Zheng, Hongwu

Publications

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selected publications

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance. Nature communications. 2023 Academic Article GET IT
A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. The Journal of clinical investigation. 2022 Academic Article GET IT
Times cited: 6
DAXX-ATRX regulation of p53 chromatin binding and DNA damage response. Nature communications. 2022 Academic Article GET IT
Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma. Cancer discovery. 2021 Academic Article GET IT
Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification. Nature communications. 2021 Academic Article GET IT
Times cited: 20
Therapy-Induced Transdifferentiation Promotes Glioma Growth Independent of EGFR Signaling. Cancer research. 2021 Academic Article GET IT
A Combination of BRD4 and HDAC3 Inhibitors Synergistically Suppresses Glioma Stem Cell Growth by Blocking GLI1/IL6/STAT3 Signaling Axis. Molecular cancer therapeutics. 2020 Academic Article GET IT
Times cited: 2
RGFP966, a histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7. Biochemical pharmacology. 2020 Academic Article GET IT
Times cited: 2
CIC is a critical regulator of neuronal differentiation. JCI insight. 2020 Academic Article GET IT
Times cited: 19
Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα-mediated lipid metabolism. The Journal of clinical investigation. 2020 Academic Article GET IT
Times cited: 42
YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma. JCI insight. 2019 Academic Article GET IT
Times cited: 41
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway. International journal of oncology. 2019 Academic Article GET IT
Times cited: 60
ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization. The EMBO journal. 2019 Academic Article GET IT
Times cited: 57
Next-generation whole exome sequencing of glioblastoma with a primitive neuronal component. Brain tumor pathology. 2019 Academic Article GET IT
Times cited: 3
Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors. Stem cell reports. 2018 Academic Article GET IT
Times cited: 25
Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation. Cell reports. 2017 Academic Article GET IT
Times cited: 146
Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma. Cell reports. 2017 Academic Article GET IT
Times cited: 63
Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms. Cancer research. 2015 Academic Article GET IT
Times cited: 31
From the Cover: Neutralization of terminal differentiation in gliomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 63
ZNF365 promotes stability of fragile sites and telomeres. Cancer discovery. 2013 Academic Article GET IT
Times cited: 17
microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma. Cancer discovery. 2012 Academic Article GET IT
Times cited: 96
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 2012 Academic Article GET IT
Times cited: 1454
PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network. Cancer discovery. 2011 Academic Article GET IT
Times cited: 178
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature. 2011 Academic Article GET IT
Times cited: 417
FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer cell. 2010 Academic Article GET IT
Times cited: 126
PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer cell. 2010 Academic Article GET IT
Times cited: 212
Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 96
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell stem cell. 2009 Academic Article GET IT
Times cited: 378
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 128
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 2008 Academic Article GET IT
Times cited: 605
Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer cell. 2008 Academic Article GET IT
Times cited: 108
MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Molecular cell. 2005 Academic Article GET IT
Times cited: 193
DNA-binding and transactivation activities are essential for TAp63 protein degradation. Molecular and cellular biology. 2005 Academic Article GET IT
Times cited: 45
The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 64
The MDM2 RING finger is required for cell cycle-dependent regulation of its protein expression. FEBS letters. 2003 Academic Article GET IT
Times cited: 12
IGF-1 activates p21 to inhibit UV-induced cell death. Oncogene. 2003 Academic Article GET IT
Times cited: 26
Deregulation of Cdc2 kinase induces caspase-3 activation and apoptosis. Biochemical and biophysical research communications. 2003 Academic Article GET IT
Times cited: 11
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature. 2002 Academic Article GET IT
Times cited: 311
IGF-1 induces Pin1 expression in promoting cell cycle S-phase entry. Journal of cellular biochemistry. 2002 Academic Article GET IT
Times cited: 59

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Research

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Funding awarded

Identifying molecular vulnerabilities of ALT-dependent cancers awarded by National Cancer Institute Principal Investigator 2024 - 2029

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Background

education and training

M.S., Sichuan University (China) 96
Ph.D., Boston University School of Medicine 2003
B.S., Sichuan University (China) 1989

Contact

full name

Hongwu Zheng

primary email

hoz4001@med.cornell.edu

VIVO Weill Cornell Medical College

Hongwu Zheng Assistant Professor of Research in Pathology and Laboratory Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email