Richard A. Friedman   Professor of Clinical Psychiatry

  • (212) 746-5775 (Office)
  • (212) 746-5775 (Clinical)

Treatment of Chronic Depression

The current aims of Dr. Friedman's research are:

  1. To evaluate the efficacy of various antidepressant medications in the treatment of chronic depression.
  2. To study the effectiveness of long-term maintenance antidepressant treatment in chronic depression.
  3. To study the neurobiology of chronic depression.
  4. To study the social and occupational impairments of chronic depression.

Dr. Friedman is currently conducting the following clinical studies:

  • A double blind comparison of sertraline versus imipramine for "double depression" (i.e., dysthymia with major depression) and chronic major depression for both short and long-term treatment.

  • A double blind long-term study of desipramine versus placebo for dysthymia and other forms of chronic depression.

  • A tryptophan depletion paradigm, which acutely lowers brain serotonin levels, to study the role of serotonin in chronic depression.

Future plans include a study to simultaneously examine brain activity with MRI, behavior, and serotonin functions in patients with chronic depression.


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Select federal grants awarded

  • Comparative Effectiveness of a Second Generation Antipsychotic or a Mood Stabilizer for Bipolar Disorder  awarded by Agency for Healthcare Research & Quality Key Personnel 2010 - 2013


Primary Affiliation

  • Weill Cornell Medical College, Cornell University


full name

  • Dr. Richard A Friedman

primary email