selected publications
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X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release.
Nature communications.
2020
Academic Article
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Times cited: 25 -
The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor.
Proceedings of the National Academy of Sciences of the United States of America.
2019
Academic Article
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Times cited: 19 -
A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport.
Nature communications.
2018
Academic Article
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Times cited: 33 -
Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter.
Biophysical journal.
2017
Academic Article
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Times cited: 13 -
Ligand modulation of sidechain dynamics in a wild-type human GPCR.
eLife.
2017
Academic Article
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Times cited: 67 -
The Allostery Landscape: Quantifying Thermodynamic Couplings in Biomolecular Systems.
Journal of chemical theory and computation.
2016
Academic Article
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Times cited: 24 -
Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters.
Chemical reviews.
2016
Information Resource
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Times cited: 49 -
Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles.
Biochemistry.
2016
Academic Article
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Times cited: 12 -
Computational approaches to detect allosteric pathways in transmembrane molecular machines.
Biochimica et biophysica acta.
2016
Academic Article
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Times cited: 47 -
Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus.
ACS chemical neuroscience.
2015
Academic Article
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Times cited: 83 - AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems. Entropy (Basel, Switzerland). 2015 Academic Article GET IT
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A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2.
Journal of the American Chemical Society.
2014
Academic Article
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Times cited: 65 -
NbIT--a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT.
PLoS computational biology.
2014
Academic Article
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Times cited: 78 -
The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site.
Journal of the American Chemical Society.
2013
Academic Article
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Times cited: 29