Koretzky, Gary

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Communicating science effectively in times of crisis: time for reflection. Nature reviews. Immunology. 2023 Academic Article GET IT
The Cornell COVID-19 Testing Laboratory: A Model to High-Capacity Testing Hubs for Infectious Disease Emergency Response and Preparedness. Viruses. 2023 Academic Article GET IT
Building on the Past, Meeting the Moment. Journal of immunology (Baltimore, Md. : 1950). 2023 Academic Article GET IT
Pandemic Response Officers: Integration Between Medical, Public Health, and Higher Education Systems to Expedite Prevention and Response. Journal of public health management and practice : JPHMP. 2023 Academic Article GET IT
Integrated Surveillance System for Controlling COVID-19 on a University Campus, 2020‒2021. American journal of public health. 2022 Academic Article GET IT
Case-control study to identify risk factors for SARS-CoV-2 infection among university students in the northeastern USA. Transboundary and emerging diseases. 2022 Academic Article GET IT
Routine Surveillance and Vaccination on a University Campus During the Spread of the SARS-CoV-2 Omicron Variant. JAMA network open. 2022 Academic Article GET IT
Identifying Key Pathways and Components in Chemokine-Triggered T Lymphocyte Arrest Dynamics Using a Multi-Parametric Global Sensitivity Analysis. Cellular and molecular bioengineering. 2019 Academic Article GET IT
The Loss of TET2 Promotes CD8⁺ T Cell Memory Differentiation. Journal of immunology (Baltimore, Md. : 1950). 2017 Academic Article GET IT
Times cited: 110
Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era. Arthritis & rheumatology (Hoboken, N.J.). 2017 Information Resource GET IT
Times cited: 120
Reversible lacrimal gland-protective regulatory T-cell dysfunction underlies male-specific autoimmune dacryoadenitis in the non-obese diabetic mouse model of Sjögren syndrome. Immunology. 2015 Academic Article GET IT
Times cited: 31
Retraction: Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nature immunology. 2014 Article GET IT
Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation. PloS one. 2014 Academic Article GET IT
Times cited: 27
Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. Nature communications. 2014 Academic Article GET IT
Times cited: 32
Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse. Science signaling. 2014 Academic Article GET IT
Times cited: 57
Retraction. The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells. The Journal of experimental medicine. 2014 Article GET IT
Times cited: 1
Preview of Immunological Reviews for 2014. Immunological reviews. 2014 Editorial Article GET IT
The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. Science signaling. 2013 Academic Article GET IT
Times cited: 56
Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nature immunology. 2013 Academic Article GET IT
Times cited: 62
Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases. Cancer research. 2013 Academic Article GET IT
Times cited: 102
Diacylglycerol kinases: regulated controllers of T cell activation, function, and development. International journal of molecular sciences. 2013 Information Resource GET IT
Times cited: 36
Transient PKCα shuttling to the immunological synapse is governed by DGKζ and regulates L-selectin shedding. Journal of cell science. 2013 Academic Article GET IT
Times cited: 15
SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow. European journal of immunology. 2012 Academic Article GET IT
Times cited: 3
FoxO-dependent regulation of diacylglycerol kinase α gene expression. Molecular and cellular biology. 2012 Academic Article GET IT
Times cited: 31
Diacylglycerol kinase zeta negatively regulates CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow. Integrative biology : quantitative biosciences from nano to macro. 2012 Academic Article GET IT
Times cited: 6
PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation. Molecular and cellular biology. 2012 Academic Article GET IT
Times cited: 90
An integrated stochastic model of "inside-out" integrin activation and selective T-lymphocyte recruitment. Langmuir : the ACS journal of surfaces and colloids. 2012 Academic Article GET IT
Times cited: 8
Preview of immunological reviews for 2012. Immunological reviews. 2012 Editorial Article GET IT
Lymphocyte signaling: a Tuscan affair. Nature immunology. 2011 Conference Paper GET IT
The SLP-76 Src homology 2 domain is required for T cell development and activation. Journal of immunology (Baltimore, Md. : 1950). 2011 Academic Article GET IT
Times cited: 11
The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells. The Journal of experimental medicine. 2011 Academic Article GET IT
Times cited: 33
