Heather Winona Stout-Delgado   Assistant Professor of Immunology in Medicine

Due to increased prevalence of comorbidities in older persons, impaired immune responses to vaccination, and the pervasiveness of antibiotic resistant bacterial strains, the goal of Dr. Stout-Delgado’s work is to understand the molecular mechanisms that underlie these impairments and develop cutting-edge therapies that specifically target and amplify innate immune responses in older persons. Through careful dissection of cellular and molecular signaling pathways, Dr. Stout-Delgado has made several key insights into mechanisms that contribute to increased susceptibility of older persons to infectious stimuli. Dr. Stout-Delgado’s current research interests include: (1) investigating the impact of aging on innate immune signaling responses to bacterial and viral pathogens, (2) examining mechanisms utilized by pathogenic stimuli to inhibit or circumvent innate immune responses in the lung, (3) designing and characterizing compounds and therapeutic strategies to improve morbidity and mortality in aging populations during primary or secondary pulmonary infections, and (4) understanding how molecular responses in fibrotic lung tissue contribute to altered innate immunity to bacterial and viral pathogens. Special focus for these studies will be on primary and secondary infection models using Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and influenza (H3N2 and H1N1 strains).  Dr. Stout-Delgado’s research is funded by R01 grants R01AG052530(NIH/NIA) and R01AG056699 (NIH/NIA).

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  • hes2019@med.cornell.edu