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites. Journal of Biological Chemistry. 2012 Academic Article GET IT
Times cited: 19
Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction. Journal of Biological Chemistry. 2012 Academic Article GET IT
Times cited: 27
Oxidized base damage and single-strand break repair in mammalian genomes: Role of disordered regions and posttranslational modifications in early enzymes. Progress in Molecular Biology and Translational Science. 2012 Review GET IT
Times cited: 36
Activation of Ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine. Journal of Biological Chemistry. 2012 Academic Article GET IT
Times cited: 76
Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction. Journal of Neuroscience Research. 2012 Academic Article GET IT
Times cited: 25
Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex. Journal of Hypertension. 2012 Academic Article GET IT
Times cited: 11
Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases. Mechanisms of Ageing and Development. 2012 Review GET IT
Times cited: 84
Human DNA glycosylase NEIL1's interactions with downstream repair proteins is critical for efficient repair of oxidized DNA base damage and enhanced cell survival. Biomolecules. 2012 Academic Article GET IT
Times cited: 18
Does evening sun increase the risk of skin cancer?. Proceedings of the National Academy of Sciences of the United States of America. 2011 Comment GET IT
Times cited: 5
Impaired integrity of DNA after recovery from inflammation causes persistent dysfunction of colonic smooth muscle. Gastroenterology. 2011 Academic Article GET IT
Times cited: 16
Apoptosis induced by persistent single-strand breaks in mitochondrial genome: Critical role of EXOG (5′-exo/endonuclease) in their repair. Journal of Biological Chemistry. 2011 Academic Article GET IT
Times cited: 94
Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer. Cell Research. 2011 Academic Article GET IT
Times cited: 23
Oxidative genome damage and its repair in neurodegenerative diseases: Function of transition metals as a double-edged sword. Journal of Alzheimer's Disease. 2011 Review GET IT
Times cited: 40
Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria. American Journal of Pathology. 2011 Academic Article GET IT
Times cited: 15
Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. Journal of Biological Chemistry. 2011 Academic Article GET IT
Times cited: 82
Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1. Oncogene. 2011 Academic Article GET IT
Times cited: 71
Functions of disordered regions in mammalian early base excision repair proteins. Cellular and Molecular Life Sciences. 2010 Review GET IT
Times cited: 42
Specific inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: Potential etiological linkage to neurodegenerative diseases. Journal of Biological Chemistry. 2010 Academic Article GET IT
Times cited: 37
RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures. DNA Repair. 2010 Academic Article GET IT
Times cited: 38
Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury. Mechanisms of Ageing and Development. 2010 Academic Article GET IT
Times cited: 44
DNA base excision repair: A recipe for survival. 2009 Chapter GET IT
Times cited: 2
p53-mediated down-regulation of the human DNA repair gene O ⁶-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor. Anticancer Research. 2009 Academic Article GET IT
Times cited: 64
Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA. Nucleic Acids Research. 2009 Academic Article GET IT
Times cited: 79
Acetylation of Apurinic/Apyrimidinic Endonuclease-1 Regulates Helicobacter pylori-Mediated Gastric Epithelial Cell Apoptosis. Gastroenterology. 2009 Academic Article GET IT
Times cited: 36
Tumor necrosis factor (TNF)-α-induced IL-8 expression in gastric epithelial cells: Role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1. Cytokine. 2009 Academic Article GET IT
Times cited: 21
Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein. Antioxidants and Redox Signaling. 2009 Review GET IT
Times cited: 149
