Petraitiene, Ruta

Publications

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selected publications

Exploring the potential of bis(thiazol-5-yl)phenylmethane derivatives as novel candidates against genetically defined multidrug-resistant Staphylococcus aureus. PloS one. 2024 Academic Article GET IT
Synthesis of 3-((4-Hydroxyphenyl)amino)propanoic Acid Derivatives as Promising Scaffolds for the Development of Antimicrobial Candidates Targeting Multidrug-Resistant Bacterial and Fungal Pathogens. Antibiotics (Basel, Switzerland). 2024 Academic Article GET IT
Synthesis of 1-(2-Hydroxyphenyl)- and (3,5-Dichloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic Acid Derivatives as Promising Scaffolds for the Development of Novel Antimicrobial and Anticancer Agents. International journal of molecular sciences. 2023 Academic Article GET IT
Times cited: 3
Synthesis of Novel Benzenesulfonamide-Bearing Functionalized Imidazole Derivatives as Novel Candidates Targeting Multidrug-Resistant Mycobacterium abscessus Complex. Microorganisms. 2023 Academic Article GET IT
Times cited: 1
Synthesis and Development of N-2,5-Dimethylphenylthioureido Acid Derivatives as Scaffolds for New Antimicrobial Candidates Targeting Multidrug-Resistant Gram-Positive Pathogens. Antibiotics (Basel, Switzerland). 2023 Academic Article GET IT
Times cited: 1
Osteoarticular Mycoses. Clinical microbiology reviews. 2022 Review GET IT
Efficacy of Cefiderocol in Experimental Stenotrophomonas maltophilia Pneumonia in Persistently Neutropenic Rabbits. Antimicrobial agents and chemotherapy. 2022 Academic Article GET IT
Mechanistic Insights to Combating NDM- and CTX-M-Coproducing Klebsiella pneumoniae by Targeting Cell Wall Synthesis and Outer Membrane Integrity. Antimicrobial agents and chemotherapy. 2022 Academic Article GET IT
Times cited: 4
Synthesis of Novel Aminothiazole Derivatives as Promising Antiviral, Antioxidant and Antibacterial Candidates. International journal of molecular sciences. 2022 Academic Article GET IT
Times cited: 7
Synthesis, Biological Activity, and Molecular Modelling Studies of Naphthoquinone Derivatives as Promising Anticancer Candidates Targeting COX-2. Pharmaceuticals (Basel, Switzerland). 2022 Academic Article GET IT
Times cited: 7
Pharmacokinetics, Tissue Distribution, and Efficacy of VIO-001 (Meropenem/Piperacillin/Tazobactam) for Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia in Immunocompetent Rabbits with Chronic Indwelling Vascular Catheters. Antimicrobial agents and chemotherapy. 2021 Academic Article GET IT
Times cited: 3
Efficacy and Pharmacokinetics of Fosmanogepix (APX001) in the Treatment of Candida Endophthalmitis and Hematogenous Meningoencephalitis in Nonneutropenic Rabbits. Antimicrobial agents and chemotherapy. 2021 Academic Article GET IT
Times cited: 18
Antifungal efficacy of isavuconazole and liposomal amphotericin B in a rabbit model of Exserohilum rostratum meningoencephalitis: A preclinical paradigm for management of CNS phaeohyphomycosis. Medical mycology. 2021 Academic Article GET IT
Times cited: 3
Pharmacodynamics of Posaconazole in Experimental Invasive Pulmonary Aspergillosis: Utility of Serum Galactomannan as a Dynamic Endpoint of Antifungal Efficacy. Antimicrobial agents and chemotherapy. 2021 Academic Article GET IT
Times cited: 6
Modeling Invasive Aspergillosis: How Close Are Predicted Antifungal Targets?. Journal of fungi (Basel, Switzerland). 2020 Review GET IT
Times cited: 3
Antifungal Activity of Gepinacin Scaffold Glycosylphosphatidylinositol Anchor Biosynthesis Inhibitors with Improved Metabolic Stability. Antimicrobial agents and chemotherapy. 2020 Academic Article GET IT
Times cited: 5
Synthesis, ADMET Properties, and In Vitro Antimicrobial and Antibiofilm Activity of 5-Nitro-2-thiophenecarbaldehyde N-((E)-(5-Nitrothienyl)methylidene)hydrazone (KTU-286) against Staphylococcus aureus with Defined Resistance Mechanisms. Antibiotics (Basel, Switzerland). 2020 Academic Article GET IT
Times cited: 19
Combination Therapy with Ibrexafungerp (Formerly SCY-078), a First-in-Class Triterpenoid Inhibitor of (1→3)-β-d-Glucan Synthesis, and Isavuconazole for Treatment of Experimental Invasive Pulmonary Aspergillosis. Antimicrobial agents and chemotherapy. 2020 Academic Article GET IT
Times cited: 22
