David J. Christini   Professor of Biomedical Engineering in Medicine

Sudden cardiac death, primarily caused by ventricular arrhythmias, is a major public health problem – it is one of the leading causes of mortality, resulting in more than 350,000 annual deaths in the United States alone. Our group’s efforts are focused on improving our understanding of, and therapies for, cardiac arrhythmias. We primarily investigate biophysical mechanisms of electrophysiological instabilities and arrhythmia onset, from the subcellular to organ level. Because of the complexity of electrophysiological dynamics (both temporal and spatiotemporal), we use a multiscale approach that bridges the gap between physics and biology.  Our experiments employ electrophysiological and imaging modalities, primarily at the cellular and tissue levels. We combine our experimental data with clinical data to inform computational cardiac modeling that scales up from the single cell to the whole organ. Such a combination of experimental, computational, and clinical approaches provides the necessary synergy to impact our understanding of cardiac arrhythmias.

For more information, including descriptions of ongoing projects, please visit christinilab.org .

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Funding awarded

  • Weill Cornell Initiative for Maximizing Student Development  awarded by National Institute of General Medical Sciences Principal Investigator 2019 - 2024
  • Deriving Functional Cardiac Pacemaker Cells from Human Embryonic Stem Cells  awarded by New York State Stem Cell Science (NYSTEM) Co-Investigator 2018 - 2021
  • A Gata456 Pipeline of Discovery  awarded by National Heart, Lung, & Blood Institute Key Personnel 2017 - 2023
  • Regulation of Cardiogenesis by GATA Transcription Factors  awarded by United States Department of Defense Key Personnel 2017 - 2020
  • Coalition for Next Generation Life Sciences Doctoral Alumni and Postdoctoral Career Outcomes  awarded by United States Department of Transportation Principal Investigator Subaward 2017 - 2019
  • Multiscale Modeling to Map Cardiac Electrophysiology Between Species  awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2017 -

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