selected publications
- Multiscale protein networks systematically identify aberrant protein interactions and oncogenic regulators in seven cancer types. Journal of hematology & oncology. 2023 Letter GET IT
- Epinephrine inhibits PI3Kα via the Hippo kinases. Cell reports. 2023 Academic Article GET IT
- Author Correction: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma. 2023 GET IT
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Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.
Science translational medicine.
2023
Academic Article
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Times cited: 1 - An atlas of substrate specificities for the human serine/threonine kinome. Nature. 2023 Academic Article GET IT
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A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma.
Nature communications.
2022
Academic Article
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Times cited: 9 -
PI3K drives the de novo synthesis of coenzyme A from vitamin B5.
Nature.
2022
Academic Article
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Times cited: 29 - PI3King the Environment for Growth: PI3K Activation Drives Transcriptome Changes That Support Oncogenic Growth. Cancer research. 2022 Editorial Article GET IT
- Circling back to PTEN: Fumarate inhibits canonical tumor suppressor. Molecular cell. 2022 Comment GET IT
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A Functional Precision Oncology Approach to Identify Treatment Strategies for Myxofibrosarcoma Patients.
2021
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Times cited: 4 -
Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential.
Proceedings of the National Academy of Sciences of the United States of America.
2021
Academic Article
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Times cited: 11 -
Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer.
Nature reviews. Endocrinology.
2020
Information Resource
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Times cited: 149 -
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.
Cell reports.
2019
Academic Article
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Times cited: 24 -
Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer.
Cancers.
2019
Academic Article
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Times cited: 42 -
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.
Nature.
2018
Academic Article
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Times cited: 412 -
Cancer metabolism gets physical.
Science translational medicine.
2018
Review
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Times cited: 32 -
Fenofibrate prevents skeletal muscle loss in mice with lung cancer.
Proceedings of the National Academy of Sciences of the United States of America.
2018
Academic Article
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Times cited: 76 -
Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity.
Immunity.
2017
Academic Article
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Times cited: 41 -
The PI3K Pathway in Human Disease.
Cell.
2017
Review
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Times cited: 1577 -
Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine.
Cancer discovery.
2017
Academic Article
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Times cited: 673 -
Obesity and Cancer Mechanisms: Cancer Metabolism.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2016
Information Resource
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Times cited: 226 -
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.
Science signaling.
2015
Academic Article
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Times cited: 45 -
Analysis of intracellular PTEN signaling and secretion.
Methods (San Diego, Calif.).
2014
Review
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Times cited: 11 -
Metformin and erlotinib synergize to inhibit basal breast cancer.
Oncotarget.
2014
Academic Article
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Times cited: 44 -
Molecular pathways: intercellular PTEN and the potential of PTEN restoration therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2014
Review
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Times cited: 38 -
A unified nomenclature and amino acid numbering for human PTEN.
Science signaling.
2014
Academic Article
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Times cited: 50 -
PTEN function: the long and the short of it.
Trends in biochemical sciences.
2014
Review
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Times cited: 222 -
Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Academic Article
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Times cited: 48 -
A secreted PTEN phosphatase that enters cells to alter signaling and survival.
Science (New York, N.Y.).
2013
Academic Article
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Times cited: 246 -
Survival factor NFIL3 restricts FOXO-induced gene expression in cancer.
Genes & development.
2013
Academic Article
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Times cited: 39 -
Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells.
Cancer biology & therapy.
2013
Academic Article
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Times cited: 31 -
RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription.
Nature communications.
2013
Academic Article
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Times cited: 46 -
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.
Science (New York, N.Y.).
2009
Academic Article
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Times cited: 191 -
3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.
Cancer research.
2009
Academic Article
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Times cited: 119 -
Gab2-mediated signaling promotes melanoma metastasis.
The American journal of pathology.
2009
Academic Article
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Times cited: 66 -
Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina.
American journal of physiology. Heart and circulatory physiology.
2009
Academic Article
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Times cited: 48 -
Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability.
Cancer research.
2008
Academic Article
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Times cited: 95 -
Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro.
Blood.
2006
Academic Article
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Times cited: 135