Pharmacokinetics and Efficacy of Ceftazidime-Avibactam in the Treatment of Experimental Pneumonia Caused by Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae in Persistently Neutropenic Rabbits. Antimicrobial agents and chemotherapy. 2020 Academic Article GET IT
Times cited: 8
Posaconazole Alone and in Combination with Caspofungin for Treatment of Experimental Exserohilum rostratum Meningoencephalitis: Developing New Strategies for Treatment of Phaeohyphomycosis of the Central Nervous System. Journal of fungi (Basel, Switzerland). 2020 Academic Article GET IT
Times cited: 4
Molecular Characterization of Uropathogenic Escherichia coli Reveals Emergence of Drug Resistant O15, O22 and O25 Serogroups. Medicina (Kaunas, Lithuania). 2019 Academic Article GET IT
Times cited: 11
Amphotericin B Penetrates into the Central Nervous System Through Focal Disruption of the Blood Brain Barrier in Experimental Hematogenous Candida Meningoencephalitis. Antimicrobial agents and chemotherapy. 2019 Academic Article GET IT
Times cited: 9
Ceftolozane-Tazobactam in the Treatment of Experimental Pseudomonas aeruginosa Pneumonia in Persistently Neutropenic Rabbits: Impact on Strains with Genetically Defined Mechanisms of Resistance. Antimicrobial agents and chemotherapy. 2019 Academic Article GET IT
Times cited: 11
Clinical Pharmacokinetics and Pharmacodynamics of Isavuconazole. Clinical pharmacokinetics. 2018 Information Resource GET IT
Times cited: 13
Pharmacokinetics and Comprehensive Analysis of the Tissue Distribution of Eravacycline in Rabbits. Antimicrobial agents and chemotherapy. 2018 Academic Article GET IT
Times cited: 14
In vitro combination therapy with isavuconazole against Candida spp. Medical mycology. 2017 Academic Article GET IT
Times cited: 8
Fungal Infections of the Central Nervous System in Children. Journal of the Pediatric Infectious Diseases Society. 2017 Information Resource GET IT
Times cited: 14
Combination Therapy with Isavuconazole and Micafungin for Treatment of Experimental Invasive Pulmonary Aspergillosis. Antimicrobial agents and chemotherapy. 2017 Academic Article GET IT
Times cited: 14
Translational Development and Application of (1→3)-β-d-Glucan for Diagnosis and Therapeutic Monitoring of Invasive Mycoses. International journal of molecular sciences. 2017 Information Resource GET IT
Times cited: 18
Nucleic acid amplification methodologies for the detection of pulmonary mold infections. Expert review of molecular diagnostics. 2017 Information Resource GET IT
Times cited: 7
Endpoint Assessment in Rabbit Models of Invasive Pulmonary Aspergillosis and Mucormycosis. Methods in molecular biology (Clifton, N.J.). 2017 Academic Article GET IT
Times cited: 3
Successful treatment of Aspergillus ventriculitis through voriconazole adaptive pharmacotherapy, immunomodulation, and therapeutic monitoring of cerebrospinal fluid (1→3)-β-D-glucan. Medical mycology. 2016 Review GET IT
Times cited: 28
Pharmacokinetics and Concentration-Dependent Efficacy of Isavuconazole for Treatment of Experimental Invasive Pulmonary Aspergillosis. Antimicrobial agents and chemotherapy. 2016 Academic Article GET IT
Times cited: 36
Entomophthoramycosis: a neglected tropical mycosis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2016 Review GET IT
Times cited: 57
Pharmacodynamics of isavuconazole in experimental invasive pulmonary aspergillosis: implications for clinical breakpoints. The Journal of antimicrobial chemotherapy. 2016 Academic Article GET IT
Times cited: 27
Candida Arthritis: Analysis of 112 Pediatric and Adult Cases. Open forum infectious diseases. 2015 Academic Article GET IT
Times cited: 30
Echinocandins: The Expanding Antifungal Armamentarium. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2015 Review GET IT
Times cited: 77
Intermittent Dosing of Micafungin Is Effective for Treatment of Experimental Disseminated Candidiasis in Persistently Neutropenic Rabbits. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2015 Academic Article GET IT
Times cited: 14
Effects of host response and antifungal therapy on serum and BAL levels of galactomannan and (1→3)-β-D-glucan in experimental invasive pulmonary aspergillosis. Medical mycology. 2015 Academic Article GET IT
Times cited: 24
(1→3)-β-d-Glucan in Cerebrospinal Fluid as a Biomarker for Candida and Aspergillus Infections of the Central Nervous System in Pediatric Patients. Journal of the Pediatric Infectious Diseases Society. 2015 Academic Article GET IT
Times cited: 57
