Anjali M. Rajadhyaksha   Associate Professor of Neuroscience in Pediatrics

Associate Professor of Neurology in Pediatrics, Associate Professor of Neuroscience

Dr. Rajadhyaksha's current work is focused on examining neuronal voltage-gated L-type Ca2 channel subunits, Cav1.2 and Cav1.3 in experience-dependent plasticity. She is currently pursuing the following projects in her laboratory.1. Use of genetic mutant mouse models to delineate the roles of the voltage-gated L-type Ca2 channel subunits, Cav1.2 and Cav1.3 in psychostimulant-induced addictive behaviors and to explore the molecular mechanisms by which Cav1.2 and Cav1.3 channels mediate persistent adaptations in dopamine and glutamate neurotransmission in the rodent brain.2. Use of RNA interference (RNAi) to generate spatial and temporal knockdown of Cav1.2 and Cav1.3 to examine the molecular mechanisms of learning and memory.3. To identify mechanisms of dysregulation of Ca2 signaling in Autism spectrum disorder, a brain developmental disorder.

Publications

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Selected publications

Research

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Select federal grants awarded

  • RNAi Knockdown of CAv1.3 in the VTA and Addiction  awarded by National Institute on Drug Abuse Principal Investigator 2008 - 2010
  • The Role of Cav1.2 L-Type Ca2+ Channels in Cocaine-Induced Reinstatement  awarded by National Institute on Drug Abuse Principal Investigator 2012 -
  • EnygmaGym  awarded by United States Department of Defense Key Personnel 2011 - 2014
  • Exome Re-Sequencing Candidate Loci for Familial Essential Tremor  awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2011 - 2013
  • Structural MR Analyses of Drug Exposed Brains  awarded by National Institute on Drug Abuse Key Personnel 2005 - 2010
  • Cav 1.3 L-Type Calcium Channel Mechanisms in Cocaine Seeking  awarded by National Institute on Drug Abuse Principal Investigator Subaward 2014 -

Background

Contact

full name

  • Dr. Anjali M Rajadhyaksha

primary email

  • amr2011@med.cornell.edu

Other

Primary Affiliation

  • Weill Cornell Medical College, Cornell University