David J. Christini   Professor of Biomedical Engineering in Medicine

Sudden cardiac death, primarily caused by ventricular arrhythmias, is a major public health problem – it is one of the leading causes of mortality, resulting in more than 350,000 annual deaths in the United States alone. Our group’s efforts are focused on improving our understanding of, and therapies for, cardiac arrhythmias. We primarily investigate biophysical mechanisms of electrophysiological instabilities and arrhythmia onset, from the subcellular to organ level. Because of the complexity of electrophysiological dynamics (both temporal and spatiotemporal), we use a multiscale approach that bridges the gap between physics and biology.  Our experiments employ electrophysiological and imaging modalities, primarily at the cellular and tissue levels. We combine our experimental data with clinical data to inform computational cardiac modeling that scales up from the single cell to the whole organ. Such a combination of experimental, computational, and clinical approaches provides the necessary synergy to impact our understanding of cardiac arrhythmias.

For more information, including descriptions of ongoing projects, please visit christinilab.org .


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