Pharmacodynamics of amphotericin B deoxycholate, amphotericin B lipid complex, and liposomal amphotericin B against Aspergillus fumigatus. Antimicrobial agents and chemotherapy. 2015 Academic Article GET IT
Times cited: 30
Quantitative multiplexed detection of common pulmonary fungal pathogens by labeled primer polymerase chain reaction. Archives of pathology & laboratory medicine. 2014 Academic Article GET IT
Times cited: 14
In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important molds. Antimicrobial agents and chemotherapy. 2014 Academic Article GET IT
Times cited: 40
Host biomarkers of invasive pulmonary aspergillosis to monitor therapeutic response. Antimicrobial agents and chemotherapy. 2014 Academic Article GET IT
Times cited: 18
Environmental monitoring for Aspergillus fumigatus in association with an immunosuppressed rabbit model of pulmonary aspergillosis. Journal of the American Association for Laboratory Animal Science : JAALAS. 2013 Academic Article GET IT
Times cited: 2
A real-time PCR assay for rapid detection and quantification of Exserohilum rostratum, a causative pathogen of fungal meningitis associated with injection of contaminated methylprednisolone. Journal of clinical microbiology. 2013 Academic Article GET IT
Times cited: 28
Increased virulence of Cunninghamella bertholletiae in experimental pulmonary mucormycosis: correlation with circulating molecular biomarkers, sporangiospore germination and hyphal metabolism. Medical mycology. 2012 Academic Article GET IT
Times cited: 39
Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense. PloS one. 2011 Academic Article GET IT
Times cited: 52
Anidulafungin for neonatal hematogenous Candida meningoencephalitis: identification of candidate regimens for humans using a translational pharmacological approach. Antimicrobial agents and chemotherapy. 2011 Academic Article GET IT
Times cited: 33
Galactomannan antigenemia after infusion of gluconate-containing Plasma-Lyte. Journal of clinical microbiology. 2011 Academic Article GET IT
Times cited: 42
Molecular detection and species-specific identification of medically important Aspergillus species by real-time PCR in experimental invasive pulmonary aspergillosis. Journal of clinical microbiology. 2011 Academic Article GET IT
Times cited: 64
Early serum (1→3)-β-D-glucan levels in patients with burn injury. Mycoses. 2011 Academic Article GET IT
Times cited: 11
Protein expression profiles distinguish between experimental invasive pulmonary aspergillosis and Pseudomonas pneumonia. Proteomics. 2010 Academic Article GET IT
Times cited: 18
The initial 96 hours of invasive pulmonary aspergillosis: histopathology, comparative kinetics of galactomannan and (1->3) β-d-glucan and consequences of delayed antifungal therapy. Antimicrobial agents and chemotherapy. 2010 Academic Article GET IT
Times cited: 66
Combination therapy in treatment of experimental pulmonary aspergillosis: in vitro and in vivo correlations of the concentration- and dose- dependent interactions between anidulafungin and voriconazole by Bliss independence drug interaction analysis. Antimicrobial agents and chemotherapy. 2009 Academic Article GET IT
Times cited: 90
Diagnostic imaging of experimental invasive pulmonary aspergillosis. Medical mycology. 2009 Review GET IT
Times cited: 6
Detection of a molecular biomarker for zygomycetes by quantitative PCR assays of plasma, bronchoalveolar lavage, and lung tissue in a rabbit model of experimental pulmonary zygomycosis. Journal of clinical microbiology. 2008 Academic Article GET IT
Times cited: 109
Cerebrospinal fluid and plasma (1-->3)-beta-D-glucan as surrogate markers for detection and monitoring of therapeutic response in experimental hematogenous Candida meningoencephalitis. Antimicrobial agents and chemotherapy. 2008 Academic Article GET IT
Times cited: 55
Galactomannan antigenemia in pediatric oncology patients with invasive aspergillosis. The Pediatric infectious disease journal. 2008 Academic Article GET IT
Times cited: 60
Automated and manual methods of DNA extraction for Aspergillus fumigatus and Rhizopus oryzae analyzed by quantitative real-time PCR. Journal of clinical microbiology. 2008 Academic Article GET IT
Times cited: 39
The pharmacokinetics and pharmacodynamics of micafungin in experimental hematogenous Candida meningoencephalitis: implications for echinocandin therapy in neonates. The Journal of infectious diseases. 2008 Academic Article GET IT
