Nicole Kucine   Person


Research Summary

I am currently working on two main projects with the Division of Pediatric Hematology/Oncology

Current Research Projects

Study of thrombosis in pediatric patients. There are a number of different reasons why children can get blood clots, and the more we understand about the causes, the better we will do at preventing them. This is a 3 part project, first looking retrospectively over the past 5 years to see how many blood clots our pediatric inpatients have gotten and then trying to figure out what the most common causes or associated findings were. We will also be going forward with a registry of all pediatric inpatients who develop blood clots to study their risk factors as well. We will ultimately be developing and implementing prophylaxis guidelines to help prevent our high-risk pediatric inpatients from developing blood clots.

Study on pediatric patients with Polycythemia Vera (PV) and essential Thrombocytosis (ET). These are diseases that are considered to be Myeloproliferative Neoplasms (MPN). They are conditions where the bone marrow produces abnormal numbers of blood cells, with PV being a condition of too many red blood cells and ET being a state of too many platelets. There are clear genetic causes for the majority of adult patients with these disorders, but this is not the case in pediatric patients (where the diseases are much rarer.) I will be colleting blood from our pediatric clinic patients with PV or ET and screening them for known genetic mutations, as well as evaluating genes that may play a role in myeloid disorders but have not yet been associated with PV or ET. This will hopefully lead to a better understanding of the pathogenesis of these diseases in children.