Attilio Orazi   Professor of Pathology and Laboratory Medicine

The research program in the Division of Hematopathology is mostly focused on identifying distinctive immunologic and molecular genetic characteristics of the hematologic neoplasms that are useful in their diagnosis, classification, and prognosis, and elucidating the mechanisms that are involved in their pathogenesis. On-going projects are mostly in the following areas: (1) The investigation of genetic alterations that are associated with various clinicopathologic subtypes of malignant lymphomas and their subsequent evaluation as potential diagnostic and prognostic indicators. (2) The investigation of the molecular genetic events that underlie and are responsible for the clinical progression and morphologic transformation from low grade malignancies to clinically aggressive diseases. (3) The identification of the molecular genetic events responsible for the development of lymphoproliferative disorders in organ transplant recipients and their progression from oligoclonal proliferations responsive to diminished immunosuppression to autonomous monoclonal proliferations unresponsive to therapy. (4) To elucidate molecular genetic events involved in the pathogenesis of myelodysplastic, myeloproliferative, and other types of myeloid neoplasms, and their correlation with pathologic characteristics and clinical manifestations, in an attempts at clarifying controversial issues relevant to disease classification and clinical management of these patients.


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Grants awarded

  • MPD Research Consortium  awarded by National Cancer Institute Principal Investigator Subaward 2012 - 2015



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