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells. The EMBO journal. 2011 Academic Article GET IT
Times cited: 23
Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. The Journal of clinical investigation. 2011 Academic Article GET IT
Times cited: 277
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity. 2011 Academic Article GET IT
Times cited: 144
Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells. Journal of immunology (Baltimore, Md. : 1950). 2011 Academic Article GET IT
Times cited: 52
Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 54
T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool. Blood. 2010 Academic Article GET IT
Times cited: 55
Multiple roles of CD4 and CD8 in T cell activation. Journal of immunology (Baltimore, Md. : 1950). 2010 Article GET IT
Times cited: 38
Dendritic cells induce regulatory T cell proliferation through antigen-dependent and -independent interactions. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 60
Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation. Molecular and cellular biology. 2010 Academic Article GET IT
Times cited: 15
Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010 Academic Article GET IT
Times cited: 363
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood. 2010 Academic Article GET IT
Times cited: 245
Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76. Cold Spring Harbor perspectives in biology. 2010 Information Resource GET IT
Times cited: 44
MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer cell. 2010 Academic Article GET IT
Times cited: 192
Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood. 2009 Academic Article GET IT
Times cited: 77
Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 124
Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production. Blood. 2009 Academic Article GET IT
Times cited: 9
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. The Journal of experimental medicine. 2009 Academic Article GET IT
Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation. Immunological reviews. 2009 Information Resource GET IT
Times cited: 17
Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis. The Journal of allergy and clinical immunology. 2009 Academic Article GET IT
Times cited: 14
Navigating the leukocyte signaling maze guided by Ariadne's thread. Nature immunology. 2009 Academic Article GET IT
The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells. Molecular and cellular biology. 2009 Academic Article GET IT
Times cited: 60
The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function. Immune network. 2009 Academic Article GET IT
Cutting edge: rescue of pre-TCR but not mature TCR signaling in mice expressing membrane-targeted SLP-76. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 4
Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 126
Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. The EMBO journal. 2009 Academic Article GET IT
Times cited: 54
Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. Molecular biology of the cell. 2009 Academic Article GET IT
Times cited: 67
T cell activation. Annual review of immunology. 2009 Information Resource GET IT
Times cited: 1497
Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 10
Differential requirement for the SAP-Fyn interaction during NK T cell development and function. Journal of immunology (Baltimore, Md. : 1950). 2008 Academic Article GET IT
Times cited: 47
Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo. The Journal of experimental medicine. 2008 Academic Article GET IT
Times cited: 31
Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. Immunity. 2008 Academic Article GET IT
Times cited: 81
Critical roles of the PI3K/Akt signaling pathway in T cell development. Immunology letters. 2008 Information Resource GET IT
Times cited: 109
Regulation of T cell integrin function by adapter proteins. Immunologic research. 2008 Information Resource GET IT
Times cited: 9
X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. Immunologic research. 2008 Information Resource GET IT
Times cited: 26
Indirect involvement of allergen-captured mast cells in antigen presentation. Blood. 2007 Academic Article GET IT
Times cited: 43
Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor protein. Journal of leukocyte biology. 2007 Academic Article GET IT
In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction. European journal of immunology. 2007 Academic Article GET IT
Times cited: 13
Phospholipase cbeta is critical for T cell chemotaxis. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 58
Antigen receptor signaling: the Tuscan connection. Nature immunology. 2007 Conference Paper GET IT
Compartmentalization of ITAM and integrin signaling by adapter molecules. Immunological reviews. 2007 Information Resource GET IT
