Robert Lance Furler O'Brien Assistant Professor

Assistant Professor of Immunology in Medicine, Medicine , Weill Cornell Medical College 2018 -

The Furler O'Brien lab is focused on defining human T cell anatomy and physiology to understand HIV induced cellular pathology that leads to AIDS.

https://www.TCellBiology.com

Affiliation

head of

Furler O'Brien Laboratory PI 2018 -

Publications

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Co-Author Network

selected publications

HIV-1 Mediated Cortical Actin Disruption Mirrors ARP2/3 Defects Found in Primary T Cell Immunodeficiencies. 2024 GET IT
SARS-CoV-2 infection causes dopaminergic neuron senescence. Cell stem cell. 2024 Academic Article GET IT
HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing. Viruses. 2023 Academic Article GET IT
A History and Atlas of the Human CD4⁺ T Helper Cell. Biomedicines. 2023 Review GET IT
Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus. Nature microbiology. 2023 Academic Article GET IT
Times cited: 34
HIV-1 replication and latency are balanced by mTOR-driven cell metabolism. Frontiers in cellular and infection microbiology. 2022 Review GET IT
Transcriptome-wide association study of HIV-1 acquisition identifies HERC1 as a susceptibility gene. iScience. 2022 Academic Article GET IT
Activation of the Anti-Oxidative Stress Response Reactivates Latent HIV-1 Through the Mitochondrial Antiviral Signaling Protein Isoform MiniMAVS. Frontiers in immunology. 2021 Academic Article GET IT
Human Endogenous Retrovirus Expression Is Upregulated in the Breast Cancer Microenvironment of HIV Infected Women: A Pilot Study. Frontiers in oncology. 2020 Academic Article GET IT
Times cited: 8
A Novel HIV-1 Nef Mutation in a Primary Pediatric Isolate Impairs MHC-Class I Downregulation and Cytopathicity. AIDS research and human retroviruses. 2019 Academic Article GET IT
Nef-induced differential gene expression in primary CD4+ T cells following infection with HIV-1 isolates. Virus genes. 2019 Academic Article GET IT
The Intimate Relationship Between CD4+ T Cell Morphology and HIV-1 Infection. AIDS research and human retroviruses. 2019 Article GET IT
TGF-β Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction. Cancers. 2018 Information Resource GET IT
Times cited: 32
GLI2 regulates TGF-β1 in human CD4+ T cells: implications in cancer and HIV pathogenesis. PloS one. 2012 Academic Article GET IT
Times cited: 28
Signaling through the P38 and ERK pathways: a common link between HIV replication and the immune response. Immunologic research. 2010 Information Resource GET IT
Times cited: 51

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Research

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Funding awarded

Elucidating single cell changes in neurogenic brain regions during HIV and cannabinoid exposure awarded by National Institute on Drug Abuse Co-Investigator 2023 - 2028
Receptor for hyaluronan-mediated motility isoform B (RHAMM B) in Pancreatic Cancer Metastasis awarded by National Cancer Institute Co-Investigator 2022 - 2027
Integrative Single Cell Isoform And Chromatin Accessibility Mapping Of Chronic Opioid Exposure In Cognitive Brain Areas In HIV awarded by National Institute on Drug Abuse Co-Investigator 2021 - 2026
REACH: Research Enterprise to Advance a Cure for HIV awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2021 - 2026
Regulatory Crosstalk Between Human Endogenous Retroviruses, HIV, and EBV, in Lymphoma awarded by National Cancer Institute Co-Investigator 2021 - 2026

Elucidating single cell changes in neurogenic brain regions during HIV and cannabinoid exposure awarded by National Institute on Drug Abuse Co-Principal Investigator 2023 - 2028
HOPE - HIV Obstruction by Programmed Epigenetics awarded by National Heart, Lung, & Blood Institute Co-Principal Investigator 2021 - 2026

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Background

education and training

Ph.D., University of California, Los Angeles 2010
B.S., San Francisco State University 2004

Contact

full name

Robert Lance Furler O'Brien

primary email

rlf2001@med.cornell.edu

webpage

Furler O'Brien Lab

Phone