Genome-Wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells. Proteomics. 2009 Academic Article GET IT
Times cited: 64
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. Molecular and Cellular Biology. 2008 Academic Article GET IT
Times cited: 84
Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease. Journal of Biological Chemistry. 2008 Academic Article GET IT
Times cited: 68
Long patch base excision repair in mammalian mitochondrial genomes. Journal of Biological Chemistry. 2008 Academic Article GET IT
Times cited: 106
Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme. DNA Repair. 2008 Academic Article GET IT
Times cited: 22
Unusual Role of a Cysteine Residue in Substrate Binding and Activity of Human AP-Endonuclease 1. Journal of Molecular Biology. 2008 Academic Article GET IT
Times cited: 24
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage. Nucleic Acids Research. 2008 Academic Article GET IT
Times cited: 80
Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil. Biochemical and Biophysical Research Communications. 2008 Academic Article GET IT
Times cited: 34
Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen: The potential for replication-associated repair of oxidized bases in mammalian genomes. Journal of Biological Chemistry. 2008 Academic Article GET IT
Times cited: 107
A special issue on DNA damage responses and genome maintenance. Cell Research. 2008 Editorial Article GET IT
APE1/Ref-1 regulates PTEN expression mediated by Egr-1. Free Radical Research. 2008 Academic Article GET IT
Times cited: 43
Discrimination of lesion removal of N-methylpurine-DNA glycosylase revealed by a potent neutralizing monoclonal antibody. DNA Repair. 2008 Academic Article GET IT
Times cited: 7
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell Research. 2008 Review GET IT
Times cited: 379
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. Journal of Biological Chemistry. 2007 Academic Article GET IT
Times cited: 79
MGMT: A personal perspective. DNA Repair. 2007 Review GET IT
Times cited: 32
Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein. DNA Repair. 2007 Academic Article GET IT
Times cited: 72
The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase. Nucleic Acids Research. 2007 Academic Article GET IT
Times cited: 54
NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. DNA Repair. 2006 Academic Article GET IT
Times cited: 86
Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1. Journal of Immunology. 2006 Academic Article GET IT
Times cited: 28
Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells. Mitochondrion. 2006 Academic Article GET IT
Times cited: 35
Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells. Nucleic Acids Research. 2006 Academic Article GET IT
Times cited: 102
Purification and Characterization of NEIL1 and NEIL2, Members of a Distinct Family of Mammalian DNA Glycosylases for Repair of Oxidized Bases. Methods in Enzymology. 2006 Article GET IT
Times cited: 19
LVMH Recherche Symposium on mitochondria October 6th, 2005 Paris. Bioscience Reports. 2006 Academic Article GET IT
Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo. Molecular and Cellular Biology. 2006 Academic Article GET IT
Times cited: 116
Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species. Journal of Biological Chemistry. 2005 Academic Article GET IT
Times cited: 57
Effect of aging on intracellular distribution of abasic (AP) endonuclease 1 in the mouse liver. Mechanisms of Ageing and Development. 2005 Academic Article GET IT
Times cited: 28
Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1). Nucleic Acids Research. 2005 Academic Article GET IT
Times cited: 59
ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. Journal of Clinical Investigation. 2005 Academic Article GET IT
Times cited: 254
Two essential but distinct functions of the mammalian abasic endonuclease. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 166
Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein. Journal of Biological Chemistry. 2004 Academic Article GET IT
Times cited: 26
Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution. Mechanisms of Ageing and Development. 2004 Academic Article GET IT
Times cited: 51
Stimulation of DNA glycosylase activity of OGG1 by NEIL1: Functional collaboration between two human DNA glycosylases. Biochemistry. 2004 Academic Article GET IT
Times cited: 53
Helicobacter pylori and H 2O 2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells. Gastroenterology. 2004 Academic Article GET IT
Times cited: 71
Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity. Nucleic Acids Research. 2004 Academic Article GET IT
Times cited: 61
AP endonuclease-independent DNA base excision repair in human cells. Molecular Cell. 2004 Academic Article GET IT
Times cited: 325
The major role of human AP-endonuclease homolog Apn2 in repair of abasic sites in Schizosaccharomyces pombe. Nucleic Acids Research. 2004 Academic Article GET IT
Times cited: 31
Acetylation of Human AP-Endonuclease 1, A Critical Enzyme in DNA Repair and Transcription Regulation. Methods in Enzymology. 2003 Article GET IT
Times cited: 13
Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2. Journal of Biological Chemistry. 2003 Academic Article GET IT
Times cited: 247
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. EMBO Journal. 2003 Academic Article GET IT
Times cited: 136
Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage. Toxicology. 2003 Article GET IT
Times cited: 160
Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress. Toxicology. 2003 Academic Article GET IT
Times cited: 52
Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 93
CpG methylation-dependent repression of the human O⁶-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration. Carcinogenesis. 2003 Academic Article GET IT
Times cited: 50
The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications. Carcinogenesis. 2003 Academic Article GET IT
Times cited: 57
Solution structure of a DNA duplex containing 8-hydroxy-2′-deoxyguanosine opposite deoxyguanosine. Journal of Molecular Biology. 2003 Academic Article GET IT
Times cited: 19
Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions. Journal of Biological Chemistry. 2002 Academic Article GET IT
Times cited: 244
Binding of specific DNA base-pair mismatches by N-methylpurine-DNA glycosylase and its implication in initial damage recognition. Journal of Molecular Biology. 2002 Academic Article GET IT
Times cited: 22
Choreography of oxidative damage repair in mammalian genomes. Free Radical Biology and Medicine. 2002 Article GET IT
Times cited: 114
Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 374
Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. Nucleic Acids Research. 2002 Academic Article GET IT
Times cited: 62
Multifaceted resistance of gliomas to temozolomide. Clinical Cancer Research. 2002 Academic Article GET IT
Times cited: 91
Preface. Progress in nucleic acid research and molecular biology. 2001 Editorial Article
Session 4 DNA glycosylases: Specificity and mechanisms. Progress in nucleic acid research and molecular biology. 2001 Review GET IT
Times cited: 15
Oxidative DNA damage and 8-hydroxy-2-deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancer. Molecular Carcinogenesis. 2001 Academic Article GET IT
Times cited: 58
Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli. Nucleic Acids Research. 2001 Academic Article GET IT
Times cited: 90
Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: Potential coordination of the initial steps in base excision repair. Nucleic Acids Research. 2001 Academic Article GET IT
Times cited: 294
Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in Vivo functions. Progress in nucleic acid research and molecular biology. 2001 Article GET IT
Times cited: 101
Spatial expression of a DNA repair gene, N-methylpurine-DNA glycosylase (MPG) during development in mice. Anticancer Research. 2000 Academic Article GET IT
Times cited: 16
Regulation of the human O⁶-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300. Journal of Biological Chemistry. 2000 Academic Article GET IT
