1. Development of diabetic nephropathy in children: We are evaluating the efficiency of early treatment with angiotensin converting enzyme inhibitors in preventing the progression of kidney disease in children with type I insulin dependent diabetes mellitus. We are also evaluating plasma prorenin activity as a predictor of patients at high risk of developing diabetic nephropathy.
2. Renal function in cyanotic heart disease: The objectives of this study are to quantitate the prevalence of renal dysfunction in patients with cyanotic congenital heart disease.
3. Treatment of steroid-resistant nephrotic syndrome: We are investigating the effect of intravenous methylprednisolone pulse therapy on patients with steroid-resistant nephrotic syndrome secondary to focal segmental glomerulosclerosis and mesangial proliferative glomerulonephritis.
4. Renal functional reserve and microalbuminuria in normotensive offspring of hypertensive parents: The normotensive offspring of hypertensive parents may represent a "prehypertensive stage," where abnormalities may be found as preceding the development of hypertension. The purpose of this study is to identify subtle alterations in renal function in such persons.
5. Intravenous immunoglobulin infusions in the treatment of patients with membranoproliferative glomerulonephritis: Patients with this diagnosis and high C3 nephritic factor levels have been receiving intravenous immunoglobulin in an attempt to control the activity of their diseases. We are investigating the effect of these infusions on urinary protein excretion, renal function and serum complement levels.