Karajannis, Matthias

Publications

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selected publications

Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival. The Journal of biological chemistry. 2019 Academic Article GET IT
Times cited: 8
Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma. Science advances. 2018 Academic Article GET IT
Times cited: 98
Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma. Neuro-oncology. 2018 Academic Article GET IT
Times cited: 79
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma. Nature communications. 2018 Academic Article GET IT
Times cited: 45
Heterogeneity within the PF-EPN-B ependymoma subgroup. Acta neuropathologica. 2018 Academic Article GET IT
Times cited: 80
Effect of lapatinib on meningioma growth in adults with neurofibromatosis type 2. Journal of neuro-oncology. 2018 Academic Article GET IT
Times cited: 24
DNA methylation-based classification of central nervous system tumours. Nature. 2018 Academic Article GET IT
Times cited: 1662
Patterns of relapse for children with localized intracranial ependymoma. Journal of neuro-oncology. 2018 Academic Article GET IT
Times cited: 16
Programmed death ligand 1 expression and tumor infiltrating lymphocytes in neurofibromatosis type 1 and 2 associated tumors. Journal of neuro-oncology. 2018 Academic Article GET IT
Times cited: 52
Pre-treatment lymphopenia and indication of tumor-induced systemic immunosuppression in medulloblastoma. Journal of neuro-oncology. 2017 Academic Article GET IT
Times cited: 15
Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2. Cell reports. 2017 Academic Article GET IT
Times cited: 77
DNA Methylation-Based Classifier for Accurate Molecular Diagnosis of Bone Sarcomas. JCO precision oncology. 2017 Academic Article GET IT
Times cited: 38
Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome. Acta neuropathologica. 2017 Academic Article GET IT
Times cited: 165
Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2017 Academic Article GET IT
Times cited: 215
Endothelium-Independent Primitive Myxoid Vascularization Creates Invertebrate-Like Channels to Maintain Blood Supply in Optic Gliomas. The American journal of pathology. 2017 Academic Article GET IT
Times cited: 4
Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis. Molecular cancer therapeutics. 2017 Academic Article GET IT
Times cited: 31
The path forward: 2015 International Children's Tumor Foundation conference on neurofibromatosis type 1, type 2, and schwannomatosis. American journal of medical genetics. Part A. 2017 Conference Paper GET IT
Times cited: 5
Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis. Journal of neuro-oncology. 2017 Academic Article GET IT
Times cited: 18
Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway. Acta neuropathologica. 2016 Academic Article GET IT
Times cited: 171
Mutant IDH1 and thrombosis in gliomas. Acta neuropathologica. 2016 Academic Article GET IT
Times cited: 120
Utility of MRI versus tumor markers for post-treatment surveillance of marker-positive CNS germ cell tumors. Journal of neuro-oncology. 2016 Academic Article GET IT
Times cited: 2
Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 Academic Article GET IT
Times cited: 152
The promise of molecular profiling of choroid plexus tumors for diagnostic and prognostic stratification: where to go from here?. Neuro-oncology. 2016 Editorial Article GET IT
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. Cell. 2016 Academic Article GET IT
Times cited: 624
Pediatric Brain Tumors: Innovative Genomic Information Is Transforming the Diagnostic and Clinical Landscape. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015 Information Resource GET IT
Times cited: 168
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups. Cancer cell. 2015 Academic Article GET IT
Times cited: 824
Neurofibromatosis-related tumors: emerging biology and therapies. Current opinion in pediatrics. 2015 Information Resource GET IT
Times cited: 51
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. Cancer cell. 2014 Academic Article GET IT
Times cited: 176
Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas. Neuro-oncology. 2014 Academic Article GET IT
Times cited: 160
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nature genetics. 2014 Academic Article GET IT
Times cited: 465
Phase II study of everolimus in children and adults with neurofibromatosis type 2 and progressive vestibular schwannomas. Neuro-oncology. 2013 Academic Article GET IT
Times cited: 89
Recommendations for imaging tumor response in neurofibromatosis clinical trials. Neurology. 2013 Academic Article GET IT
Times cited: 100
Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target. Neuro-oncology. 2013 Academic Article GET IT
Times cited: 63
Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis. The Lancet. Oncology. 2013 Academic Article GET IT
Times cited: 282
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nature genetics. 2013 Academic Article GET IT
Times cited: 599
MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2. Neuro-oncology. 2012 Academic Article GET IT
Times cited: 54
Phase II trial of lapatinib in adult and pediatric patients with neurofibromatosis type 2 and progressive vestibular schwannomas. Neuro-oncology. 2012 Academic Article GET IT
Times cited: 130
Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus. EMBO reports. 2012 Information Resource GET IT
BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants. Journal of neuropathology and experimental neurology. 2012 Academic Article GET IT
Times cited: 138
Consensus recommendations for current treatments and accelerating clinical trials for patients with neurofibromatosis type 2. American journal of medical genetics. Part A. 2011 Academic Article GET IT
Times cited: 95
Prospective neuraxis MRI surveillance reveals a high risk of leptomeningeal dissemination in diffuse intrinsic pontine glioma. Journal of neuro-oncology. 2010 Academic Article GET IT
Times cited: 27
Bevacizumab in recurrent high-grade pediatric gliomas. Neuro-oncology. 2010 Academic Article GET IT
Times cited: 68
Overexpression and activation of epidermal growth factor receptor in hemangioblastomas. Journal of neuro-oncology. 2010 Academic Article GET IT
Times cited: 14
ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma. Neuro-oncology. 2010 Academic Article GET IT
Times cited: 75
The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death. Blood. 2007 Academic Article GET IT
Times cited: 65
Treatment-related myelodysplastic syndrome after chemotherapy for childhood low-grade astrocytoma. Journal of pediatric hematology/oncology. 2006 Article GET IT
Times cited: 1
Activation of FGFR1beta signaling pathway promotes survival, migration and resistance to chemotherapy in acute myeloid leukemia cells. Leukemia. 2006 Academic Article GET IT
Times cited: 38
Fetal stromal-dependent paracrine and intracrine vascular endothelial growth factor-a/vascular endothelial growth factor receptor-1 signaling promotes proliferation and motility of human primary myeloma cells. Cancer research. 2005 Academic Article GET IT
Times cited: 55
Epstein-Barr virus infection in Western European pediatric non-Hodgkin lymphomas. Blood. 2003 Article GET IT
Times cited: 15
Strict lymphotropism of Epstein-Barr virus during acute infectious mononucleosis in nonimmunocompromised individuals. Blood. 1997 Academic Article GET IT
Times cited: 68

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Background

education and training

M.S., New York University School of Medicine 2009
M.D., Free University of Berlin (Germany) 1997

Contact

full name

Matthias Karajannis

webpage

https://www.mskcc.org/cancer-care/doctors/matthias-karajannis

VIVO Weill Cornell Medical College

Matthias Karajannis Professor of Pediatrics

Publications

selected publications

Background

education and training

Contact

full name

webpage