Times cited: 47
Characterization of a novel 8-oxoguanine-DNA glycosylase activity in Escherichia coli and identification of the enzyme as endonuclease VIII. Journal of Biological Chemistry. 2000 Academic Article GET IT
Times cited: 82
Requirement for human AP endonuclease 1 for repair of 3'-blocking damage at DNA single-strand breaks induced by reactive oxygen species. Carcinogenesis. 2000 Academic Article GET IT
Times cited: 156
Deficiency of N-methylpurine-DNA-glycosylase expression in nonparenchymal cells, the target cell for vinyl chloride and vinyl fluoride. Mutation Research - DNA Repair. 2000 Academic Article GET IT
Times cited: 15
Mitochondrial DNA damage and a hypoxic response are induced by CoCl2 in rat neuronal PC12 cells. Nucleic Acids Research. 2000 Academic Article GET IT
Times cited: 130
Mutation of a unique aspartate residue abolishes the catalytic activity but not substrate binding of the mouse N-methylpurine-DNA glycosylase (MPG). Journal of Biological Chemistry. 2000 Academic Article GET IT
Times cited: 7
DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination. Nature. 2000 Academic Article GET IT
Times cited: 470
Acquired alkylating drug resistance of a human ovarian carcinoma cell line is unaffected by altered levels of pro- and anti-apoptotic proteins. Oncogene. 2000 Academic Article GET IT
Times cited: 23
Characterization of a chlorambucil-resistant human ovarian carcinoma cell line overexpressing glutathione S-transferase μ. Biochemical Pharmacology. 1999 Academic Article GET IT
Times cited: 41
Intragenic suppression of an active site mutation in the human apurinic/apyrimidinic endonuclease. Journal of Molecular Biology. 1999 Academic Article GET IT
Times cited: 42
Activation of human O⁶-methylguanine-DNA methyltransferase gene by glucocorticoid hormone. Oncogene. 1999 Academic Article GET IT
Times cited: 61
APE/Ref-1 responses to ischemia in rat brain. NeuroReport. 1998 Academic Article GET IT
Times cited: 35
APE/Ref-1 responses to oxidative stress in aged rats. Journal of Neuroscience Research. 1998 Academic Article GET IT
Times cited: 55
The presence of two distinct 8-oxoguanine repair enzymes in human cells: Their potential complementary roles in preventing mutation. Nucleic Acids Research. 1998 Academic Article GET IT
Times cited: 155
Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Genes and Development. 1998 Academic Article GET IT
Times cited: 166
Regulation of expression of the DNA repair gene-O⁶-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling. Cancer Research. 1998 Academic Article GET IT
Times cited: 79
Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Journal of Biological Chemistry. 1998 Academic Article GET IT
Times cited: 204
Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 356
Deletion analysis of human AP-endonuclease: Minimum sequence required for the endonuclease activity. Carcinogenesis. 1998 Academic Article GET IT
Times cited: 69
Reversible folding of Ada protein (O⁶-methylguanine-DNA methyltransferase) of Escherichia coli. Biochemistry. 1998 Academic Article GET IT
Times cited: 3
Specific interaction of wild-type and truncated mouse N-methylpurine- DNA glycosylase with ethenoadenine-containing DNA. Biochemistry. 1998 Academic Article GET IT
Times cited: 51
Molecular cloning and characterization of the promoter of the human N-methylpurine-DNA glycosylase (MPG) gene. Carcinogenesis. 1997 Academic Article GET IT
Times cited: 8
Complexities of DNA Base Excision Repair in Mammalian Cells. Molecules and Cells. 1997 Review GET IT
Times cited: 121
Amplification of the DNA repair gene O⁶-methylguanine-DNA methyltransferase associated with resistance to alkylating drugs in a mammalian cell line. Journal of Biological Chemistry. 1997 Academic Article GET IT
Times cited: 20
Specific recognition of O⁶-methylguanine in DNA by active site mutants of human O⁶-methylguanine-DNA methyltransferase. Biochemistry. 1997 Academic Article GET IT
Times cited: 52
