Barrat, Franck J.

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Neutrophil-plasmacytoid dendritic cell interaction leads to production of type I IFN in response to Mycobacterium tuberculosis. European journal of immunology. 2023 Academic Article GET IT
TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance. The Journal of experimental medicine. 2023 Academic Article GET IT
TLR8 escapes X chromosome inactivation in human monocytes and CD4⁺ T cells. Biology of sex differences. 2023 Academic Article GET IT
Dichotomous roles of RIPK3 in regulating the IFN response and NLRP3 inflammasome in human monocytes. Journal of leukocyte biology. 2023 Academic Article GET IT
Epigenetic memory of coronavirus infection in innate immune cells and their progenitors. Cell. 2023 Academic Article GET IT
Times cited: 2
Reclassification of plasmacytoid dendritic cells as innate lymphocytes is premature. Nature reviews. Immunology. 2023 Letter GET IT
Times cited: 3
Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19. Science immunology. 2022 Academic Article GET IT
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses. The Journal of experimental medicine. 2022 Academic Article GET IT
CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes. Nature communications. 2022 Academic Article GET IT
Times cited: 11
Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation. The Journal of experimental medicine. 2022 Academic Article GET IT
Tumor-derived Lysophosphatidic Acid Blunts Protective Type-I Interferon Responses in Ovarian Cancer. Cancer discovery. 2022 Academic Article GET IT
Noncytotoxic Inhibition of the Immunoproteasome Regulates Human Immune Cells In Vitro and Suppresses Cutaneous Inflammation in the Mouse. Journal of immunology (Baltimore, Md. : 1950). 2021 Academic Article GET IT
Structure-Activity Relationships of Noncovalent Immunoproteasome β5i-Selective Dipeptides. Journal of medicinal chemistry. 2020 Academic Article GET IT
Times cited: 10
Interferon target-gene expression and epigenomic signatures in health and disease. Nature immunology. 2019 Review GET IT
Times cited: 276
Role of type I interferons and innate immunity in systemic sclerosis: unbalanced activities on distinct cell types?. Current opinion in rheumatology. 2019 Information Resource GET IT
Times cited: 10
A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection. The Journal of experimental medicine. 2019 Information Resource GET IT
Times cited: 41
TLR8: No gain, no pain. The Journal of experimental medicine. 2018 Comment GET IT
Times cited: 11
Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8. Science translational medicine. 2018 Academic Article GET IT
Times cited: 81
Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 53
Musculoskeletal Involvement in SSc Is Associated with Worse Scores on Short Form-36 and Scleroderma Health Assessment Questionnaire and Lower Tumor Necrosis Factor-α Gene Expression in Peripheral Blood Mononuclear Cells. HSS journal : the musculoskeletal journal of Hospital for Special Surgery. 2016 Academic Article GET IT
Bruton's tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells. European journal of immunology. 2014 Academic Article GET IT
Times cited: 26
RNA recognition by human TLR8 can lead to autoimmune inflammation. The Journal of experimental medicine. 2013 Academic Article GET IT
Times cited: 139
Blocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection. PLoS pathogens. 2013 Academic Article GET IT
Times cited: 50
Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes. Nature medicine. 2012 Academic Article GET IT
Times cited: 278
Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?. Nature reviews. Immunology. 2011 Information Resource GET IT
Times cited: 110
A novel role of endothelin-1 in linking Toll-like receptor 7-mediated inflammation to fibrosis in congenital heart block. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 58
TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis. Gastroenterology. 2011 Academic Article GET IT
Times cited: 224
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Science translational medicine. 2011 Academic Article GET IT
Times cited: 1060
Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9. The Journal of experimental medicine. 2010 Academic Article GET IT
Times cited: 170
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature. 2010 Academic Article GET IT
Times cited: 302
Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 84
Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. The Journal of experimental medicine. 2009 Academic Article GET IT
Times cited: 581
Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: involvement of HMGB1 in anti-DNA antibody-induced renal injury. Immunology letters. 2008 Academic Article GET IT
Times cited: 69
Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Nature medicine. 2008 Academic Article GET IT
Times cited: 310
Development of TLR inhibitors for the treatment of autoimmune diseases. Immunological reviews. 2008 Information Resource GET IT
Times cited: 141
Strategies for use of IL-10 or its antagonists in human disease. Immunological reviews. 2008 Information Resource GET IT
Times cited: 296
PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. The Journal of experimental medicine. 2008 Academic Article GET IT
Times cited: 195
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. European journal of immunology. 2007 Academic Article GET IT
Times cited: 229
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 348
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nature medicine. 2007 Academic Article GET IT
Times cited: 2022
Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis. Blood. 2007 Academic Article GET IT
Times cited: 232
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nature medicine. 2007 Information Resource GET IT
Times cited: 676
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. The Journal of experimental medicine. 2006 Academic Article GET IT
Times cited: 321
Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. The Journal of clinical investigation. 2005 Academic Article GET IT
Times cited: 504
Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity. 2005 Academic Article GET IT
Times cited: 237
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 790
Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 106
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 529
IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences. Blood. 2003 Academic Article GET IT
Times cited: 119
In vitro generation of IL-10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by Th1- and Th2-inducing cytokines. Immunology letters. 2003 Information Resource GET IT
Times cited: 38
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. The Journal of experimental medicine. 2002 Academic Article GET IT
Times cited: 1006
1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. Journal of immunology (Baltimore, Md. : 1950). 2001 Academic Article GET IT
Times cited: 815
A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production. The Journal of experimental medicine. 2001 Academic Article GET IT
Times cited: 126
Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. The Journal of experimental medicine. 2001 Academic Article GET IT
Times cited: 206
Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 44
Protein truncation test of LYST reveals heterogenous mutations in patients with Chediak-Higashi syndrome. Blood. 2000 Academic Article GET IT
Times cited: 90
Genetic basis of hemophagocytic lymphohistiocytosis syndrome (Review). International journal of molecular medicine. 1999 Information Resource GET IT
Times cited: 58
Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 66
[Genetic defects in control of T cell activation evolving in a syndrome of lymphohistiocytic activation]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 1999 Academic Article GET IT
Times cited: 3
Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene. Nature genetics. 1997 Academic Article GET IT
Times cited: 345
Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse. Human molecular genetics. 1997 Academic Article GET IT
Times cited: 86
Localization of the Rab escort protein-2 (REP2) and inositol 1,4,5-trisphosphate 3-kinase (ITPKB) genes to mouse chromosome 1 by in situ hybridization and precision of the syntenic regions between mouse and human 1q42-q44. Genomics. 1997 Academic Article GET IT
Times cited: 4
Genetic and physical mapping of the Chediak-Higashi syndrome on chromosome 1q42-43. American journal of human genetics. 1996 Academic Article GET IT
Times cited: 85

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Background

education and training

Ph.D., University of Paris (France) 1998
M.S., University of Paris (France) 1995
B.S., University of Nice (France) 1993

Contact

full name

Franck J. Barrat

primary email

frb3002@med.cornell.edu

VIVO Weill Cornell Medical College

Franck J. Barrat Professor of Microbiology and Immunology

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email