Mingming Hao   Assistant Professor of Biochemistry

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Type 2 diabetes mellitus is a multifactorial metabolic disorder resulting from the inability of pancreatic β-cells to produce adequate insulin to compensate for insulin resistance. The tipping point in the progression of prediabetes to diabetes is pancreatic β-cell dysfunction. The goals of my laboratory are to understand the molecular mechanisms underlying β-cell dysfunction and discover means to preserve and improve β-cell function in diabetes. Another goal is to generate functional islets derived from stem cell differentiation for those patients whose ultimate cure requires islet transplantation. Human pancreatic islets from both healthy and diabetic patients will be used in all aspects of our studies, in addition to animal models and cultured β-cells. Novel fluorescent probes, advanced imaging techniques and unique high-throughput platforms are used in our obesity-related diabetes research.

Publications

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Selected publications

Research

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Grants awarded

  • MiR-33b in Pancreatic Beta-Cell Dysfunction and Lipotoxicity  awarded by Qatar National Research Fund Principal Investigator 2016 - 2019
  • The Role of Phytosterols on Pancreatic Beta-Cell Function During Glucolipotoxicity  awarded by United States Department of Agriculture Key Personnel 2016 - 2018
  • Clinical and Translational Science Center (UL1) - Cooperative Agreement  awarded by National Center for Advancing Translational Sciences Key Personnel 2012 - 2017

Background

Contact

Primary Email

  • mhao@med.cornell.edu