Quantitative reverse transcriptase polymerase chain reaction for measuring the N-methylpurine-DNA glycosylase mRNA level in rodent cells. Analytical Biochemistry. 1997 Academic Article GET IT
Times cited: 9
Mutations of O⁶-methylguanine-DNA methyltransferase gene in esophageal cancer tissue from Northern China. International Journal of Cancer. 1997 Academic Article GET IT
Times cited: 38
Adaptive response in human cells: Induction of AP-Endonuclease by sublethal levels of reactive oxygen-species. FASEB Journal. 1996 Academic Article
Cloning and characterization of the mouse alpha globin cluster and a new hypervariable marker. Mammalian Genome. 1996 Academic Article GET IT
Times cited: 5
Induction of genes involved in dna alkylation repair in rat hepatoma cells. FASEB Journal. 1996 Academic Article
Times cited: 1
Minimum size of active human O⁶-methylguanine-dna methyltransference (MGMT); substrate binding parallels mgmt activity. FASEB Journal. 1996 Academic Article
Promoter function of the human ap-endonuclease. FASEB Journal. 1996 Academic Article
The domains of mammalian base excision repair enzyme w-methylpurine-dna glycosylase: Interaction, conformational change and role in dna-binding and damage recognition. FASEB Journal. 1996 Academic Article
Negative regulation of the major human AP-endonuclease, a multifunctional protein. Biochemistry. 1996 Academic Article GET IT
Times cited: 67
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes. Carcinogenesis. 1996 Academic Article GET IT
Times cited: 105
The domains of mammalian base excision repair enzyme N-methylpurine-DNA glycosylase. Interaction, conformational change, and role in DNA binding and damage recognition. Journal of Biological Chemistry. 1996 Academic Article GET IT
Times cited: 20
Distinct substrate preference of human and mouse N-methylpurine-DNA glycosylases. Carcinogenesis. 1996 Academic Article GET IT
Times cited: 39
DNA repair and its regulatory pathways in cancer pharmacology. Medecine sciences : M/S. 1996 Academic Article
Times cited: 3
A comparative study of the biochemical properties of human and mouse recombinant O⁶-methylguanine-DNA methyltransferases. Carcinogenesis. 1995 Academic Article GET IT
Times cited: 15
Enhanced host cell reactivation capacity and expression of DNA repair genes in human breast cancer cells resistant to bi-functional alkylating agents. Mutation Research - DNA Repair. 1995 Academic Article GET IT
Times cited: 32
Structural Organization of the Mouse DNA Repair Gene, N-Methylpurine-DNA Glycosylase. DNA and Cell Biology. 1995 Academic Article GET IT
Times cited: 21
Purification and biochemical characterization of recombinant N-methylpurine-DNA glycosylase of the mouse. Biochemistry. 1994 Academic Article GET IT
Times cited: 48
Cloning of a marsupial DNA photolyase gene and the lack of related nucleotide sequences in placental mammals. Nucleic Acids Research. 1994 Academic Article GET IT
Times cited: 73
1,N⁶-ethenoadenine is preferred over 3-methyladenine as substrate by a cloned human N-methylpurine-DNA glycosylase (3-methyladenine-DNA glycosylase). Biochemistry. 1994 Academic Article GET IT
Times cited: 92
Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 134
Brain and liver targeted overexpression of O⁶-methylguanine DNA methyltransferase in transgenic mice. Carcinogenesis. 1993 Academic Article GET IT
Times cited: 15
Regulation of repair of alkylation damage in mammalian genomes. Progress in nucleic acid research and molecular biology. 1993 Review GET IT
Times cited: 181
Cytosine methylation and suppression of O⁶-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts. Oncology Research. 1992 Academic Article GET IT
Times cited: 34
Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in chinese hamster ovary cells. Carcinogenesis. 1992 Academic Article GET IT
Times cited: 65
Characterization of cDNA encoding mouse DNA repair protein O⁶- methylguanine-DNA methyltransferase and high-level expression of the wild- type and mutant proteins in Escherichia coli. Biochemistry. 1992 Academic Article GET IT
Times cited: 26