Times cited: 154
Galactoxylomannan does not exhibit cross-reactivity in the platelia Aspergillus enzyme immunoassay. Clinical and vaccine immunology : CVI. 2007 Academic Article GET IT
Times cited: 16
Histoplasmosis-associated cross-reactivity in the BioRad Platelia Aspergillus enzyme immunoassay. Clinical and vaccine immunology : CVI. 2007 Academic Article GET IT
Times cited: 132
Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapy. The Journal of infectious diseases. 2006 Academic Article GET IT
Times cited: 106
Compartmentalized intrapulmonary pharmacokinetics of amphotericin B and its lipid formulations. Antimicrobial agents and chemotherapy. 2006 Academic Article GET IT
Times cited: 74
Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: in vitro and in vivo correlation. The Journal of infectious diseases. 2006 Academic Article GET IT
Times cited: 93
Characterization and comparison of galactomannan enzyme immunoassay and quantitative real-time PCR assay for detection of Aspergillus fumigatus in bronchoalveolar lavage fluid from experimental invasive pulmonary aspergillosis. Journal of clinical microbiology. 2006 Academic Article GET IT
Times cited: 70
Multidimensional volumetric imaging of pulmonary infiltrates for measuring therapeutic response to antifungal therapy in experimental invasive pulmonary aspergillosis. Antimicrobial agents and chemotherapy. 2006 Academic Article GET IT
Times cited: 16
Deoxycholate amphotericin B and amphotericin B lipid complex exert additive antifungal activity in combination with pulmonary alveolar macrophages against Fusarium solani. Mycoses. 2006 Academic Article GET IT
Times cited: 5
Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease. Antimicrobial agents and chemotherapy. 2006 Academic Article GET IT
Times cited: 66
Use of quantitative real-time PCR to study the kinetics of extracellular DNA released from Candida albicans, with implications for diagnosis of invasive Candidiasis. Journal of clinical microbiology. 2006 Academic Article GET IT
Times cited: 51
Compartmental pharmacokinetics and tissue distribution of the antifungal triazole ravuconazole following intravenous administration of its di-lysine phosphoester prodrug (BMS-379224) in rabbits. The Journal of antimicrobial chemotherapy. 2005 Academic Article GET IT
Times cited: 20
Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits. Antimicrobial agents and chemotherapy. 2005 Academic Article GET IT
Times cited: 30
Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis. Antimicrobial agents and chemotherapy. 2005 Academic Article GET IT
Times cited: 13
Detection of galactomannan antigenemia in patients receiving piperacillin-tazobactam and correlations between in vitro, in vivo, and clinical properties of the drug-antigen interaction. Journal of clinical microbiology. 2004 Academic Article GET IT
Times cited: 129
Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans. Antimicrobial agents and chemotherapy. 2004 Academic Article GET IT
Times cited: 33
Efficacy, safety, and plasma pharmacokinetics of escalating dosages of intravenously administered ravuconazole lysine phosphoester for treatment of experimental pulmonary aspergillosis in persistently neutropenic rabbits. Antimicrobial agents and chemotherapy. 2004 Academic Article GET IT
Times cited: 39
Comparative drug disposition, urinary pharmacokinetics, and renal effects of multilamellar liposomal nystatin and amphotericin B deoxycholate in rabbits. Antimicrobial agents and chemotherapy. 2003 Academic Article GET IT
Times cited: 15
Development and validation of a quantitative real-time PCR assay using fluorescence resonance energy transfer technology for detection of Aspergillus fumigatus in experimental invasive pulmonary aspergillosis. Journal of clinical microbiology. 2003 Academic Article GET IT
Times cited: 65
Experimental pulmonary aspergillosis due to Aspergillus terreus: pathogenesis and treatment of an emerging fungal pathogen resistant to amphotericin B. The Journal of infectious diseases. 2003 Academic Article GET IT
Times cited: 213
Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin. The Journal of infectious diseases. 2003 Academic Article GET IT
Times cited: 214
Macrophage colony-stimulating factor enhances phagocytosis and oxidative burst of mononuclear phagocytes against Penicillium marneffei conidia. FEMS immunology and medical microbiology. 2003 Academic Article GET IT
