selected publications
- Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity. 2023 GET IT
- Capsaicin as an amphipathic modulator of NaV1.5 mechanosensitivity. Channels (Austin, Tex.). 2022 Academic Article GET IT
- Regulation of Gramicidin Channel Function Solely by Changes in Lipid Intrinsic Curvature. Frontiers in physiology. 2022 Academic Article GET IT
- Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism. Science advances. 2022 Academic Article GET IT
- Mechanisms underlying drug-mediated regulation of membrane protein function. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
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Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.
The Journal of general physiology.
2021
Academic Article
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Times cited: 31 -
Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers.
Bioorganic chemistry.
2020
Academic Article
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Times cited: 15 -
Gramicidin Increases Lipid Flip-Flop in Symmetric and Asymmetric Lipid Vesicles.
Biophysical journal.
2019
Academic Article
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Times cited: 41 -
Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels.
Biochemistry.
2018
Academic Article
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Times cited: 16 -
Stopped-Flow Fluorometric Ion Flux Assay for Ligand-Gated Ion Channel Studies.
2018
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Times cited: 10 -
Timing and Reset Mechanism of GTP Hydrolysis-Driven Conformational Changes of Atlastin.
Structure (London, England : 1993).
2017
Academic Article
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Times cited: 24 -
A general mechanism for drug promiscuity: Studies with amiodarone and other antiarrhythmics.
The Journal of general physiology.
2015
Academic Article
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Times cited: 33 -
Calcium ions open a selectivity filter gate during activation of the MthK potassium channel.
Nature communications.
2015
Academic Article
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Times cited: 31 -
Regulation of ion channel function by the host lipid bilayer examined by a stopped-flow spectrofluorometric assay.
Biophysical journal.
2014
Academic Article
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Times cited: 28 -
A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics.
The Journal of biological chemistry.
2014
Academic Article
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Times cited: 12 -
Phosphoinositides alter lipid bilayer properties.
The Journal of general physiology.
2013
Academic Article
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Times cited: 19 - Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. Faraday discussions. 2013 Academic Article GET IT
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Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery.
The Journal of general physiology.
2011
Academic Article
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Times cited: 45 -
Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation.
Pflugers Archiv : European journal of physiology.
2010
Academic Article
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Times cited: 65 -
Specificity of Gbetagamma signaling depends on Galpha subunit coupling with G-protein-sensitive K(+) channels.
Pharmacology.
2009
Academic Article
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Times cited: 5 -
Mass spectrometric analysis reveals a functionally important PKA phosphorylation site in a Kir3 channel subunit.
Pflugers Archiv : European journal of physiology.
2009
Academic Article
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Times cited: 13 -
A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P(2).
Nature chemical biology.
2008
Academic Article
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Times cited: 49 -
Specificity of Gbetagamma signaling to Kir3 channels depends on the helical domain of pertussis toxin-sensitive Galpha subunits.
The Journal of biological chemistry.
2007
Academic Article
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Times cited: 22 -
Alternative splicing switches potassium channel sensitivity to protein phosphorylation.
The Journal of biological chemistry.
2001
Academic Article
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Times cited: 181 -
Environments of the four tryptophans in the extracellular domain of human tissue factor: comparison of results from absorption and fluorescence difference spectra of tryptophan replacement mutants with the crystal structure of the wild-type protein.
Biophysical journal.
1995
Academic Article
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Times cited: 22