Chromosomal localization of human O⁶-methylguanine-DNA methyltransferase (MGMT) gene by in situ hybridization. Mutagenesis. 1992 Academic Article GET IT
Times cited: 44
Correlation between DNA methylation and expression of O⁶-methylguanine-DNA methyltransferase gene in cultured human tumor cells. Mutation Research - DNA Repair. 1992 Academic Article GET IT
Times cited: 41
Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase. Journal of Biological Chemistry. 1991 Academic Article GET IT
Times cited: 129
Inducibility of the DNA repair gene encoding O⁶-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments. Molecular and Cellular Biology. 1991 Academic Article GET IT
Times cited: 125
Characterization of the promoter region of the human O⁶-methylguanine-DNA methyltransferase gene. Nucleic Acids Research. 1991 Academic Article GET IT
Times cited: 128
Mutations induced by ionizing radiation in a plasmid replicated in human cells. I. Similar, nonrandom distribution of mutations in unirradiated and X-irradiated DNA. Radiation Research. 1991 Academic Article GET IT
Times cited: 36
Mutations induced by ionizing radiation in a plasmid replicated in human cells. II. Sequence analysis of α-particle-induced point mutations. Radiation Research. 1991 Academic Article GET IT
Times cited: 25
Transfection and expression of human O⁶-methylguanine-DNA methyltransferase (MGMT) cDNA in chinese hamster cells: The role of MGMT in protection against the genotoxic effects of alkylating agents. Carcinogenesis. 1991 Academic Article GET IT
Times cited: 235
Expression of O⁶-methylguanine-DNA methyltransferase in malignant human glioma cell lines. Carcinogenesis. 1991 Academic Article GET IT
Times cited: 39
The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells transfected with human DNA. Mutation Research - DNA Repair. 1991 Academic Article GET IT
Times cited: 4
Structural and immunological comparison of indigenous human O⁶-methylguanine-DNA methyltransferase with that encoded by a cloned cDNA. Journal of Biological Chemistry. 1991 Academic Article GET IT
Times cited: 22
The origin of O⁶-methylguanine-DNA methyltransferase in Chinese hamster overy cells transfected with human DNA. Mutation Research - DNA Repair. 1991 Academic Article GET IT
Times cited: 14
The role of O⁶-alkylguanine in cell killing and mutagenesis in chinese hamster ovary cells. Carcinogenesis. 1991 Academic Article GET IT
Times cited: 38
Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O⁶-alkylguanine. Proceedings of the National Academy of Sciences of the United States of America. 1990 Academic Article GET IT
Times cited: 260
N‐methyl‐N‐nitrosourea‐lnduced mutations in a shuttle plasmid replicated in human cells. Molecular Carcinogenesis. 1990 Academic Article GET IT
Times cited: 18
Physicochemical studies of human O⁶‐methylguanine‐DNA methyltransferase. European Journal of Biochemistry. 1990 Academic Article GET IT
Times cited: 35
Age-dependent modulation of tissue-specific repair activity for 3-methyladenine and O⁶-methylguanine in DNA in inbred mice. Mechanisms of Ageing and Development. 1989 Academic Article GET IT
Times cited: 44
O⁶-Alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts. Journal of Neurosurgery. 1989 Academic Article GET IT
Times cited: 136
Site-directed mutation of the Escherichia coli ada gene: Effects of substitution of methyl acceptor cysteine-321 by histidine in Ada protein. Journal of Bacteriology. 1989 Academic Article GET IT
Times cited: 13
Mutagenic potential of modified DNA precursors in vivo: Fate of O⁶-methyldeoxyguanosine triphosphate in Chinese hamster ovary cells. Indian Journal of Biochemistry and Biophysics. 1988 Academic Article GET IT
Times cited: 5
Rapid, large-scale purification and characterization of 'ada protein' (0⁶ methylguanine-DNA methyltransferase) of E.coli. Nucleic Acids Research. 1988 Academic Article GET IT
Times cited: 22
High-level expression of the cloned ada gene of Escherichia coli by deletion of its regulatory sequence. Gene. 1988 Academic Article GET IT
Times cited: 5
Effect of polyvalent metal ions on the reactivity of human o-methylguanine-dna methyltransferase. Carcinogenesis. 1988 Academic Article GET IT
