Lora Hedrick Ellenson   Professor of Pathology and Laboratory Medicine

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Molecular genetics of endometrial carcinoma

Endometrial carcinoma is the most common malignancy of the female genital tract. Although it is often thought of as a single disease, there is epidemiological and clinicopathological evidence to support the view that it encompasses two broad categories of malignant epithelial tumors. Each broad category is composed predominantly of one histological type of endometrial carcinoma. The most common is uterine endometrioid carcinoma (UEC) and the other less common, but more aggressive type, is called uterine serous carcinoma (USC). We are currently using molecular approaches to define the differences, and the similarities, in the molecular genetic alterations of the two types of endometrial carcinoma and develop a genetic mouse model of endometrial tumorigenesis.


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Grants awarded

  • Mouse Model of Endometrial Tumorigenesis  awarded by National Cancer Institute Principal Investigator 2009 -
  • Origins of Ovarian Carcinoma  awarded by National Cancer Institute Principal Investigator Subaward 2015 -
  • Cancer-Prone Stem Cell Niches in Ovarian and Tubal Epithelia  awarded by Ovarian Cancer Research Fund Principal Investigator Subaward 2015 -



Primary Email

  • lhellens@med.cornell.edu