David N Posnett   Professor Emeritus of Medicine

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Human Molecular Immunobiology

My interests have focused for 35 years on how the immune system recognizes foreign antigens and microbes. The receptors and some of the ligands, in particular superantigens, were studied in detail. As a trained physician I have always tended to use human diseases as different models for understanding the way the immune system works. Examples are autoimmunity (rheumatoid arthritis), infectious diseases (HIV, Herpes infections and Toxic Shock Syndrome), immune recognition and rejection of cancer cells (mouse model of melanoma) and immunodeficiency (in old age or after stem cell transplantation in cancer patients). A more recent interest is whole genome sequencing of certain cancers to understand their biology.


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Primary Email

  • dposnett@med.cornell.edu