Times cited: 22
Tissue-specific variation in repair activity for 3-methyladenine in DNA in two stocks of mice. Mutation Research - DNA Repair. 1988 Academic Article GET IT
Times cited: 19
Role of carcinogen-modified deoxynucleotide precursors in mutagenesis. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1988 Academic Article GET IT
Times cited: 14
Function of Lys-166 of Rhodospirillum rubrum ribulosebisphosphate carboxylase/oxygenase as examined by site-directed mutagenesis. Journal of Biological Chemistry. 1987 Academic Article GET IT
Times cited: 38
Purification and some properties of human DNA-O⁶-methylguanine methyltransferase. Journal of Biosciences. 1987 Academic Article GET IT
Times cited: 20
Site-directed mutagenesis to determine essential residues of ribulose-bisphosphate carboxylase of Rhodospirillum rubrum. Journal of Biosciences. 1987 Academic Article GET IT
Controversies in basic science: Do carcinogen-modified deoxynucleotide precursors contribute to cellular mutagenesis?. Cancer Investigation. 1987 Academic Article GET IT
Times cited: 8
Nonessentiality of histidine 291 of Rhodospirillum rubrum ribulose-bisphosphate carboxylase/oxygenase as determined by site-directed mutagenesis. Journal of Biological Chemistry. 1986 Academic Article GET IT
Times cited: 36
Cell cycle-dependent modulation of o-methylguanine-dna methyltransferse in c3h/10t1/2 cells. Carcinogenesis. 1986 Academic Article GET IT
Times cited: 25
Proteins tightly associated with the termini of replicative form DNA of Kilham rat virus, an autonomous parvovirus. Proceedings of the National Academy of Sciences of the United States of America. 1985 Academic Article GET IT
Times cited: 7
Structure of the capsid of Kilham rat virus from small-angle neutron scattering. Biochemistry. 1984 Academic Article GET IT
Times cited: 4
Kinetics of incorporation of O⁶-methyldeoxyguanosine monophosphate during in vitro DNA synthesis. Biochemistry. 1984 Academic Article GET IT
Times cited: 28
Lack of induction of o-methylguanine-dna methyltransferase in mammalian cells treated with n-methyl-n' -nitro-n-nitrosoguanidine. Carcinogenesis. 1984 Academic Article GET IT
Times cited: 51
Autonomous parvovirus LuIII encapsidates equal amounts of plus and minus DNA strands. Journal of Virology. 1984 Academic Article GET IT
Times cited: 16
Base-pairing properties of O⁶-methylguanine in template DNA during in vitro DNA replication. Journal of Biological Chemistry. 1984 Academic Article GET IT
Times cited: 130
Characterization of proteins tightly associated with replicative form DNA of Kilham rat virus. Federation Proceedings. 1984 Academic Article
O⁶-Methylguanine-DNA methyltransferase in human cells. Mutation Research DNA Repair Reports. 1984 Academic Article GET IT
Times cited: 75
Distribution of restriction enzyme sites in the bovine parvovirus genome and comparison to other autonomous parvoviruses. Journal of General Virology. 1983 Academic Article GET IT
Times cited: 2
Repair of O⁶-methylguanine in DNA by demethylation is lacking in Mer^- human tumor cell strains. Carcinogenesis. 1983 Academic Article GET IT
Times cited: 153
Replication and Demethylation of O6-Methylguanine in DNA. Progress in nucleic acid research and molecular biology. 1983 Academic Article GET IT
Times cited: 4
Electron microscopic comparison of the sequences of single-stranded genomes of mammalian parvoviruses by heteroduplex mapping. Journal of Molecular Biology. 1983 Academic Article GET IT
Times cited: 4
Purification and properties of O6-methylguanine-DNA transmethylase from rat liver. Journal of Biological Chemistry. 1983 Academic Article GET IT
Times cited: 217
Quantitation of O⁶-methylguanine-DNA methyltransferase in HeLa cells. Mutation Research Letters. 1983 Academic Article GET IT
Times cited: 52
Comparative physicochemical and biological properties of two strains of Kilham rat virus, a non-defective parvovirus. Journal of General Virology. 1982 Academic Article GET IT
Times cited: 8
