Clement, Cristina

Publications

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selected publications

Mitomycin C and Its Analog Trigger Cytotoxicity in MCF-7 and K562 cancer cells through the regulation of RAS and MAPK/ERK pathways. Chemico-biological interactions. 2024 Academic Article GET IT
Non-mutational neoantigens in disease. Nature immunology. 2024 Review GET IT
Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy. Cell reports. 2023 Academic Article GET IT
Senolytic treatment reduces oxidative protein stress in an aging male murine model of post-traumatic osteoarthritis. Aging cell. 2023 Academic Article GET IT
PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes. Science immunology. 2022 Academic Article GET IT
Summary of the 2021 ICRP workshop on the future of radiological protection. Journal of radiological protection : official journal of the Society for Radiological Protection. 2022 Academic Article GET IT
Times cited: 6
Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice. Scientific reports. 2022 Academic Article GET IT
Cytotoxicity, crosslinking and biological activity of three mitomycins. Bioorganic chemistry. 2022 Academic Article GET IT
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine. Nature communications. 2021 Academic Article GET IT
A protocol for qualitative and quantitative measurement of endosomal processing using hot spot analysis. STAR protocols. 2021 Academic Article GET IT
Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection. Nature communications. 2021 Academic Article GET IT
Distinguishing Signal From Noise in Immunopeptidome Studies of Limiting-Abundance Biological Samples: Peptides Presented by I-A^b in C57BL/6 Mouse Thymus. Frontiers in immunology. 2021 Academic Article GET IT
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 Academic Article GET IT
Times cited: 141
Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery. Immunity. 2021 Academic Article GET IT
Times cited: 27
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control. The Journal of clinical investigation. 2021 Academic Article GET IT
Times cited: 112
In vivo data: treatment with the F11R/JAM-A peptide 4D decreases mortality and reduces the generation of atherosclerotic plaques in ApoE-deficient mice. Data in brief. 2020 Academic Article GET IT
Times cited: 4
Lymphatic remodelling in response to lymphatic injury in the hind limbs of sheep. Nature biomedical engineering. 2019 Academic Article GET IT
Times cited: 7
Lymphatic Cannulation for Lymph Sampling and Molecular Delivery. Journal of immunology (Baltimore, Md. : 1950). 2019 Academic Article GET IT
Times cited: 16
The negative effect of lipid challenge on autophagy inhibits T cell responses. Autophagy. 2019 Academic Article GET IT
Times cited: 19
Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients. The Journal of experimental medicine. 2019 Academic Article GET IT
Times cited: 91
Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers. JCI insight. 2019 Academic Article GET IT
Times cited: 104
A peptide antagonist of F11R/JAM-A reduces plaque formation and prolongs survival in an animal model of atherosclerosis. Atherosclerosis. 2019 Academic Article GET IT
Times cited: 11
Sequence-Dependent Diastereospecific and Diastereodivergent Crosslinking of DNA by Decarbamoylmitomycin C. Chemistry (Weinheim an der Bergstrasse, Germany). 2019 Academic Article GET IT
Times cited: 7
In vitro model reveals a role for mechanical stretch in the remodeling response of lymphatic muscle cells. Microcirculation (New York, N.Y. : 1994). 2018 Academic Article GET IT
Times cited: 5
Involvement of Akt in mitomycin C and its analog triggered cytotoxicity in MCF-7 and K562 cancer cells. Chemical biology & drug design. 2018 Academic Article GET IT
Times cited: 5
Quantitative Profiling of the Lymph Node Clearance Capacity. Scientific reports. 2018 Academic Article GET IT
Times cited: 30
Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 45
Autoimmune response to transthyretin in juvenile idiopathic arthritis. JCI insight. 2016 Academic Article GET IT
Role of Carbonyl Modifications on Aging-Associated Protein Aggregation. Scientific reports. 2016 Academic Article GET IT
Times cited: 83
Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance. Aging cell. 2015 Academic Article GET IT
Times cited: 97
Annexin A2 promotes phagophore assembly by enhancing Atg16L⁺ vesicle biogenesis and homotypic fusion. Nature communications. 2015 Academic Article GET IT
Times cited: 35
