Rand, Jacob H.

Publications

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selected publications

Identification of thrombosis-related conformational binding epitopes on domain I of β2-glycoprotein I. Thrombosis research. 2024 Letter GET IT
COVID-19 and antiphospholipid antibodies: A position statement and management guidance from AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION). Lupus. 2021 Academic Article GET IT
Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis: Update of the guidelines for lupus anticoagulant detection and interpretation. Journal of thrombosis and haemostasis : JTH. 2020 Academic Article GET IT
Times cited: 22
SARS-CoV-2 Viral Load Predicts Mortality in Patients with and without Cancer Who Are Hospitalized with COVID-19. Cancer cell. 2020 Academic Article GET IT
Times cited: 163
Accelerated thrombin times are associated with thrombotic risk. American journal of hematology. 2020 Article GET IT
Absence of Distinct Immunohistochemical Distribution of Annexin A5, C3b, C4d, and C5b-9 in Placentas From Patients With Antiphospholipid Antibodies, Preeclampsia, and Systemic Lupus Erythematosus. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2019 Academic Article GET IT
Times cited: 5
Reimagining the antiphospholipid syndrome, an enigmatic thrombophilic disorder, through the looking glass of microscopic imaging. Histochemistry and cell biology. 2018 Information Resource GET IT
Times cited: 2
McMaster RARE-Bestpractices clinical practice guideline on diagnosis and management of the catastrophic antiphospholipid syndrome. Journal of thrombosis and haemostasis : JTH. 2018 Academic Article GET IT
Times cited: 46
The effect of hydroxychloroquine on haemostasis, complement, inflammation and angiogenesis in patients with antiphospholipid antibodies. Rheumatology (Oxford, England). 2018 Academic Article GET IT
Times cited: 35
Association of silent infarcts in sickle cell anemia with decreased annexin A5 resistance. Blood cells, molecules & diseases. 2017 Academic Article GET IT
Reduction of annexin A5 anticoagulant ratio identifies antiphospholipid antibody-positive patients with adverse clinical outcomes. Journal of thrombosis and haemostasis : JTH. 2017 Academic Article GET IT
Times cited: 7
A novel 2-stage approach that detects complement activation in patients with antiphospholipid antibody syndrome. Thrombosis research. 2017 Academic Article GET IT
Times cited: 10
Visualization of macro-immune complexes in the antiphospholipid syndrome by multi-modal microscopy imaging. Micron (Oxford, England : 1993). 2017 Academic Article GET IT
Times cited: 4
Cardiovascular risk factors are major determinants of thrombotic risk in patients with the lupus anticoagulant. BMC medicine. 2017 Academic Article GET IT
Times cited: 23
Inverted erythrocyte membranes demonstrate β2GPI-antiphospholipid antibody interactions and membrane crosslinking. Thrombosis research. 2016 Academic Article GET IT
Times cited: 2
A novel, rapid method to compare the therapeutic windows of oral anticoagulants using the Hill coefficient. Scientific reports. 2016 Academic Article GET IT
Times cited: 10
Efficacy of solvent/detergent plasma after storage at 2-8 °C for 5 days in comparison to other plasma products to improve factor V levels in factor V deficient plasma. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 2016 Academic Article GET IT
Times cited: 7
Antiphospholipid antibodies promote tissue factor-dependent angiogenic switch and tumor progression. The American journal of pathology. 2014 Academic Article GET IT
Times cited: 9
Relation of antiphospholipid antibodies to postmortem brain infarcts in older people. Circulation. 2014 Academic Article GET IT
Times cited: 11
A new trick for an ancient drug: quinine dissociates antiphospholipid immune complexes. Lupus. 2014 Academic Article GET IT
Times cited: 4
Atomic force microscopy: High resolution dynamic imaging of cellular and molecular structure in health and disease. Journal of cellular physiology. 2013 Academic Article GET IT
Times cited: 18
Annexin A5 anticoagulant activity in children with systemic lupus erythematosus and the association with antibodies to domain I of β2-glycoprotein I. Lupus. 2013 Academic Article GET IT
Times cited: 22
A child with acquired factor XIII deficiency: case report and literature review. Haemophilia : the official journal of the World Federation of Hemophilia. 2013 Information Resource GET IT
Times cited: 19
Viewing dynamic interactions of proteins and a model lipid membrane with atomic force microscopy. Methods in molecular biology (Clifton, N.J.). 2013 Academic Article GET IT
Times cited: 5
Antiphospholipid antibodies, brain infarcts, and cognitive and motor decline in aging (ABICMA): design of a community-based, longitudinal, clinical-pathological study. Neuroepidemiology. 2012 Academic Article GET IT
Times cited: 11
Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris. Nature communications. 2012 Academic Article GET IT
Times cited: 43
