Richard A. Friedman   Professor of Clinical Psychiatry

Phone
  • (212) 746-5775 (Office)
  • (212) 746-5775 (Clinical)

Treatment of Chronic Depression

The current aims of Dr. Friedman's research are:

  1. To evaluate the efficacy of various antidepressant medications in the treatment of chronic depression.
  2. To study the effectiveness of long-term maintenance antidepressant treatment in chronic depression.
  3. To study the neurobiology of chronic depression.
  4. To study the social and occupational impairments of chronic depression.

Dr. Friedman is currently conducting the following clinical studies:

  • A double blind comparison of sertraline versus imipramine for "double depression" (i.e., dysthymia with major depression) and chronic major depression for both short and long-term treatment.

  • A double blind long-term study of desipramine versus placebo for dysthymia and other forms of chronic depression.

  • A tryptophan depletion paradigm, which acutely lowers brain serotonin levels, to study the role of serotonin in chronic depression.

Future plans include a study to simultaneously examine brain activity with MRI, behavior, and serotonin functions in patients with chronic depression.

Publications

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Selected publications

  • How should the psychiatric profession respond to the recent mass killings?The American journal of psychiatry.  170:455-458. 2013 Editorial Article GET IT
    Times cited: 1
  • Grief, depression, and the DSM-5.  The New England journal of medicine.  366:1855-1857. 2012 Academic Article GET IT
    Times cited: 9
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  • Expanding the black box - depression, antidepressants, and the risk of suicide.  The New England journal of medicine.  356:2343-2346. 2007 Academic Article GET IT
    Times cited: 52
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  • Uncovering an epidemic--screening for mental illness in teens.  The New England journal of medicine.  355:2717-2719. 2006 Academic Article GET IT
    Times cited: 38
  • Violence and mental illness--how strong is the link?The New England journal of medicine.  355:2064-2066. 2006 Academic Article GET IT
    Times cited: 39
  • The changing face of teenage drug abuse--the trend toward prescription drugs.  The New England journal of medicine.  354:1448-1450. 2006 Academic Article GET IT
    Times cited: 45
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Research

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Select federal grants awarded

  • Comparative Effectiveness of a Second Generation Antipsychotic or a Mood Stabilizer for Bipolar Disorder  awarded by Agency for Healthcare Research & Quality Key Personnel 2010 - 2013

Background

Primary Affiliation

  • Weill Cornell Medical College, Cornell University

Contact

full name

  • Dr. Richard A Friedman

primary email

  • rafriedm@med.cornell.edu