Times cited: 38
The legacy of the Philadelphia chromosome. The Journal of clinical investigation. 2007 Information Resource GET IT
Times cited: 40
Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 113
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Molecular and cellular biology. 2007 Academic Article GET IT
Times cited: 95
Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 20
Proximal signaling events in Fc epsilon RI-mediated mast cell activation. The Journal of allergy and clinical immunology. 2007 Information Resource GET IT
Times cited: 84
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif. The EMBO journal. 2007 Academic Article GET IT
Times cited: 35
The role of diacylglycerol kinases in T cell anergy. Ernst Schering Foundation symposium proceedings. 2007 Information Resource GET IT
Times cited: 5
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. Nature immunology. 2006 Academic Article GET IT
Times cited: 211
Persistence of cooperatively stabilized signaling clusters drives T-cell activation. Molecular and cellular biology. 2006 Academic Article GET IT
Times cited: 105
The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. Molecular and cellular biology. 2006 Academic Article GET IT
Times cited: 102
PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization. Blood. 2006 Academic Article GET IT
Times cited: 34
ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists. Blood. 2006 Academic Article GET IT
Times cited: 54
The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation. Blood. 2006 Academic Article GET IT
Times cited: 87
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Molecular and cellular biology. 2006 Academic Article GET IT
Times cited: 63
Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Developmental cell. 2006 Academic Article GET IT
Times cited: 97
Adhesion- and degranulation-promoting adapter protein is required for efficient thymocyte development and selection. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 26
Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells. The Journal of experimental medicine. 2006 Academic Article GET IT
Times cited: 50
Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. Molecular and cellular biology. 2006 Academic Article GET IT
Functional hierarchy of the N-terminal tyrosines of SLP-76. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 47
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond. Nature reviews. Immunology. 2006 Information Resource GET IT
Times cited: 190
Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 39
Regulation of NKT cell development by SAP, the protein defective in XLP. Nature medicine. 2005 Academic Article GET IT
Times cited: 301
Antigen receptor signaling: the Tuscan chronicles. Nature immunology. 2005 Conference Paper GET IT
Times cited: 4
PRAM-1 is required for optimal integrin-dependent neutrophil function. Molecular and cellular biology. 2004 Academic Article GET IT
Times cited: 27
The SLP-76 family of adapter proteins. Seminars in immunology. 2004 Information Resource GET IT
Times cited: 59
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity. 2004 Academic Article GET IT
Times cited: 192
The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 195
Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice. The Journal of experimental medicine. 2004 Academic Article GET IT
Times cited: 27
Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 29
Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 61
Macrophage activation and Fcgamma receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors. Journal of leukocyte biology. 2003 Academic Article GET IT
Times cited: 15
Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements. Journal of immunology (Baltimore, Md. : 1950). 2003 Academic Article GET IT
SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils. Immunity. 2003 Academic Article GET IT
Times cited: 67
Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. Nature immunology. 2003 Academic Article GET IT
Times cited: 176
Azathioprine: old drug, new actions. The Journal of clinical investigation. 2003 Article GET IT
Times cited: 191
Adaptors as central mediators of signal transduction in immune cells. Nature immunology. 2003 Information Resource GET IT
Times cited: 213
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science (New York, N.Y.). 2003 Academic Article GET IT
Times cited: 360
Regulation of hematopoietic cell development and activation by adapter proteins. Immunologic research. 2003 Information Resource GET IT
Times cited: 7
Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 49
Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen. Blood. 2002 Academic Article GET IT
Times cited: 21
Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 90
Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. The Journal of experimental medicine. 2002 Academic Article GET IT
Times cited: 78
C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor gamma-chain-associated signaling pathway and by agglutination. Blood. 2001 Academic Article GET IT
Times cited: 38
Differential requirement for SLP-76 domains in T cell development and function. Immunity. 2001 Academic Article GET IT
Times cited: 85
Key molecules involved in receptor-mediated lymphocyte activation. Current protocols in immunology. 2001 Information Resource GET IT
Times cited: 6
Positive and negative regulation of T-cell activation by adaptor proteins. Nature reviews. Immunology. 2001 Information Resource GET IT
Times cited: 118
The future of the ASCI (American Society for Clinical Investigation) : a lesson from 2000 presidential election. The Journal of clinical investigation. 2001 Conference Paper GET IT
Times cited: 3
The role of the adapter molecule SLP-76 in platelet function. Oncogene. 2001 Information Resource GET IT
Times cited: 14
Coupling of the TCR to integrin activation by Slap-130/Fyb. Science (New York, N.Y.). 2001 Academic Article GET IT
Times cited: 258
Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells. The Journal of experimental medicine. 2001 Academic Article GET IT
Times cited: 150
PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 41
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength. Immunity. 2001 Academic Article GET IT
Times cited: 158
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 2001 Academic Article GET IT
Times cited: 426
The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 98
Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors. Proceedings of the National Academy of Sciences of the United States of America. 2000 Academic Article GET IT
Times cited: 73
Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling. The Journal of experimental medicine. 2000 Academic Article GET IT
Times cited: 104
Adapter proteins in lymphocyte antigen-receptor signaling. Current opinion in immunology. 2000 Information Resource GET IT
Times cited: 92
In vitro and in vivo macrophage function can occur independently of SLP-76. International immunology. 2000 Academic Article GET IT
Times cited: 15
The regulation of CD95 (Fas) ligand expression in primary T cells: induction of promoter activation in CD95LP-Luc transgenic mice. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 14
Functional association between SLAP-130 and SLP-76 in Jurkat T cells. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 55
Cutting edge: a novel function for the SLAP-130/FYB adapter protein in beta 1 integrin signaling and T lymphocyte migration. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 59
Antigen specific T lymphocyte activation. Reviews in immunogenetics. 2000 Information Resource GET IT
Times cited: 7
LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI. Molecular and cellular biology. 1999 Academic Article GET IT
Times cited: 162
The role of adapter proteins in T cell activation. Cellular and molecular life sciences : CMLS. 1999 Information Resource GET IT
Times cited: 21
Interaction of SLP adaptors with the SH2 domain of Tec family kinases. European journal of immunology. 1999 Academic Article GET IT
Times cited: 195
NK cytokine secretion and cytotoxicity occur independently of the SLP-76 adaptor protein. European journal of immunology. 1999 Academic Article GET IT
Times cited: 35
SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 65
Differential regulation of the IL-12 p40 promoter and of p40 secretion by CpG DNA and lipopolysaccharide. Journal of immunology (Baltimore, Md. : 1950). 1999 Academic Article GET IT
Times cited: 64
Human fetal retinal pigment epithelial cells induce apoptosis in the T-cell line Jurkat. Investigative ophthalmology & visual science. 1999 Academic Article GET IT
Times cited: 25
Adapter molecules in T cell receptor signaling. Inflammatory bowel diseases. 1999 Information Resource GET IT
Recent developments in lymphocyte activation: linking kinases to downstream signaling events. The Journal of clinical investigation. 1999 Information Resource GET IT
Times cited: 39
TNF-alpha increases ceramide without inducing apoptosis in alveolar type II epithelial cells. The American journal of physiology. 1999 Academic Article GET IT
Times cited: 33
Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 99
The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Current biology : CB. 1999 Academic Article GET IT
Times cited: 262
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice. The Journal of clinical investigation. 1999 Academic Article GET IT
Times cited: 160