Insights into the pathophysiology of the antiphospholipid syndrome provided by atomic force microscopy. Micron (Oxford, England : 1993). 2012 Information Resource GET IT
Times cited: 7
Annexin A5 binds to lipopolysaccharide and reduces its endotoxin activity. mBio. 2012 Academic Article GET IT
Times cited: 47
Dos and don'ts in diagnosing antiphospholipid syndrome. Hematology. American Society of Hematology. Education Program. 2012 Information Resource GET IT
Times cited: 17
Prevalence of annexin A5 resistance in children and adolescents with rheumatic diseases. The Journal of rheumatology. 2011 Academic Article GET IT
Times cited: 3
Home free? Not after 3!. Blood. 2011 Article GET IT
Times cited: 1
Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression. American journal of obstetrics and gynecology. 2011 Academic Article GET IT
Times cited: 74
A new fish for the β2GPI hook: LPS!. Blood. 2011 Article GET IT
Times cited: 3
Resistance to annexin A5 anticoagulant activity in women with histories for obstetric antiphospholipid syndrome. American journal of obstetrics and gynecology. 2011 Academic Article GET IT
Times cited: 24
How I treat the acquired von Willebrand syndrome. Blood. 2011 Information Resource GET IT
Times cited: 194
Thrombophilia and the risk of thromboembolic events in women on oral contraceptives and hormone replacement therapy. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2010 Academic Article GET IT
Times cited: 19
A snappy new concept for APS. Blood. 2010 Article GET IT
Times cited: 2
Stroke secondary to carotid occlusion in a young man with nephrotic syndrome: Case description and review of the literature. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2010 Academic Article GET IT
Times cited: 2
The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: role in pregnancy losses and thrombosis. Lupus. 2010 Information Resource GET IT
Times cited: 102
Risk factors for clinical manifestations in carriers of Factor V Leiden and prothrombin gene mutations. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2010 Academic Article GET IT
Times cited: 6
Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug. Blood. 2009 Academic Article GET IT
Times cited: 209
The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study. Journal of thrombosis and haemostasis : JTH. 2009 Academic Article GET IT
Times cited: 226
Resistance to annexin A5 anticoagulant activity: a thrombogenic mechanism for the antiphospholipid syndrome. Lupus. 2008 Information Resource GET IT
Times cited: 49
Hydroxychloroquine directly reduces the binding of antiphospholipid antibody-beta2-glycoprotein I complexes to phospholipid bilayers. Blood. 2008 Academic Article GET IT
Times cited: 195
Imaging aspects of cardiovascular disease at the cell and molecular level. Histochemistry and cell biology. 2008 Information Resource GET IT
Times cited: 15
The antiphospholipid syndrome. Hematology. American Society of Hematology. Education Program. 2007 Information Resource GET IT
Times cited: 23
Correlation between antiphospholipid antibodies that recognize domain I of beta2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5. Blood. 2006 Academic Article GET IT
Times cited: 103
An evaluation of thrombophilia screening in an urban tertiary care medical center: A "real world" experience. American journal of clinical pathology. 2006 Academic Article GET IT
Times cited: 29
Analysis of circulating annexin A5 parameters during pregnancy: absence of differences between women with recurrent spontaneous pregnancy losses and controls. American journal of obstetrics and gynecology. 2006 Academic Article GET IT
Times cited: 12
ADAMTS13-binding IgG are present in patients with thrombotic thrombocytopenic purpura. Thrombosis and haemostasis. 2006 Academic Article GET IT
Times cited: 46
Annexin A5 levels in midtrimester amniotic fluid: association with intrauterine growth restriction. American journal of obstetrics and gynecology. 2006 Academic Article GET IT
Times cited: 7
Reduction of circulating annexin A5 levels and resistance to annexin A5 anticoagulant activity in women with recurrent spontaneous pregnancy losses. American journal of obstetrics and gynecology. 2006 Academic Article GET IT
Times cited: 53
Resistance to annexin A5 binding and anticoagulant activity in plasmas from patients with the antiphospholipid syndrome but not with syphilis. Journal of thrombosis and haemostasis : JTH. 2006 Article GET IT
Times cited: 11
Defective annexin A5 crystallization: a mechanism for pregnancy losses in the antiphospholipid syndrome. Thrombosis research. 2005 Conference Paper GET IT
Times cited: 10
Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome. Blood. 2004 Academic Article GET IT
Times cited: 86
Acquired von Willebrand syndrome 2004: International Registry--diagnosis and management from online to bedside. Hamostaseologie. 2004 Information Resource GET IT
Times cited: 42
Antibody-mediated interference with annexins in the antiphospholipid syndrome. Thrombosis research. 2004 Information Resource GET IT
Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assay. The American journal of pathology. 2003 Academic Article GET IT
Times cited: 146
Non-stroke neurological syndromes associated with antiphospholipid antibodies: evaluation of clinical and experimental studies. Lupus. 2003 Conference Paper GET IT
Times cited: 84
Platelet-endothelial interactions: sepsis, HIT, and antiphospholipid syndrome. Hematology. American Society of Hematology. Education Program. 2003 Information Resource GET IT
Times cited: 132
Molecular pathogenesis of the antiphospholipid syndrome. Circulation research. 2002 Information Resource GET IT
Times cited: 124
The antiphospholipid syndrome. Annual review of medicine. 2001 Information Resource GET IT
Times cited: 74
Seasonal distribution of antiphospholipid antibodies. Stroke. 2001 Academic Article GET IT
Times cited: 31
Thrombophilia: what's a practitioner to do?. Hematology. American Society of Hematology. Education Program. 2001 Information Resource GET IT
Times cited: 16
The pathogenic role of annexin-V in the antiphospholipid syndrome. Current rheumatology reports. 2000 Information Resource GET IT
Times cited: 17
Antiphosphatidyl serine antibodies are independently associated with ischemic stroke. Neurology. 1999 Academic Article GET IT
Times cited: 55
A possible solution to the paradox of the "lupus anticoagulant": antiphospholipid antibodies accelerate thrombin generation by inhibiting annexin-V. Thrombosis and haemostasis. 1999 Article GET IT
Times cited: 17
Elevated anticardiolipin antibody titer is a stroke risk factor in a multiethnic population independent of isotype or degree of positivity. Stroke. 1999 Academic Article GET IT
Times cited: 120
Thrombophilias: diagnosis and treatment of thrombophilia relating to contraception and pregnancy. Seminars in hematology. 1999 Information Resource GET IT
Times cited: 6
"Annexinopathies"--a new class of diseases. The New England journal of medicine. 1999 Editorial Article GET IT
Times cited: 59
Human atheromatous plaque extracts induce tissue factor activity (TFa) in monocytes and also express constitutive TFa. Thrombosis and haemostasis. 1999 Academic Article GET IT
Times cited: 18
Antiphospholipid antibodies accelerate plasma coagulation by inhibiting annexin-V binding to phospholipids: a "lupus procoagulant" phenomenon. Blood. 1998 Academic Article GET IT
Times cited: 160
In vitro studies of the interactions between platelets and amniotic membranes: a potential treatment for preterm premature rupture of the membranes. American journal of obstetrics and gynecology. 1998 Academic Article GET IT
Times cited: 27
Fibrillin containing elastic microfibrils support platelet adhesion under dynamic shear conditions. Thrombosis and haemostasis. 1998 Academic Article GET IT
Times cited: 16
Antiphospholipid antibodies, annexin V, and pregnancy loss. The New England journal of medicine. 1997 Article GET IT
Times cited: 8
Pregnancy loss in the antiphospholipid-antibody syndrome--a possible thrombogenic mechanism. The New England journal of medicine. 1997 Academic Article GET IT
Times cited: 449
Prothrombin activation fragment (F1.2) is increased in pregnant patients with antiphospholipid antibodies. Thrombosis research. 1997 Academic Article GET IT
Times cited: 18
Morphological relationships of von Willebrand factor, type VI collagen, and fibrillin in human vascular subendothelium. The American journal of pathology. 1996 Academic Article GET IT
Times cited: 25
Frequency of antibodies directed against heparin-platelet factor 4 in patients exposed to heparin through chronic hemodialysis. Thrombosis and haemostasis. 1996 Article GET IT
Times cited: 16
Reduced thrombogenicity of type VI collagen as compared to type I collagen. Thrombosis research. 1995 Academic Article GET IT
Times cited: 3
Platelet adhesion and aggregation on human type VI collagen surfaces under physiological flow conditions. Blood. 1995 Academic Article GET IT
Times cited: 69
Reduction of annexin-V (placental anticoagulant protein-I) on placental villi of women with antiphospholipid antibodies and recurrent spontaneous abortion. American journal of obstetrics and gynecology. 1994 Academic Article GET IT
Times cited: 204
The expression of the placental anticoagulant protein, annexin V, by villous trophoblasts: immunolocalization and in vitro regulation. Placenta. 1994 Academic Article GET IT
Times cited: 128
Abnormal coagulation profile in brain tumor patients during surgery. Neurosurgery. 1994 Academic Article GET IT
Times cited: 36
von Willebrand factor binding to collagen in patients with end-stage renal disease. The Journal of laboratory and clinical medicine. 1994 Academic Article GET IT
Times cited: 7
Co-localization of von Willebrand factor and type VI collagen in human vascular subendothelium. The American journal of pathology. 1993 Academic Article GET IT
Times cited: 42
Modest doses of nitroglycerin do not interfere with beef lung heparin anticoagulation in patients taking nitrates. Journal of cardiothoracic and vascular anesthesia. 1992 Academic Article GET IT
Times cited: 4
