Peter A. Goldstein   Professor of Anesthesiology

Phone
  • (212) 746-5325 (Office)

Molecular and cellular effects of general anesthetics

The overall focus of the lab is to better define the mechanisms by which a diverse group of pharmacological agents produce anesthesia. A potentially important region within the central nervous system (CNS) for contributing to the anesthetized state is the thalamus; it is a critical relay site for sensory information and it is considered to be an essential structure in the generation of consciousness and sleep. Inhibitory synaptic transmission helps regulate thalamic function, and the GABAA receptor is the primary receptor for mediating such transmission within the CNS. Many anesthetics are known to modulate the function of this receptor. This raises a number of basic questions, such as: What are the effects of different anesthetics on synaptic transmission in the thalamus? Do these drugs have unique effects in specific thalamic regions as a function of differences in receptor expression? GABA release is controlled by multiple mechanisms, including a variety of ion channels; is the function of those channels altered in the presence of anesthetics? The lab uses electrophysiological, immunohistochemical, and molecular biological techniques to address those issues.

Publications

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Selected publications

Research

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Select federal grants awarded

  • Anesthetic Effects on Thalamic Synaptic Transmission  awarded by National Institute of General Medical Sciences Principal Investigator 2004 - 2008
  • Derivation of Cerebral Cortical GABAergic Interneurons from Human iPS Cells Key Personnel 2009 - 2011
  • Gene Therapy for Treatment of Epilepsy  awarded by National Institute of Neurological Disorders & Stroke Principal Investigator Subaward 2009 - 2011

Background

Primary Affiliation

  • Weill Cornell Medical College, Cornell University

Contact

full name

  • Dr. Peter A Goldstein

primary email

  • pag2014@med.cornell.edu