Jeffrey S Borer   Adjunct Professor of Cardiovascular Medicine in Cardiothoracic Surgery

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The biology of regurgitant valvular and ischemic diseases

The biology of regurgitant valvular diseases. Our research aims to elucidate the pathophysiology of myocardial dysfunction and heart failure in non-ischemic mitral or aortic regurgitation. Clinically measurable indices of these pathophysiological processes are employed in studies of clinical prognostication and definition of management decisions involving currently available therapies. Studies of underlying cellular and molecular mechanisms are expected to serve as a basis for subsequent development of new mechanism-specific therapies. Studies are carried out in patients and in animal models uniquely developed within this program, and involve investigations at the molecular, cellular, organ, whole animal ("preclinical"), and clinical levels.

Radionuclide-based evaluation of coronary artery disease. Our research aims to define precisely the prognostic implications of stress-induced variations in ventricular performance and perfusion, employing testing modalities developed in part by the investigator. These clinical studies are supported by a series of preclinical and basic science studies employing radiolabeled peptides in an effort to interrogate the biology of coronary atherosclerotic lesions. The latter studies, performed for several years in animals, recently have been begun in patients, with the goal of developing non-invasive methodology for direct detection of atherosclerotic lesions and definition of their structure.

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