Integration of T cell receptor-dependent signaling pathways by adapter proteins. Annual review of immunology. 1999 Information Resource GET IT
Times cited: 171
Signal transduction in T lymphocytes. Clinical and experimental rheumatology. 1999 Information Resource GET IT
Times cited: 22
Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine B lymphocytes. European journal of immunology. 1998 Academic Article GET IT
Times cited: 71
SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 101
SLP-76 expression is restricted to hemopoietic cells of monocyte, granulocyte, and T lymphocyte lineage and is regulated during T cell maturation and activation. Journal of immunology (Baltimore, Md. : 1950). 1998 Academic Article GET IT
Times cited: 67
Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 78
SLP-76-Cbl-Grb2-Shc interactions in FcgammaRI signaling. Blood. 1998 Academic Article GET IT
Times cited: 22
Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter. Molecular and cellular biology. 1998 Academic Article GET IT
Times cited: 181
Extracellular signal-regulated kinase-2, but not c-Jun NH2-terminal kinase, activation correlates with surface IgM-mediated apoptosis in the WEHI 231 B cell line. Journal of immunology (Baltimore, Md. : 1950). 1998 Academic Article GET IT
Times cited: 55
A newly identified response element in the CD95 ligand promoter contributes to optimal inducibility in activated T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 1998 Academic Article GET IT
Times cited: 30
Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science (New York, N.Y.). 1998 Academic Article GET IT
Times cited: 353
Molecular characterization of a CD95 signaling mutant. Arthritis and rheumatism. 1998 Academic Article GET IT
Times cited: 6
Insulin receptor-mediated dissociation of Grb2 from Sos involves phosphorylation of Sos by kinase(s) other than extracellular signal-regulated kinase. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 18
The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression. Journal of immunology (Baltimore, Md. : 1950). 1998 Academic Article GET IT
Times cited: 218
Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 196
Functional interactions between the thrombin receptor and the T-cell antigen receptor in human T-cell lines. Blood. 1997 Academic Article GET IT
Times cited: 19
T cell receptor-induced phosphorylation of Sos requires activity of CD45, Lck, and protein kinase C, but not ERK. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 19
Three domains of SLP-76 are required for its optimal function in a T cell line. Journal of immunology (Baltimore, Md. : 1950). 1997 Academic Article GET IT
Times cited: 66
The role of Grb2-associated proteins in T-cell activation. Immunology today. 1997 Information Resource GET IT
Times cited: 61
Signaling events in T lymphocytes leading to cellular activation or programmed cell death. Clinical immunology and immunopathology. 1997 Information Resource GET IT
Times cited: 26
Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events. Journal of immunology (Baltimore, Md. : 1950). 1997 Academic Article GET IT
Times cited: 149
Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 212
Identification of an oligodeoxynucleotide sequence motif that specifically inhibits phosphorylation by protein tyrosine kinases. Antisense & nucleic acid drug development. 1997 Academic Article GET IT
Times cited: 12
Sequestration of p56(lck) by gp120, a model for TCR desensitization. Journal of immunology (Baltimore, Md. : 1950). 1997 Academic Article GET IT
Times cited: 40
Surface expression of hemopoietic cell phosphatase fails to complement CD45 deficiency and inhibits TCR-mediated signal transduction in a Jurkat T cell clone. Journal of immunology (Baltimore, Md. : 1950). 1997 Academic Article GET IT
Times cited: 12
SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 65
Lovastatin inhibits T-cell antigen receptor signaling independent of its effects on ras. Blood. 1996 Academic Article GET IT
Times cited: 34
Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 86
CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells. Journal of immunology (Baltimore, Md. : 1950). 1996 Academic Article GET IT
Times cited: 88
Polymorphism in and localization of the gene LCP2 (SLP-76) to chromosome 5q33.1-qter. Genomics. 1996 Academic Article GET IT
Times cited: 4
Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cells. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 46
Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity. 1996 Academic Article GET IT
Times cited: 294
Epidermal growth factor receptor targeting prevents uncoupling of the Grb2-SOS complex. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 38
Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production. The Journal of experimental medicine. 1996 Academic Article GET IT
