Jenny Zhaoying Xiang   Professor of Research in Microbiology and Immunology

High Through-put Genomics Technologies

Jenny Xiang has served as the director of Genomics Resources Core Facility (GRCF, previously Microarray Core Facility) at Weill Cornell Medical College since year 2000. GRCF provides state of the art services in high through-put genomics technologies to researchers. The core services include experimental design, sample manipulation, instrumentation, data analysis, interpretation, and validation. The core facility consists of Agilent 2100 Bioanalyzer, Nanodrop, Qubit fluorometer, Taqman 7900HT real-time PCR machine, Covaris E220 High Performance Ultrasonicator, and high throughput next-generation sequencing (NGS) platforms including Illumina HiSeq4000/2500/NextSeq500/MiSeq. The goal of GRCF is to provide high quality services at low costs to the entire research community.

Next-generation sequencing (NGS), a non-Sanger-based DNA sequencing technology employs massively parallel sequencing that is able to produce hundreds of gigabases of high quality sequence information in a single run. Any nucleic acid samples can be sequenced on this platform. Because of its exceptional power and versatility, NGS has been used for a wide range of researches related to human diseases, including 1) whole genome sequencing; 2) all exome sequencing; 3) protein-DNA/RNA interactions (ChIP-Seq, CLIP, etc.); 4) small RNA discovery/expression; 5) RNA sequencing for SNP detection, expression analysis, and splice variant detection, and Targeted resequencing, etc. The services on this technology platform have been critical to the publications and securing of external grants by many investigators in the WCMC research community.


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