Hydrodynamic size-based separation and characterization of protein aggregates from total cell lysates. Nature protocols. 2014 Academic Article GET IT
Times cited: 6
Molecular analysis of chromium and cobalt-related toxicity. Scientific reports. 2014 Academic Article GET IT
Times cited: 158
Development of new antiatherosclerotic and antithrombotic drugs utilizing F11 receptor (F11R/JAM-A) peptides. Biopolymers. 2014 Academic Article GET IT
Times cited: 4
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. Journal of medicinal chemistry. 2014 Academic Article GET IT
Times cited: 50
Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70. Journal of medicinal chemistry. 2014 Academic Article GET IT
Times cited: 48
Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification. Chemistry & biology. 2013 Academic Article GET IT
Times cited: 45
Protein expression profiles of human lymph and plasma mapped by 2D-DIGE and 1D SDS-PAGE coupled with nanoLC-ESI-MS/MS bottom-up proteomics. Journal of proteomics. 2012 Academic Article GET IT
Times cited: 59
Age-related oxidative stress compromises endosomal proteostasis. Cell reports. 2012 Academic Article GET IT
Times cited: 76
Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris. Nature communications. 2012 Academic Article GET IT
Times cited: 43
Rational design and characterization of D-Phe-Pro-D-Arg-derived direct thrombin inhibitors. PloS one. 2012 Academic Article GET IT
Times cited: 23
Oxidative stress, inflamm-aging and immunosenescence. Journal of proteomics. 2011 Information Resource GET IT
Times cited: 196
Microautophagy of cytosolic proteins by late endosomes. Developmental cell. 2011 Academic Article GET IT
Times cited: 662
Crystallization and preliminary crystallographic characterization of three peptidic inhibitors in complex with α-thrombin. Acta crystallographica. Section F, Structural biology and crystallization communications. 2010 Academic Article GET IT
Times cited: 4
Design of a flexible cell-based assay for the evaluation of heat shock protein 70 expression modulators. Assay and drug development technologies. 2010 Academic Article GET IT
Times cited: 3
The lymph as a pool of self-antigens. Trends in immunology. 2010 Article GET IT
Times cited: 58
An expanded self-antigen peptidome is carried by the human lymph as compared to the plasma. PloS one. 2010 Academic Article GET IT
Times cited: 55
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 275
Isothermal titration calorimetry and inhibition of platelets aggregation by [D-Phe/(transcinnamoyl)-Pro-D-Arg-P1'-CONH2] peptides inhibitors of thrombin. Advances in experimental medicine and biology. 2009 Academic Article GET IT
Times cited: 4
Synthesis of an oligodeoxyribonucleotide adduct of mitomycin C by the postoligomerization method via a triamino mitosene. Journal of the American Chemical Society. 2008 Academic Article GET IT
Times cited: 16
Immunogenecity of modified alkane polymers is mediated through TLR1/2 activation. PloS one. 2008 Academic Article GET IT
Times cited: 45
The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding. FEBS letters. 2008 Academic Article GET IT
Times cited: 49
Design of a fluorescence polarization assay platform for the study of human Hsp70. Bioorganic & medicinal chemistry letters. 2008 Academic Article GET IT
Times cited: 20
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nature chemical biology. 2007 Academic Article GET IT
Times cited: 142
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer cell. 2006 Academic Article GET IT
Times cited: 430
Synthesis of a red-shifted fluorescence polarization probe for Hsp90. Bioorganic & medicinal chemistry letters. 2006 Academic Article GET IT
Times cited: 25
DNA adduct of the mitomycin C metabolite 2,7-diaminomitosene is a nontoxic and nonmutagenic DNA lesion in vitro and in vivo. Chemical research in toxicology. 2005 Academic Article GET IT
Times cited: 15
Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity. Biochemistry. 2001 Academic Article GET IT
Times cited: 21

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Background

education and training

B.S., M.S., University of Bucharest (Romania) 91
Ph.D., City University of New York 2006
M.S., University of Missouri 1998

Contact

full name

Cristina Clement

primary email

ccc4002@med.cornell.edu

VIVO Weill Cornell Medical College

Cristina Clement Associate Professor of Radiation Biology Research in Radiation Oncology (Pending Appointment at Rank)

Publications

selected publications

Background

education and training

Contact

full name

primary email