Times cited: 183
Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells. Blood. 1996 Academic Article GET IT
Times cited: 119
Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 29
Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 142
Adenoviral-mediated gene transfer to fetal pulmonary epithelia in vitro and in vivo. The Journal of clinical investigation. 1995 Academic Article GET IT
Times cited: 104
SH3 domain-mediated interaction of dystroglycan and Grb2. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 229
Regulation of CD45 engagement by the B-cell receptor CD22. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 84
CpG motifs in bacterial DNA trigger direct B-cell activation. Nature. 1995 Academic Article GET IT
Times cited: 2981
Regulation by CD45 of the tyrosine phosphorylation of high affinity IgE receptor beta- and gamma-chains. Journal of immunology (Baltimore, Md. : 1950). 1995 Academic Article GET IT
Times cited: 32
Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 293
LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 66
Surface expression of a heterologous phosphatase complements CD45 deficiency in a T cell clone. The Journal of experimental medicine. 1994 Academic Article GET IT
Times cited: 8
In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 66
Glycosyl phosphatidylinositol membrane anchor is not required for T cell activation through CD73. Journal of immunology (Baltimore, Md. : 1950). 1994 Academic Article GET IT
Times cited: 39
Restoration of CD2-mediated signaling by a chimeric membrane protein including the cytoplasmic sequence of CD45. Human immunology. 1994 Academic Article GET IT
Times cited: 5
The association between CD45 and lck does not require CD4 or CD8 and is independent of T cell receptor stimulation. Biochemical and biophysical research communications. 1994 Academic Article GET IT
CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 49
Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45. Science (New York, N.Y.). 1993 Academic Article GET IT
Times cited: 99
Growth inhibition of a B cell clone mediated by ligation of IL-4 receptors or membrane IgM. Journal of immunology (Baltimore, Md. : 1950). 1993 Academic Article GET IT
Times cited: 20
Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 261
Role of the CD45 tyrosine phosphatase in signal transduction in the immune system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1993 Information Resource GET IT
Times cited: 62
Restoration of T cell receptor-mediated signal transduction by transfection of CD45 cDNA into a CD45-deficient variant of the Jurkat T cell line. Journal of immunology (Baltimore, Md. : 1950). 1992 Academic Article GET IT
Times cited: 73
Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 352
Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 382
Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature. 1990 Academic Article GET IT
Times cited: 388
Heterogeneity of protein kinase C isoenzyme gene expression in human T cell lines. Protein kinase C-beta is not required for several T cell functions. Journal of immunology (Baltimore, Md. : 1950). 1989 Academic Article GET IT
Times cited: 31
The activation of T lymphocytes. Rheumatic diseases clinics of North America. 1987 Information Resource GET IT
Times cited: 3
Suppression of interleukin 2 receptor acquisition by monoclonal antibodies recognizing the 50 KD protein associated with the sheep erythrocyte receptor on human T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 1985 Academic Article GET IT
Times cited: 31
Interleukins and inhibitors in human lymphocyte regulation. Symposium on Fundamental Cancer Research. 1984 Academic Article GET IT
Spontaneous production of interleukin-1 by human alveolar macrophages. Clinical immunology and immunopathology. 1983 Academic Article GET IT
Times cited: 17
Evidence for an interleukin-independent pathway for human lymphocyte activation. Proceedings of the National Academy of Sciences of the United States of America. 1983 Academic Article GET IT
Times cited: 64
A phorbol ester (TPA) can replace macrophages in human lymphocyte cultures stimulated with a mitogen but not with an antigen. Journal of immunology (Baltimore, Md. : 1950). 1982 Academic Article GET IT
Times cited: 44

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Background

education and training

M.A., University of Pennsylvania 1999
M.D., University of Pennsylvania School of Medicine 1984
Ph.D., University of Pennsylvania School of Medicine 1984
A.B., Cornell University 1978

Contact

full name

Gary Koretzky

primary email

gak2008@med.cornell.edu

VIVO Weill Cornell Medical College

Gary Koretzky Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email