selected publications
- Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch. 2024 GET IT
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H3K36 dimethylation shapes the epigenetic interaction landscape by directing repressive chromatin modifications in embryonic stem cells.
Genome research.
2022
Academic Article
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Times cited: 13 -
Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands.
Nature genetics.
2021
Academic Article
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Times cited: 50 -
Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.
Proceedings of the National Academy of Sciences of the United States of America.
2021
Academic Article
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Times cited: 25 -
Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.
Proceedings of the National Academy of Sciences of the United States of America.
2020
Academic Article
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Times cited: 51 -
PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor.
Proceedings of the National Academy of Sciences of the United States of America.
2019
Academic Article
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Times cited: 28 -
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape.
Nature.
2019
Academic Article
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Times cited: 284 -
Oncogenic Mechanisms of Histone H3 Mutations.
Cold Spring Harbor perspectives in medicine.
2017
Review
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Times cited: 45 -
Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells.
The Journal of clinical investigation.
2015
Academic Article
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Times cited: 54 -
Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation.
The Journal of clinical investigation.
2013
Academic Article
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Times cited: 14