Depression is a major psychiatric disorder in the elderly that has comorbidity with dementia and sensory deficits (hearing and visual deficits). Electrophysiologic measures including evoked potentials are being used in this investigation to identify subgroups of depressed and depressed-demented patients with electrophysiologic abnormalities and sensory deficits, and examine its relationship to:
Recovery from depression.
The propensity for recurrences and the development of cognitive dysfunction/dementia.
Medical morbidity, including its association with treatment resistance and relapse.
On-going projects in our laboratory include:
The identification of lesion-sites in end organs as well as the auditory and visual pathways in brains of depressed and depressed-demented patients.
Examining effects of correction of sensory deficits on mood, memory, and quality of life.
Examining effects of memory enhancing drugs on electrophysiologic measures.