Mutagenesis of bacteriophage T7 in vitro by incorporation of O⁶-methylguanine during DNA synthesis. Proceedings of the National Academy of Sciences of the United States of America. 1982 Academic Article GET IT
Times cited: 47
O⁶-Methylguanine-DNA methyltransferase in wild-type and ada mutants of Escherichia coli. Journal of Bacteriology. 1982 Academic Article GET IT
Times cited: 43
Calibration of denaturing agarose gels for molecular weight estimation of DNA: Size determination of the single‐stranded genomes of parvoviruses. Electrophoresis. 1982 Academic Article GET IT
Times cited: 2
Restriction map of the single-stranded DNA genome of Kilham rat virus strain 171, a nondefective parvovirus. Journal of Virology. 1981 Academic Article GET IT
Times cited: 3
DNA replication in viruses. Annual Review of Genetics. 1980 Review GET IT
Times cited: 7
Demethylation of O⁶-methylguanine synthetic DNA polymer by an inducible activity in Escherichia coli. Biochemical and Biophysical Research Communications. 1980 Academic Article GET IT
Times cited: 133
Comparison of specific binding sites for Escherichia coli RNA polymerase with naturally occurring hairpin regions in single-stranded DNA of coliphage M13. Journal of Biological Chemistry. 1978 Academic Article GET IT
Times cited: 2
Structure of nascent replicative form DNA of coliphage M13. Proceedings of the National Academy of Sciences of the United States of America. 1978 Academic Article GET IT
Times cited: 1
Isolation and characterization of naturally occurring hairpin structures in single-stranded DNA of coliphage M13. Biochemical and Biophysical Research Communications. 1977 Academic Article GET IT
Times cited: 1
Base-unpaired regions in supercoiled replicative form DNA of coliphage M13. Journal of Biological Chemistry. 1977 Academic Article GET IT
Times cited: 25
Electron microscopic studies of bacteriophage M13 DNA replication. Journal of Virology. 1977 Academic Article GET IT
Times cited: 7
The role of DNA polymerase I-associated 5′-exonuclease in replication of coliphage M13 replicative-form DNA. Biochemical and Biophysical Research Communications. 1977 Academic Article GET IT
Times cited: 1
The Role of Escherichia coli dnaA Gene and Its Integrative Suppression in M 13 Coliphage DNA Synthesis. European Journal of Biochemistry. 1976 Academic Article GET IT
Times cited: 5
Strand separation of DNA induced by ultraviolet irradiation in vitro. BBA Section Nucleic Acids And Protein Synthesis. 1974 Academic Article GET IT
Times cited: 14
Transcriptional control of M13 phage DNA replication. Basic life sciences. 1974 Academic Article GET IT
Role of dna genes of Escherichia coli in M13 phage replication. Virology. 1973 Academic Article GET IT
Times cited: 7
Inhibition of M13 phage synthesis by rifampicin in some rifampicin-resistant Escherichia coli mutants. Virology. 1972 Academic Article GET IT
Times cited: 1
Susceptibility of E. coli K-12 to actinomycin D after Infection with phage M13. Nature. 1970 Academic Article GET IT
Times cited: 4
Increased fragility of Escherichia coli after infection with bacteriophage M13. Journal of Virology. 1970 Academic Article GET IT
Times cited: 12
Denaturation of DNA after X-irradiation in vitro. Biochemical and Biophysical Research Communications. 1970 Academic Article GET IT
Times cited: 6
Enzymic synthesis of deoxyribonucleic acid. XXII. Replication of a circular single-stranded DNA template by DNA polymerase of Escherichia coli. Journal of Molecular Biology. 1967 Academic Article
Times cited: 6
Biophysical properties of RNA from turnip yellow mosaic virus. Journal of Molecular Biology. 1965 Academic Article GET IT
Times cited: 18
Interaction of polyamines with turnip yellow mosaic virus RNA. Biochemical and Biophysical Research Communications. 1963 Academic Article
Times cited: 10
Lecithin-splitting enzyme of Vibrio E1 Tor. Nature. 1961 Academic Article GET IT
Times cited: 1

VIVO Weill Cornell Medical College

Sankar Mitra Professor of Biochemistry in Radiation Oncology

Publications

Selected publications

Background

Education and Training