Times cited: 20
Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus. Antimicrobial agents and chemotherapy. 2002 Academic Article GET IT
Times cited: 44
Comparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits. Antimicrobial agents and chemotherapy. 2002 Academic Article GET IT
Times cited: 166
Antifungal efficacy of caspofungin (MK-0991) in experimental pulmonary aspergillosis in persistently neutropenic rabbits: pharmacokinetics, drug disposition, and relationship to galactomannan antigenemia. Antimicrobial agents and chemotherapy. 2002 Academic Article GET IT
Times cited: 173
Compartmental pharmacokinetics and tissue distribution of the antifungal echinocandin lipopeptide micafungin (FK463) in rabbits. Antimicrobial agents and chemotherapy. 2001 Academic Article GET IT
Times cited: 115
Cyclosporine A-induced mammary hyperplasia and hyperprolactinemia in New Zealand White rabbits. Comparative medicine. 2001 Academic Article GET IT
Times cited: 19
Pharmacokinetic and pharmacodynamic modeling of anidulafungin (LY303366): reappraisal of its efficacy in neutropenic animal models of opportunistic mycoses using optimal plasma sampling. Antimicrobial agents and chemotherapy. 2001 Academic Article GET IT
Times cited: 131
Antifungal activity and pharmacokinetics of posaconazole (SCH 56592) in treatment and prevention of experimental invasive pulmonary aspergillosis: correlation with galactomannan antigenemia. Antimicrobial agents and chemotherapy. 2001 Academic Article GET IT
Times cited: 157
Compartmental pharmacokinetics of the antifungal echinocandin caspofungin (MK-0991) in rabbits. Antimicrobial agents and chemotherapy. 2001 Academic Article GET IT
Times cited: 58
Dosage-dependent antifungal efficacy of V-echinocandin (LY303366) against experimental fluconazole-resistant oropharyngeal and esophageal candidiasis. Antimicrobial agents and chemotherapy. 2001 Academic Article GET IT
Times cited: 55
Comparative efficacy and distribution of lipid formulations of amphotericin B in experimental Candida albicans infection of the central nervous system. The Journal of infectious diseases. 2000 Academic Article GET IT
Times cited: 327
Compartmental pharmacokinetics and tissue distribution of multilamellar liposomal nystatin in rabbits. Antimicrobial agents and chemotherapy. 2000 Academic Article GET IT
Times cited: 22
Safety and efficacy of multilamellar liposomal nystatin against disseminated candidiasis in persistently neutropenic rabbits. Antimicrobial agents and chemotherapy. 1999 Academic Article GET IT
Times cited: 29
Antifungal activity of LY303366, a novel echinocandin B, in experimental disseminated candidiasis in rabbits. Antimicrobial agents and chemotherapy. 1999 Academic Article GET IT
Times cited: 105
Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits. Antimicrobial agents and chemotherapy. 1999 Academic Article GET IT
Times cited: 10
Antifungal efficacy, safety, and single-dose pharmacokinetics of LY303366, a novel echinocandin B, in experimental pulmonary aspergillosis in persistently neutropenic rabbits. Antimicrobial agents and chemotherapy. 1998 Academic Article GET IT
Times cited: 121
Compartmental pharmacokinetics and tissue drug distribution of the pradimicin derivative BMS 181184 in rabbits. Antimicrobial agents and chemotherapy. 1998 Academic Article GET IT
Times cited: 9

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Research

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Funding awarded

TARGETED CATALYTIC COMPLEMENT-ACTIVATING MOLECULES FOR TREATMENT OF EMERGING AND WHO PRIORITY BACTERIAL AND FUNGAL PATHOGENS awarded by Omeros Corporation Co-Investigator 2023 - 2028
Pharmacokinetics, Pharmacodynamics, Safety, and Efficacy of Innovative Dosing Schedules of AmBisome for Treatment of Experimental Invasive Pulmonary Aspergillosis: Establishing a Preclinical Foundation for Improved Patient Care and Outcome awarded by Gilead Sciences, Inc. Co-Investigator 2022 - 2024

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Background

education and training

M.D., Kaunas Medical School (Lithuania) 1985

Contact

full name

Ruta Petraitiene

primary email

rop2016@med.cornell.edu

VIVO Weill Cornell Medical College

Ruta Petraitiene Assistant Professor of Research in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email