James H. Kocsis   Professor of Psychiatry

  • (212) 746-5913 (Clinical)

Dysthymia and Chronic Depression States: Diagnosis and Treatment

The research group has been involved in a series of studies to validate diagnostic subtypes of chronic depression and investigate responsiveness to antidepressant medications in placebo-controlled clinical trials. The overall goals are to define depressive symptoms and syndromes that respond specifically to various classes of medication, and to discriminate between chronic depression syndromes which represent bio-genetically determined affective disorders versus learned character pathology.

Current studies in progress include:

  1. A long-term study of desipramine for pure dysthymia and double depression.
  2. A long-term study of sertraline versus imipramine for double depression and major depression--chronic.
  3. A long-term study of netazedone versus cognitive-behavioral therapy for chronic depression.
  4. A study of interpersonal psychotherapy versus desipramine for treatment of pure dysthymia.


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Selected publications


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Select federal grants awarded

  • REVAMP Follow-UP Study  awarded by National Institute of Mental Health Principal Investigator 2006 - 2009
  • Comparative Effectiveness of a Second Generation Antipsychotic or a Mood Stabilizer for Bipolar Disorder  awarded by Agency for Healthcare Research & Quality Principal Investigator Subaward 2010 - 2013
  • Treatment of Addictions: Biological Correlates  awarded by National Institute on Drug Abuse Principal Investigator Subaward 2012 - 2013
  • Biology of Addictive Diseases  awarded by National Institute on Drug Abuse Principal Investigator Subaward 2007 - 2012


Primary Affiliation

  • Weill Cornell Medical College, Cornell University


full name

  • Dr. James H Kocsis

primary email

  • jhk2002@med.cornell.edu