Laibaik Park   Assistant Professor of Research in Neuroscience

Neurovascular regulation.

Dr. Park is interested in understanding the regulatory mechanisms of neurovascular regulation that ensure a constant supply of blood to the brain at all times. To study the regulatory mechanisms in normal and diseased brain, Dr. Park employs a combination of in vivo and in vitro techniques, including craniotomy, electrophysiology, immunofluorescence, molecular biological techniques, confocal/multiphoton microscope, and behavioral analyses. The brain is highly dependent on a well-regulated blood supply in order to function normally. Abnormalities in the mechanisms are implicated in various cerebrovascular diseases, including stroke and Alzheimer’s and mixed dementia. Dr. Park's research focuses on a role of vascular factors, such as apolipoproteins, ß-amyloid, and tissue plasminogen activator, in the mechanisms of neurovascular regulation and the cellular and molecular mechanisms of cerebrovascular alterations leading to behavioral abnormalities. 


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Grants awarded

  • tPA Deficiency and Neurovascular Dysfunction in Models of Alzheimer''s Disease  awarded by American Heart Association Principal Investigator 2009 -
  • Overexpression of APP and Cerebrovascular Regulation  awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2012 -
  • Stalled Capillary Flow: A Novel Mechanism for Hypoperfusion in Alzheimer Disease  awarded by National Institute on Aging Principal Investigator Subaward 2015 -



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