Grace C. H. Yang   Clinical Professor of Pathology and Laboratory Medicine

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THE APPLICATION OF ULTRAFAST PAPANICOLAOU STAIN IN CYTOLOGY I am interested in clinical reseach that directly effecting patient care. Back in 3/94, while as a junior faculty of this institution, I and a Cytopathology fellow shortened the Papanicolaou stain from 20 min. to 90 sec. as well as increasing the resolution of cellular details, thus named Ultrafast Papanicolaou stain (UFP). UFP allows cytopathologists to offer immediate diagnosis of FNA biopsies to the patients while they are waiting. Diagnostic clues enhanced by UFP include "grape-like" watery clear nuclei of follicular variant of papillary thyroid carcinoma; enhanced nuclear and cytoplasmic features to distinguish adenoid cystic carcinoma from look alike cylindromatous adenomas in salivary FNA; enhanced detection of Hodgkin cells in lymph node FNA; and the visualization of long microvilli of mesothelioma displayed within the retraction halos in pleural effusions. In additional to publication in peer-reviewed journals, The data that I collected in liver, pancreas, kidney, adrenal and retroperitoneum masses was summarized in a book that I co-wrote in 2007. The data collected for lung and mediastinum was summerized in book I co-edited in 2012. The data collected for thyroid along with ultrasound and histologic correlations was published by Cambridge University Press in April of 2013.


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  • Weill Cornell Medical College, Cornell University