Reoperation, emergency and urgent open cardiac surgery in Jehovah's Witnesses. Chest. 1992 Academic Article GET IT
Times cited: 13
Alterations of platelet function induced by interleukin-2. Journal of immunotherapy : official journal of the Society for Biological Therapy. 1991 Academic Article GET IT
Times cited: 15
150-kD von Willebrand factor binding protein extracted from human vascular subendothelium is type VI collagen. The Journal of clinical investigation. 1991 Academic Article GET IT
Times cited: 95
Protein C and S levels in acute leukemia. American journal of hematology. 1991 Academic Article GET IT
Times cited: 24
Desmopressin acetate is a mild vasodilator that does not reduce blood loss in uncomplicated cardiac surgical procedures. Journal of cardiothoracic and vascular anesthesia. 1991 Academic Article GET IT
Times cited: 18
Preoperative evaluation of hematologic status. The Mount Sinai journal of medicine, New York. 1991 Information Resource GET IT
Times cited: 2
von Willebrand factor antigen is not an accurate marker of rat and guinea pig liver endothelial cells. Liver. 1990 Academic Article GET IT
Times cited: 25
Effects of endotoxin on iron uptake by the hepatocyte. The American journal of physiology. 1989 Academic Article GET IT
Times cited: 12
Thrombocythaemia and recurrent miscarriage. British journal of obstetrics and gynaecology. 1989 Academic Article GET IT
Times cited: 10
Functional behavior of vessels from pigs with von Willebrand disease. Values of platelet deposition are identical to those obtained on normal vessels. Arteriosclerosis (Dallas, Tex.). 1989 Academic Article GET IT
Times cited: 5
Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut. Proceedings of the National Academy of Sciences of the United States of America. 1988 Academic Article GET IT
Times cited: 161
In vitro multimerization of human von Willebrand factor from its subunits. British journal of haematology. 1987 Academic Article GET IT
Times cited: 2
Isolation and partial characterization of plasma membrane fatty acid binding proteins from myocardium and adipose tissue and their relationship to analogous proteins in liver and gut. Biochemical and biophysical research communications. 1987 Academic Article GET IT
Times cited: 39
Localization of surface vWF on resting and stimulated platelets. Blood. 1987 Academic Article GET IT
Times cited: 8
Platelet deposition on von Willebrand factor-deficient vessels. Extracorporeal perfusion studies in swine with von Willebrand's disease using native and heparinized blood. The Journal of laboratory and clinical medicine. 1987 Academic Article GET IT
Times cited: 34
Distribution of von Willebrand factor in porcine intima varies with blood vessel type and location. Arteriosclerosis (Dallas, Tex.). 1987 Academic Article GET IT
Times cited: 68
Isolation and properties of a capillary injury-related protease from lung lymph. Archives of biochemistry and biophysics. 1987 Academic Article GET IT
Times cited: 3
Indium-111 platelet kinetics in normal human subjects: tropolone versus oxine methods. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1986 Academic Article GET IT
Times cited: 14
Thrombocytopenia following peritonitis in surgical patients. A prospective study. Annals of surgery. 1986 Academic Article GET IT
Anticardiolipin antibodies in pregnant patients with systemic lupus erythematosus. The New England journal of medicine. 1986 Article GET IT
Times cited: 27
Subendothelial deposition of von Willebrand's factor requires the presence of endothelial cells. The Journal of laboratory and clinical medicine. 1982 Academic Article GET IT
Times cited: 39
Electron microscopic localization of factor-VIII-related antigen in adult human blood vessels. Blood. 1982 Academic Article GET IT
Times cited: 34
Plasma accumulation of metabolism of orally administered single dose L-5-hydroxytryptophan in man. Acta pharmacologica et toxicologica. 1981 Academic Article GET IT
Times cited: 16
The use of technetium-99m sulfur colloid as a marker for experimental venous thrombosis: concise communication. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1981 Academic Article GET IT
Times cited: 6
New category of vasopressin receptor in the central nervous system. Evidence that this receptor mediates the release of a humoral factor VIII-mobilizing principle. International journal of peptide and protein research. 1981 Academic Article GET IT
Times cited: 20
Localization of factor-VIII-related antigen in human vascular subendothelium. Blood. 1980 Academic Article GET IT
Times cited: 81
Bell's palsy and infectious mononucleosis. Lancet (London, England). 1973 Academic Article GET IT
Times cited: 51

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Background

education and training

M.D., Albert Einstein College of Medicine of Yeshiva University 73
B.A., Yeshiva University 1970

Contact

full name

Jacob H. Rand

primary email

jar9135@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Jacob H. Rand Professor of Pathology and Laboratory Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email

webpage