Jordi Magrane   Associate Professor of Research in Neuroscience

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I am a cell biologist with an interest in mechanisms of neurodegeneration. I am intrigued by the role of mitochondria in neurodegeneration and, more specifically, in how impaired mitochondrial function and abnormal mitochondrial axonal transport cause disease. My overall goal is to understand the role of mitochondria in synaptic plasticity and axonal maintenance in health and disease. I have dedicated my efforts toward developing novel microscopy-based, live imaging assays to assess the role of mitochondrial dynamics to disease pathogenesis both in vitro (isolated neurons) and in vivo (whole mouse). Current research in the laboratory combines cellular and molecular approaches, together with mouse models and the power of live imaging techniques to investigate the role of mitochondria in health and disease. Imaging of mitochondria in a mouse overcomes the limitations of the use of isolated neurons, and allows for correlating mitochondrial transport and distribution abnormalities and disease progression in longitudinal studies.


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